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Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. Additionally we are shipping ICK Antibodies (77) and ICK Proteins (11) and many more products for this protein.
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These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis
findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress.
the expressions of ICK/MAK (show MAK ELISA Kits)/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
In glioblastoma cells with deregulated high levels of CCRK (show CDK20 ELISA Kits), its depletion restores cilia through ICK and an ICK-related kinase MAK (show MAK ELISA Kits), thereby inhibiting glioblastoma cell proliferation.
High ICK expression is associated with prostate cancer.
an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor (show RPTOR ELISA Kits) Thr (show TRH ELISA Kits)-908.
ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity
ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1 (show CCND1 ELISA Kits), c-Myc (show MYC ELISA Kits) and p21Cip1 (show CDKN1A ELISA Kits).
ICK and FBX9 (show FBXO9 ELISA Kits) are divergently transcribed from a bidirectional promoter that is GC-rich (show RELB ELISA Kits) and contains a CpG island.
PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase (show CDK20 ELISA Kits)) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe (show BAT3 ELISA Kits), an essential regulator of proliferation and apoptosis during mammalian development.
Data indicate an essential role for intestinal cell kinase (ICK) in lung development and advances the mechanistic understanding of endocrine-cerebro-osteodysplasia (ECO) syndrome.
The results of this study found that loss of Ick leads to abnormal localization of the IFT component in kinocilia, PCP (show BMP1 ELISA Kits) defects in HCs (show HLCS ELISA Kits), and hearing dysfunction.
Data indicate that ciliary defects caused by a lack of functional intestinal cell kinase (ICK) leads to abnormal Sonic hedgehog (Shh (show SHH ELISA Kits)) signaling, resulting in congenital disorders such as endocrine-cerebro-osteodysplasia (ECO) syndrome .
ICK is a Kif3a (show KIF3A ELISA Kits) kinase and essential for proper ciliogenesis in development by regulating ciliary transport at the tip of cilia.
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
intestinal cell (MAK-like) kinase
, intestinal cell kinase
, serine/threonine-protein kinase ICK-like
, MAK-related kinase
, laryngeal cancer kinase 2
, serine/threonine protein kinase
, serine/threonine-protein kinase ICK
, heart serine-threonine protein kinase