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KEAP1 encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Additionally we are shipping Kelch-Like ECH-Associated Protein 1 Kits (12) and Kelch-Like ECH-Associated Protein 1 Proteins (9) and many more products for this protein.
Showing 10 out of 137 products:
Human Polyclonal KEAP1 Primary Antibody for EIA, IF - ABIN1449975
Zhang, Lo, Cross, Templeton, Hannink: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. in Molecular and cellular biology 2004
Show all 4 references for ABIN1449975
Human Polyclonal KEAP1 Primary Antibody for IF (p), IHC (p) - ABIN702085
Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015
Show all 3 references for ABIN702085
Human Monoclonal KEAP1 Primary Antibody for ICC, FACS - ABIN1098137
Kim, You, Lee, Ahn, Seong, Hwang: Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. in Cellular signalling 2010
Show all 2 references for ABIN1098137
Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN1098141
Muscarella, Barbano, DAngelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. in Epigenetics 2011
Show all 2 references for ABIN1098141
Human Monoclonal KEAP1 Primary Antibody for FACS, IHC - ABIN2453954
Mercado, Kizawa, Ueda, Xiong, Kimura, Moses, Curtis, Ito, Barnes: Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers. in PLoS ONE 2014
Show all 2 references for ABIN2453954
Cow (Bovine) Polyclonal KEAP1 Primary Antibody for IHC, WB - ABIN2775979
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
c-myc (show MYC Antibodies) plays a key role in MBD1 (show DPEP1 Antibodies) mediated epigenetic silencing of KEAP1.
Results show up-regulation of TrkB (show NTRK2 Antibodies) and down-regulation of Runx3 (show RUNX3 Antibodies) and Keap1 in breast cancer cells and suggest that TrkB (show NTRK2 Antibodies) plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 (show RUNX3 Antibodies) or Keap1.
Inhibition of NRF2 (show GABPA Antibodies) by KEAP1 overexpression compromises metabolic reprogramming of fibroblasts and results in reduced efficiency of induced pluripotent stem cells colony formation.
Induction of GSH-related genes xCT (show SLC7A11 Antibodies) and GCLM (show GCLM Antibodies) were oxygen and Bach1 (show BACH1 Antibodies)-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2 (show GABPA Antibodies)-Keap1 defense pathway
Up-regulation of KEAP1 is associated with carcinogenesis and progression of Salivary Adenoid Cystic Carcinoma.
Studies demonstrate that Keap1-Nrf2 (show GABPA Antibodies) pathway is important to orchestrate an elaborate genetic program that enhances the intrinsic cytoprotective functions, including drug metabolizing, antioxidant and antiinflammatory networks. [review]
Studies propose that Keap1 activity and Nrf2 (show GABPA Antibodies) are regulated by interactions of Trx1 (show MLL Antibodies) system enzymes with oxidants. [review]
Accumulating evidence suggests that dysregulation of Keap1-Nrf2 (show GABPA Antibodies) pathway resulting in constitutively active Nrf2 (show GABPA Antibodies) and increased expression of cytoprotective Nrf2 (show GABPA Antibodies) target genes, has a pivotal role in cancer. [review]
expression of Nrf2 (show GABPA Antibodies)-Keap1 is abnormal in osteosarcoma tissue and shows significant clinical relevance for determining the prognosis of osteosarcoma
that targeted repression of Keap1 and activation of Nrf2 pathway, in part, underlies the protective effects of miR-7 against 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in SH-SY5Y
the potency of 15d-PGJ2 as a signalling molecule (show GDF5 Antibodies) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
Caffeic acid induces Nrf2 (show NFE2L2 Antibodies) activation by decreasing the expression of its inhibitor protein Keap1 and blocking the binding of Nrf2 (show NFE2L2 Antibodies) with Keap1.
Hepatocyte-specific deletion of Keap1 triggering constitutive Nrf2 (show NFE2L2 Antibodies) activation shifts hepatic metabolism towards increased lipid catabolism, reduced liponeogenesis and activation of the pentose phosphate pathway.
findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin (show CTTN Antibodies) independently of its role in oxidant stress responses.
chronic hyperglycemic conditions, Keap1 inhibition increased Nrf2 (show NFE2L2 Antibodies) nuclear translocation, increased antioxidant gene expression, and reduced ROS (show ROS1 Antibodies) production to normoglycemic levels.
conclusion, increased Keap1/Nrf2 (show NFE2L2 Antibodies) signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice.
Keap1 utilizes multiple cysteine residues specifically and/or collaboratively as sensors for the detection of a wide range of environmental stresses.
iron deficiency induced the nuclear translocation of Nrf2 (show NFE2L2 Antibodies) via Keap1 degradation by autophagy and subsequently upregulated expression of HO-1 (show HMOX1 Antibodies).
These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.
Keap1 knockdown caused severe disruption in both the redox cycle and the cell cycle of replicating hepatocytes.
LXR (show NR1H3 Antibodies) agonist can enhance the functional survival of transplanted AD-MSCs in infarcted myocardium, at least partially, via modulation of the TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies) and Keap-1/Nrf-2 (show NFE2L2 Antibodies) signaling pathways.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (show NFE2L2 Antibodies), indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 (show NFE2L2 Antibodies) system comprises discrete sensor sites, including the Keap1 cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2 (show NFE2L2 Antibodies)-activating compounds
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
kelch-like ECH-associated protein 1
, cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein