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Jumonji Domain Containing 6 Proteins (JMJD6)

JMJD6 encodes a nuclear protein with a JmjC domain. Additionally we are shipping Jumonji Domain Containing 6 Antibodies (111) and Jumonji Domain Containing 6 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
JMJD6 23210 Q6NYC1
JMJD6 107817 Q9ERI5
Rat JMJD6 JMJD6 360665 Q6AYK2
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Top Jumonji Domain Containing 6 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 2 to 3 Days
$357.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Hydra His tag   1 mg Log in to see 56 to 66 Days
$3,059.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,116.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

JMJD6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Jumonji Domain Containing 6 (JMJD6) Interaction Partners

Human Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. Our studies identify JMJD6 as a molecular determinant of cancer stem cell phenotype

  2. Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer

  3. The expression of JMJD6 was reduced in T lymphocytes in chronic hepatitis B.

  4. A novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL (show VHL Proteins)-HIF1A (show HIF1A Proteins) feedback loop may indirectly contribute to elevated HIF1A (show HIF1A Proteins) found in preeclampsia.

  5. JMJD6 is a potential biomarker for colon cancer aggressiveness and a potential target for colon cancer intervention.

  6. Study reports that a unique cohort of JMJD6 and Brd4 (show BRD4 Proteins) cobound distal enhancers, termed anti-pause enhancers, regulate promoter-proximal pause release of a large subset of transcription units via long-range interactions.

  7. The structure of Jmjd6 oligomers in vitro changes in the absence of the polyS domain, possibly reflecting the role of the polyS domain in nuclear/nucleolar shuttling of Jmjd6.

  8. results showed that JMJD6 plays a key role in lung adenocarcinoma and therefore may provide an opportunity for developing a novel therapeutic target as well as a prognostic marker in lung adenocarcinoma.

  9. histones are additional substrates of JMJD6 in vivo. Because 5-hydroxylation of lysyl residues inhibited N-acetylation and N-methylation by an acetyltransferase and a methyltransferase

  10. data indicate JMJD6 has conserved functions and often affects similar pathways across multiple cell types; it has ability to promote cancer cell proliferation and motility; JMJD6 is a novel biomarker of tumor aggressiveness with functional implications in breast cancer growth and migration

Mouse (Murine) Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. Although Jmjd6 deficiency does not affect abundance of Aire (show AIRE Proteins) transcript, the intron 2 of Aire (show AIRE Proteins) gene is not effectively spliced out in the absence of Jmjd6, resulting in reduction of mature Aire (show AIRE Proteins) protein and spontaneous multi-organ autoimmunity in mice.

  2. The results indicate dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of C/EBPbeta (show CEBPB Proteins) and C/EBPdelta (show CEBPD Proteins) and direct transcriptional activation of Ppargamma2 (show PPARG Proteins) and Cebpalpha during adipocyte differentiation.

  3. histones are additional substrates of JMJD6 in vivo. Because 5-hydroxylation of lysyl residues inhibited N-acetylation and N-methylation by an acetyltransferase and a methyltransferase

  4. confirmed that Jmjd6 forms multimers and showed that nuclear localization of the protein involves association with a nucleic acid matrix

  5. protein kinase C beta (show PRKCB Proteins) activation is dependent upon phosphatidylserine receptor action

  6. data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations

  7. during embryonic development, phosphatidylserine receptor-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses

  8. Ptdsr is localized in the cell nucleus via multiple nuclear localization signals.

  9. Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell clearance.

  10. identified cardiac malformations in Ptdsr deficient embryos, including ventricular septal defects, double-outlet right ventricle, and hypoplasia of the pulmonary artery and thymus.

Zebrafish Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. results suggest that YY1a (show YY1 Proteins) regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development

  2. PSR-dependent system in zebrafish embryos that engulfs apoptotic cells mediated by PSR-phagocytes during development, with the system assuming an important role in the normal development of tissues such as the brain, heart, notochord and somite

Cow (Bovine) Jumonji Domain Containing 6 (JMJD6) interaction partners

  1. JMJD6 contributes to foot-and-mouth disease virus infectivity and may be a previously unidentified foot-and-mouth disease receptor.

  2. Demethylated RHA bound JMJD6 monomer during foot-and-mouth disease virus infection.

Jumonji Domain Containing 6 (JMJD6) Protein Profile

Protein Summary

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells\; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with JMJD6

  • jumonji domain containing 6 (LOC100230335)
  • phosphatidylserine receptor (PSR)
  • phosphatidylserine receptor (AaeL_AAEL008084)
  • phosphatidylserine receptor (AaeL_AAEL013254)
  • phosphatidylserine receptor (AaeL_AAEL013632)
  • phosphatidylserine receptor (CpipJ_CPIJ004848)
  • phosphatidylserine receptor (CpipJ_CPIJ019866)
  • jumonji domain containing 6 (jmjd6)
  • jumonji domain containing 6 (JMJD6)
  • jumonji domain containing 6 (Jmjd6)
  • jumonji domain containing 6 (jmjd6-a)
  • jumonji domain containing 6 (jmjd6-b)
  • 5730436I23Rik protein
  • cg5383 protein
  • D11Ertd195e protein
  • GB15204 protein
  • jmjd6 protein
  • mKIAA0585 protein
  • psr protein
  • PtdSerR protein
  • Ptdsr protein
  • ptdsr1 protein
  • zfpsr protein
  • zgc:66264 protein

Protein level used designations for JMJD6

jumonji domain containing 6 , phosphatidylserine receptor , Histone arginine demethylase JMJD6 , bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 , jmjC domain-containing protein 6 , jumonji domain-containing protein 6 , lysyl-hydroxylase JMJD6 , peptide-lysine 5-dioxygenase JMJD6 , histone arginine demethylase JMJD6 , apoptotic cell clearance receptor PtdSerR , bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A , histone arginine demethylase JMJD6-A , jmjC domain-containing protein 6-A , jumonji domain-containing protein 6-A , lysyl-hydroxylase JMJD6-A , peptide-lysine 5-dioxygenase JMJD6-A , phosphatidylserine receptor-A , protein PTDSR-A , bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-B , histone arginine demethylase JMJD6-B , jmjC domain-containing protein 6-B , jumonji domain-containing protein 6-B , lysyl-hydroxylase JMJD6-B , peptide-lysine 5-dioxygenase JMJD6-B , phosphatidylserine receptor-B , protein PTDSR-B , protein PTDSR

GENE ID SPECIES
100230335 Taeniopygia guttata
411069 Apis mellifera
5570116 Aedes aegypti
5577546 Aedes aegypti
5578311 Aedes aegypti
6036446 Culex quinquefasciatus
6054124 Culex quinquefasciatus
548957 Xenopus (Silurana) tropicalis
100173544 Pongo abelii
23210 Homo sapiens
107817 Mus musculus
266962 Danio rerio
444377 Xenopus laevis
417355 Gallus gallus
508343 Bos taurus
360665 Rattus norvegicus
380206 Xenopus laevis
483335 Canis lupus familiaris
468338 Pan troglodytes
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