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anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibodies

KEAP1 encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Kits (12) and Kelch-Like ECH-Associated Protein 1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KEAP1 9817 Q14145
KEAP1 50868 Q9Z2X8
KEAP1 117519  
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Top anti-Kelch-Like ECH-Associated Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 129 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KEAP1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: ... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KEAP1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: ... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KEAP1 Antibody Titration: 1.0ug/mlPositive Control: ... 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC202189 overexpress plasmid (Re... HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane... 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated EIA, IF, WB Western blot analysis of KEAP1 in human lung tissue lysate with KEAP1 ... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated ICC, FACS, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green... Figure 2: Flow cytometric analysis of HepG2 cells using KEAP1 mouse mA... 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green... Figure 2: Flow cytometric analysis of HeLa cells using KEAP1 mouse mAb... 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB This image was generously provided by Yang Song, Ph.D. at Southwest Un... This image was generously provided by Yang Song, Ph.D. from Southwest ... 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$330.00
Details
Human Rabbit Un-conjugated IHC (p), WB KEAP1 Antibody (C-term)  western blot analysis in HepG2 cell line lysa... KEAP1 antibody (C-term)  immunohistochemistry analysis in formalin fix... 400 μL Log in to see 10 to 11 Days
$324.50
Details

KEAP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-Kelch-Like ECH-Associated Protein 1 Antibodies

  1. Human Polyclonal KEAP1 Primary Antibody for EIA, IF - ABIN1449975 : Zhang, Lo, Cross, Templeton, Hannink: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. in Molecular and cellular biology 2004 (PubMed)
    Show all 4 references for ABIN1449975

  2. Human Polyclonal KEAP1 Primary Antibody for IF (p), IHC (p) - ABIN702085 : Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015 (PubMed)
    Show all 2 references for ABIN702085

  3. Human Monoclonal KEAP1 Primary Antibody for ICC, FACS - ABIN1098137 : Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010 (PubMed)
    Show all 2 references for ABIN1098137

  4. Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN1098141 : Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011 (PubMed)
    Show all 2 references for ABIN1098141

  5. Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN2453954 : Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014 (PubMed)
    Show all 2 references for ABIN2453954

  6. Cow (Bovine) Polyclonal KEAP1 Primary Antibody for IHC, WB - ABIN2775978 : Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006 (PubMed)

More Antibodies against Kelch-Like ECH-Associated Protein 1 Interaction Partners

Human Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. Keap1 functions as a suppressor of tumor metastasis by targeting the Nrf2 (show GABPA Antibodies)/S100P (show S100P Antibodies) pathway in NSCLC cells.

  2. electrophilic moiety in caffeic acid is essential for the oxidation of the Keap1 protein It (show KRT20 Antibodies) should be noted that while the nucleophilic moiety (the catechol/quinone moiety) can provide scavenging ability it cannot contribute directly to Nrf2 (show GABPA Antibodies) induction

  3. Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.

  4. Combined genomic and proteomic analyses demonstrated infrequent alteration of validated lung cancer targets but identified novel potential targets for TTF1 (show NKX2-1 Antibodies)-negative LUAD, including KEAP1/Nrf2 (show GABPA Antibodies) and DNA repair pathways

  5. Oxidative stress and main redox regulators may participate in pancreatic carcinogenesis and Keap1 appears as a promising prognostic factor in pancreatic cancer.

  6. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1 (show CAND1 Antibodies)), COP9 (show COPS8 Antibodies) signalosome (CSN), neddylated cullin 3 (Cul3 (show CUL3 Antibodies)) and the BTB protein Keap1.

  7. Data suggest that persistent aromatase (show CYP19A1 Antibodies) inhibitor treatment downregulated INrf2 (Keap1) protein leading to higher expression of nuclear factor E2-related factor 2 (Nrf2 (show GABPA Antibodies)).

  8. In cells with functional KEAP1, RTA (show RBM9 Antibodies) 405 increased NRF2 (show GABPA Antibodies) levels, but not IKKbeta (show IKBKB Antibodies) or BCL2 (show BCL2 Antibodies) levels, and did not increase cell proliferation or survival.

  9. There were differences in the expression of Nrf2 (show GABPA Antibodies), Keap1, p16 (show CDKN2A Antibodies) and E-cadherin (show CDH1 Antibodies) between different ovarian carcinoma subtypes.

  10. here we report that genetic variants in the KEAP1 gene were associated with the outcome of patients with breast cancer

Cow (Bovine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Antibodies) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin

Mouse (Murine) Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 Antibodies) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 Antibodies) production to normoglycemic levels.

  2. conclusion, increased Keap1/Nrf2 (show NFE2L2 Antibodies) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.

  3. Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.

  4. iron deficiency induced the nuclear translocation of Nrf2 (show NFE2L2 Antibodies) via Keap1 degradation by autophagy and subsequently upregulated expression of HO-1 (show HMOX1 Antibodies).

  5. These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.

  6. Keap1 knockdown caused severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes.

  7. LXR (show NR1H3 Antibodies) agonist can enhance the functional survival of transplanted AD-MSCs in infarcted myocardium, at least partially, via modulation of the TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies) and Keap-1/Nrf-2 (show NFE2L2 Antibodies) signaling pathways.

  8. data confirm a role for GNOM in endoplasmic reticulum (ER)-Golgi trafficking and reveal that a GNL1 (show GNL1 Antibodies)/GNOM-mediated early secretory pathway selectively regulates PIN1 (show PIN1 Antibodies) basal polarity establishment in a manner essential for normal plant development

  9. Results implicate p62 (show GTF2H1 Antibodies)-dependent autophagic degradation of Keap1 by palmitate as a mechanism contributing to hepatocyte lipoapoptosis.

  10. Coordinated regulation of KEAP1-NRF2 (show NFE2L2 Antibodies)-ARE and p53 (show TP53 Antibodies)/p21 (show D4S234E Antibodies) signaling pathways was associated with compensatory liver regeneration.

Zebrafish Kelch-Like ECH-Associated Protein 1 (KEAP1) interaction partners

  1. mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Antibodies), indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 molecules to fully function

  2. study reports that the Keap1-Nrf2 (show NFE2L2 Antibodies) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2 (show NFE2L2 Antibodies)-activating compounds

Kelch-Like ECH-Associated Protein 1 (KEAP1) Antigen Profile

Protein Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Gene names and symbols associated with KEAP1

  • kelch-like ECH-associated protein 1 (KEAP1) antibody
  • kelch-like ECH-associated protein 1 (keap1) antibody
  • kelch-like ECH-associated protein 1 (LOC100346935) antibody
  • kelch-like ECH-associated protein 1 (Keap1) antibody
  • Kelch-like ECH-associated protein 1 (Keap1) antibody
  • kelch-like ECH-associated protein 1a (keap1a) antibody
  • fb36f11 antibody
  • Inrf2 antibody
  • keap1 antibody
  • KLHL19 antibody
  • mKIAA0132 antibody
  • wu:fb36f11 antibody

Protein level used designations for KEAP1

kelch-like ECH-associated protein 1 , cytosolic inhibitor of Nrf2 , kelch-like family member 19 , kelch-like protein 19 , NRF2 cytosolic inhibitor , ring canal protein

GENE ID SPECIES
455706 Pan troglodytes
493386 Xenopus (Silurana) tropicalis
100346935 Oryctolagus cuniculus
9817 Homo sapiens
476713 Canis lupus familiaris
100136900 Sus scrofa
532791 Bos taurus
50868 Mus musculus
117519 Rattus norvegicus
496326 Xenopus laevis
100173389 Pongo abelii
321837 Danio rerio
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