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INVS encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. Additionally we are shipping Inversin Antibodies (7) and Inversin Proteins (5) and many more products for this protein.
Showing 4 out of 6 products:
Human Inversin ELISA Kit for Sandwich ELISA - ABIN416963
Costa, Eberlin, Polettini, da Costa Pereira, Pereira, Ferreira, Dolis, Torloni: Neuromodulatory and anti-inflammatory ingredient for sensitive skin: in vitro assessment. in Inflammation & allergy drug targets 2014
Inversin relays Frizzled-8 (show FZD8 ELISA Kits) signals to promote proximal pronephros development.
The present study indicates that calmodulin binding sites (IQ motifs) are crucial in controlling the biological activity of both mouse and Xenopus inv proteins
Collectively, these results indicated that inversin might promote the tumorigenicity of lung cancer cells and serve as a novel therapeutic target of non-small cell lung cancer.
Akt (show AKT1 ELISA Kits) phosphorylates inversin at amino acids 864-866 that are required not only for Akt (show AKT1 ELISA Kits) interaction, but also for inversin dimerization.
Truncating mutations in NPHP2 gene is associated with nephronophthisis-related ciliopathy.
ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8 (show NEK9 ELISA Kits), INVS and NPHP3 (show NPHP3 ELISA Kits).
INVS mutation can cause juvenile nephronophthisis with abnormal reactivity of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway.
has conserved ankyrin repeat and IQ domains and interacts with calmodulin (show CALM1 ELISA Kits)
analysis of a homozygous mutation in exon 13 of inversin (INVS) (C2719T, R907X) in a patient with retinitis pigmentosa and renal failure [case report]
Thus, although considered a common variant, inv(10)(p11.2q21.2) has a single ancestral founder among northern Europeans.
Cystic kidney disease has been linked to mutations in the Invs gene in mice with an inversion of embryonic turning (inv/inv) and the INVS (NPHP2) gene in human infantile nephronophthisis (NPH (show TENC1 ELISA Kits)).
screened 43 families with infantile nephronophthisis (ESRD less than 5 years of age) for NPHP2 and NPHP3 (show NPHP3 ELISA Kits) mutations and determined genotype-phenotype correlations
Ciliary abnormalities are associated with nphp2 mutant mice.
Loss of NPHP2 causes ciliogenesis defects.
the significance of Inversin in controlling cell migration processes
Nek8 (show NEK8 ELISA Kits) acts downstream of Inv function
Inv acts as a molecular anchor for Nphp3 (show NPHP3 ELISA Kits) and Nek8 (show NEK8 ELISA Kits) in the proximal segment of primary cilia.
the inv gene product functions in several cellular compartments, including the nucleus and cell-cell adhesion sites
Molecular cloning of a gene for inversion of embryo turning (inv) with cystic kidney. Deduced amino acid sequence shows 15 successive repeats of Ank (show ANKH ELISA Kits)/Swi6 motif in its N-terminal domain. Mutation causes situs inversus and cysts in kidney in inv mutant.
inv has a role in kidney disease: inv mutant mouse has renal cysts resembling infantile NPHP2
The localization of inversin in distal tubules in the kidney and in extrarenal tissues suggests that the expression of this protein has an important function in a variety of organs.
These results indicate that a random signal of laterality (Foxj1 (show FOXJ1 ELISA Kits)) is dominant over the reversal signal of laterality (Inv).
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
, inversion of embryo turning homolog
, inversion of embryonic turning
, inversion of embryo turning protein
, nephrocystin 2