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Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.. Additionally we are shipping Islet Amyloid Polypeptide Antibodies (124) and Islet Amyloid Polypeptide Kits (67) and many more products for this protein.
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Serum levels of preptin and amylin were significantly lower in patients with psoriasis and Behcet's disease.
These data suggest participation by both soluble and fibrillar aggregates in IAPP-induced islet inflammation. IAPP-induced activation of TLR2 and secretion of IL-1 (show IL1A Proteins) may be important therapeutic targets to prevent amyloid-associated beta cell dysfunction.
the effect of the endoplasmic reticulum chaperone protein disulfide isomerase (PDI (show P4HB Proteins)) on beta-cell dysfunction, was examined.
Data suggest that IAPP/membrane interaction strongly depends on protonation state of His18; at neutral pH, N-terminal domain is stabilized/anchored to membrane, while C-terminal domain is disordered as if in solution.
Structural studies and cytotoxicity assays of "aggregation-prone" IAPP(8-16) and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin.
Hsp72 (HSPA1A (show HSPA1A Proteins)) prevents h-IAPP aggregation and toxicity.
structural and dynamical information of amylin and CGRP (show S100A12 Proteins)
The computational models support the cross-sequence interactions between ABETA (show APP Proteins) and IAPP pentamers, which would lead to the complex hybrid ABETA (show APP Proteins)-IAPP assemblies.
Study focused on human islet amyloid polypeptide aggregates and a de novo designed short polypeptide at lipid/water and air/glass interfaces; found that parallel beta-sheets adopt distinct orientations at various interfaces and exhibit characteristic chiroptical responses in the amide I and N-H stretch regions.
Secondary Structure of Rat and Human Amylin
Hypothalamic amylin is transcriptionally regulated by leptin (show LEP Proteins), that it can act directly on ObRb (show LEPR Proteins) neurons in concert with leptin (show LEP Proteins), and that it regulates feeding.
Matrix Metalloproteinase-9 (show MMP9 Proteins) Protects Islets from Amyloid-induced Toxicity.
Data indicate that T-cell receptors that react to chromogranin A (ChgA (show CHGA Proteins)) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (show PRSS16 Proteins)).
Study the physiologic actions of IAPP on pancreatic beta cells, which secrete this peptide together with insulin (show INS Proteins) upon glucose stimulation. Explore the signaling pathways and mitogenic actions of IAPP on beta cells.
deletion of the DeltaN isoforms of p63 (show CKAP4 Proteins) or p73 (show ARHGAP24 Proteins) leads to metabolic reprogramming and regression of p53 (show TP53 Proteins)-deficient tumours through upregulation of IAPP, the gene that encodes amylin, a 37-amino-acid peptide co-secreted with insulin (show INS Proteins) by the beta cells of the pancreas
The stability, conformational dynamics and association force of different single-layer models of the full-length wild-type and glycine mutants of amylin, were investigated.
studies have identified a novel TXNIP (show TXNIP Proteins)/miR (show MLXIP Proteins)-124a/FoxA2 (show FOXA2 Proteins)/IAPP signaling cascade linking the critical beta-cell signaling pathways of TXNIP (show TXNIP Proteins) and IAPP
MMP-9 (show MMP9 Proteins) constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP.
Data suggest that amylin and leptin (show LEP Proteins) play additive roles in regulating energy homeostasis via activation of overlapping signalling pathways; mechanisms may be different in hypothalamus, muscle, and liver and in cases of endoplasmic reticulum stress.
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
islet amyloid polypeptide
, Islet amyloid polypeptide (diabetes-associated peptide; amylin)
, diabetes-associated peptide
, insulinoma amyloid peptide
, amyloid protein