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anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies

KEAP1 encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Kits (12) and Kelch-Like ECH-Associated Protein 1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KEAP1 9817 Q14145
KEAP1 50868 Q9Z2X8
KEAP1 117519  
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Top anti-Kelch-Like ECH-Associated Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 129 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KEAP1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KEAP1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KEAP1 Antibody Titration: 1.0ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC202189 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-KEAP1 antibody (ABIN2453954), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KEAP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-KEAP1. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated EIA, IF, WB Western blot analysis of KEAP1 in human lung tissue lysate with KEAP1 Antibody  at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated ICC, FACS, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HepG2 cells using KEAP1 mouse mAb (green) and negative control (purple) . 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HeLa cells using KEAP1 mouse mAb (green) and negative control (red) . 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB This image was generously provided by Yang Song, Ph.D. at Southwest University in Chong Qing, China. HepG2 cells were incubated with Rabbit Anti-KEAP1 Polyclonal Antibody  at 4°C overnight and then mixed with Protein A agarose beads at 4°C for 3hrs. The solutions were centrifuged and the pellets were washed with lysis buffer, heated, and subsequently analyzed by Western blotting. This image was generously provided by Yang Song, Ph.D. from Southwest University, Chong Qing, China. Human HepG2 cells incubated with Rabbit Anti-KEAP1 Polyclonal Antibody  overnight at 4˚C followed by incubation with a secondary antibody for 2hrs. Lamin B was used as a loading control. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$330.00
Details
Human Rabbit Un-conjugated IHC (p), WB KEAP1 Antibody (C-term)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KEAP1 antibody detected the KEAP1 protein (arrow). KEAP1 antibody (C-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the KEAP1 antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details

KEAP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Kelch-Like ECH-Associated Protein 1 Antibodies

  1. Human Polyclonal KEAP1 Primary Antibody for EIA, IF - ABIN1449975 : Zhang, Lo, Cross, Templeton, Hannink: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. in Molecular and cellular biology 2004 (PubMed)
    Show all 4 references for ABIN1449975

  2. Human Polyclonal KEAP1 Primary Antibody for IF (p), IHC (p) - ABIN702085 : Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015 (PubMed)
    Show all 2 references for ABIN702085

  3. Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN1098141 : Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011 (PubMed)
    Show all 2 references for ABIN1098141

  4. Human Monoclonal KEAP1 Primary Antibody for ICC, FACS - ABIN1098137 : Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010 (PubMed)
    Show all 2 references for ABIN1098137

  5. Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN2453954 : Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014 (PubMed)
    Show all 2 references for ABIN2453954

  6. Cow (Bovine) Polyclonal KEAP1 Primary Antibody for IHC, WB - ABIN2780875 : Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006 (PubMed)

More Antibodies against Kelch-Like ECH-Associated Protein 1 Interaction Partners

Human Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. Up-regulation of KEAP1 is associated with carcinogenesis and progression of Salivary Adenoid Cystic Carcinoma.

  2. Studies demonstrate that Keap1-Nrf2 (show GABPA Antibodies) pathway is important to orchestrate an elaborate genetic program that enhances the intrinsic cytoprotective functions, including drug metabolizing, antioxidant and antiinflammatory networks. [review]

  3. Studies propose that Keap1 activity and Nrf2 (show GABPA Antibodies) are regulated by interactions of Trx1 (show MLL Antibodies) system enzymes with oxidants. [review]

  4. Accumulating evidence suggests that dysregulation of Keap1-Nrf2 (show GABPA Antibodies) pathway resulting in constitutively active Nrf2 (show GABPA Antibodies) and increased expression of cytoprotective Nrf2 (show GABPA Antibodies) target genes, has a pivotal role in cancer. [review]

  5. expression of Nrf2 (show GABPA Antibodies)-Keap1 is abnormal in osteosarcoma tissue and shows significant clinical relevance for determining the prognosis of osteosarcoma

  6. that targeted repression of Keap1 and activation of Nrf2 pathway, in part, underlies the protective effects of miR-7 against 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in SH-SY5Y

  7. findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN Antibodies) independently of its role in oxidant stress responses.

  8. The Nrf2 (show GABPA Antibodies)-Keap1 pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. (Review)

  9. Keap1 functions as a suppressor of tumor metastasis by targeting the Nrf2 (show GABPA Antibodies)/S100P (show S100P Antibodies) pathway in NSCLC cells.

  10. electrophilic moiety in caffeic acid is essential for the oxidation of the Keap1 protein It (show KRT20 Antibodies) should be noted that while the nucleophilic moiety (the catechol/quinone moiety) can provide scavenging ability it cannot contribute directly to Nrf2 (show GABPA Antibodies) induction

Cow (Bovine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Antibodies) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin

Mouse (Murine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN Antibodies) independently of its role in oxidant stress responses.

  2. chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 Antibodies) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 Antibodies) production to normoglycemic levels.

  3. conclusion, increased Keap1/Nrf2 (show NFE2L2 Antibodies) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.

  4. Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.

  5. iron deficiency induced the nuclear translocation of Nrf2 (show NFE2L2 Antibodies) via Keap1 degradation by autophagy and subsequently upregulated expression of HO-1 (show HMOX1 Antibodies).

  6. These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.

  7. Keap1 knockdown caused severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes.

  8. LXR (show NR1H3 Antibodies) agonist can enhance the functional survival of transplanted AD-MSCs in infarcted myocardium, at least partially, via modulation of the TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies) and Keap-1/Nrf-2 (show NFE2L2 Antibodies) signaling pathways.

  9. data confirm a role for GNOM in endoplasmic reticulum (ER)-Golgi trafficking and reveal that a GNL1 (show GNL1 Antibodies)/GNOM-mediated early secretory pathway selectively regulates PIN1 (show PIN1 Antibodies) basal polarity establishment in a manner essential for normal plant development

  10. Results implicate p62 (show GTF2H1 Antibodies)-dependent autophagic degradation of Keap1 by palmitate as a mechanism contributing to hepatocyte lipoapoptosis.

Zebrafish Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Antibodies), indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 molecules to fully function

  2. study reports that the Keap1-Nrf2 (show NFE2L2 Antibodies) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2 (show NFE2L2 Antibodies)-activating compounds

Kelch-Like ECH-Associated Protein 1 (KEAP1) Antigen Profile

Protein Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Gene names and symbols associated with KEAP1

  • kelch-like ECH-associated protein 1 (KEAP1) antibody
  • kelch-like ECH-associated protein 1 (keap1) antibody
  • kelch-like ECH-associated protein 1 (LOC100346935) antibody
  • kelch-like ECH-associated protein 1 (Keap1) antibody
  • Kelch-like ECH-associated protein 1 (Keap1) antibody
  • kelch-like ECH-associated protein 1a (keap1a) antibody
  • fb36f11 antibody
  • Inrf2 antibody
  • keap1 antibody
  • KLHL19 antibody
  • mKIAA0132 antibody
  • wu:fb36f11 antibody

Protein level used designations for KEAP1

kelch-like ECH-associated protein 1 , cytosolic inhibitor of Nrf2 , kelch-like family member 19 , kelch-like protein 19 , NRF2 cytosolic inhibitor , ring canal protein

GENE ID SPECIES
455706 Pan troglodytes
493386 Xenopus (Silurana) tropicalis
100346935 Oryctolagus cuniculus
9817 Homo sapiens
476713 Canis lupus familiaris
100136900 Sus scrofa
532791 Bos taurus
50868 Mus musculus
117519 Rattus norvegicus
496326 Xenopus laevis
100173389 Pongo abelii
321837 Danio rerio
Selected quality suppliers for anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies
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