anti-Kelch-Like 3 (Drosophila) (KLHL3) Antibodies

KLHL3 is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. Additionally we are shipping KLHL3 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KLHL3 100503085  
KLHL3 26249 Q9UH77
KLHL3 498697  
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Top anti-KLHL3 Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Sample Type : Human brain stem cells Primary Antibody Dilution : 1:500 Secondary Antibody : Goat anti-rabbit Alexa-Fluor 594 Secondary Antibody Dilution : 1:1000 Color/Signal Descriptions : KLHL3: Red DAPI:Blue Gene Name : KLHL3 Submitted by : Dr. Yuzhi Chen, University of Arkansas for Medical Science WB Suggested Anti-KLHL3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KLHL3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KLHL3 Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate WB Suggested Anti-KLHL3  Antibody Titration: 1.25 µg/mL ELISA Titer: 1:62500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KLHL3 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of A549 cells, using KLHL3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB KLHL3 Antibody (Center)  western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the KLHL3 antibody detected the KLHL3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Bat Rabbit Un-conjugated IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$676.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded rat kidney, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with KLHL3 Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Log in to see 3 to 7 Days
$295.90
Details

KLHL3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-KLHL3 Antibodies

  1. Cow (Bovine) Polyclonal KLHL3 Primary Antibody for IHC, WB - ABIN2775874 : Schmutz, Martin, Terry, Couronne, Grimwood, Lowry, Gordon, Scott, Xie, Huang, Hellsten, Tran-Gyamfi, She, Prabhakar, Aerts, Altherr, Bajorek, Black, Branscomb, Caoile, Challacombe, Chan, Denys et al.: The DNA sequence and comparative analysis of human chromosome 5. ... in Nature 2004 (PubMed)

  2. Cow (Bovine) Polyclonal KLHL3 Primary Antibody for WB - ABIN2781023 : Lai, Orelli, Till, Godley, Fernald, Pamintuan, Le Beau: Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene. in Genomics 2000 (PubMed)

More Antibodies against KLHL3 Interaction Partners

Mouse (Murine) Kelch-Like 3 (Drosophila) (KLHL3) interaction partners

  1. However, phosphorylation of SPAK (show STK39 Antibodies) and NCC (show SLC12A3 Antibodies) at distal convoluted tubules were almost completely absent even in WNK4 (show WNK4 Antibodies)(-/-)KLHL3(R528H/R528H) mice. In conclusion, increased WNK1 (show WNK1 Antibodies) was unable to compensate for WNK4 (show WNK4 Antibodies) deficiency and phosphorylate the NCC (show SLC12A3 Antibodies), indicating that WNK4 (show WNK4 Antibodies) is indispensable for the onset of PHAII.

  2. the heterozygous deletion of KLHL3 was not sufficient to cause PHAII, indicating that autosomal dominant type pseudohypoaldosteronism type II (PHAII) is caused by the dominant negative effect of mutant KLHL3.

  3. Potassium depletion stimulates NCC (show SLC12A3 Antibodies) via phosphorylation and inactivation of the KLHL3 and promoting increased blood pressure.

  4. KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8 (show CLDN8 Antibodies)

  5. increased protein expression levels of WNK1 (show WNK1 Antibodies) and WNK4 (show WNK4 Antibodies) kinases cause PHAII by KLHL3 R528H mutation due to impaired KLHL3-Cullin3-mediated ubiquitination.

Human Kelch-Like 3 (Drosophila) (KLHL3) interaction partners

  1. Mutation in the KLHL3 gene is associated with Gordon syndrome.

  2. The results demonstrate that Hcy decreases the expression of cMyBP-C through a KLHL3-mediated ubiquitin-proteasome pathway, and thereby influences heart development.

  3. This study provides substantial new insights into the role of phosphorylation of KLHL3 in regulating the interaction with WNK4 (show WNK4 Antibodies)

  4. Data indicate that WNK lysine deficient protein kinase 4 protein (WNK4) was degraded not only by proteasomes but also by atypical protein kinase C scaffold protein p62 (p62)-kelch-like 3 protein (KLHL3)-mediated selective autophagy.

  5. Familial hyperkalemia and hypertension caused by KLHL3 mutations is accompanied by hypercalciuria as well as hyperkalemia and hypertension.

  6. Akt (show AKT1 Antibodies) and PKA phosphorylated KLHL3 at S433, and phosphorylation of KLHL3 by PKA inhibited WNK4 (show WNK4 Antibodies) degradation.

  7. KLHL3 is phosphorylated at serine 433 in the Kelch domain (a site frequently mutated in hypertension with hyperkalemia) by protein kinase C (show PKC Antibodies) in cultured cells and that this phosphorylation prevents WNK4 (show WNK4 Antibodies) binding and degradation.

  8. Hyperkalemic hypertension-associated cul3 (show CUL3 Antibodies) mutations depletes KLHL3, preventing WNK degradation, despite increased CUL3 (show CUL3 Antibodies)-mediated WNK ubiquitylation.

  9. CUL3 (show CUL3 Antibodies) and KLHL3 gene products are physiologically important regulators of thiazide-sensitive distal nephron sodium chloride reabsorption.

  10. analysis of how mutations of KLHL3 show less ability to ubiquitinate WNK4 (show WNK4 Antibodies) because of KLHL3's low stability and/or decreased binding to CUL3 (show CUL3 Antibodies) or WNK4 (show WNK4 Antibodies)

KLHL3 Antigen Profile

Protein Summary

This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D)\; a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with KLHL3

  • kelch-like 3 (Drosophila) (KLHL3) antibody
  • kelch-like 3 (Klhl3) antibody
  • kelch-like family member 3 (KLHL3) antibody
  • kelch-like family member 3 (Klhl3) antibody
  • 7530408C15Rik antibody
  • AI430941 antibody
  • EG627648 antibody
  • PHA2D antibody
  • RGD1565218 antibody

Protein level used designations for KLHL3

kelch-like protein 3 , kelch-like 3

GENE ID SPECIES
100174246 Pongo abelii
100503085 Mus musculus
416303 Gallus gallus
481523 Canis lupus familiaris
100519539 Sus scrofa
26249 Homo sapiens
533364 Bos taurus
498697 Rattus norvegicus
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