anti-Ketohexokinase (KHK) Antibodies

KHK encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. Additionally we are shipping Ketohexokinase Proteins (17) and Ketohexokinase Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KHK 16548 P97328
KHK 25659 Q02974
KHK 3795 P50053
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Top anti-Ketohexokinase Antibodies at antibodies-online.com

Showing 10 out of 121 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB The anti-KHK Pab (ABIN391088) is used in Western blot to detect KHK in mouse liver tissue lysate (Lane 1) and 293 cell lysate (Lane 2). Western blot analysis of KHK (arrow) using rabbit polyclonal Ketohexokinase (KHK) Antibody (N-term) (ABIN391088). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the KHK gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB The anti-KHK Pab (ABIN391089) is used in Western blot to detect KHK in mouse kidney tissue lysate. Western blot analysis of KHK (arrow) using rabbit polyclonal Ketohexokinase (KHK) Antibody (C-term) (ABIN391089). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the KHK gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB The anti-KHK Pab is used in Western blot to detect KHK in mouse liver tissue lysate (Lane 1) and 293 cell lysate (Lane 2). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated EIA, WB The anti-KHK Pab is used in Western blot to detect KHK in mouse kidney tissue lysate 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Ketohexokinase Antibody [NBP1-85790] - Staining of human cell line U-2 OS shows positivity in cytoplasm. Immunohistochemistry-Paraffin: Ketohexokinase Antibody [NBP1-85790] - Staining of human kidney shows strong nuclear and cytoplasmic positivity in cells in tubules. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.78 KDa) . 50 μL Log in to see 11 to 12 Days
$298.57
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 7 to 9 Days
$493.17
Details

KHK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Ketohexokinase Antibodies

  1. Human Polyclonal KHK Primary Antibody for ELISA, WB - ABIN561590 : DAmour, Agulnick, Eliazer, Kelly, Kroon, Baetge: Efficient differentiation of human embryonic stem cells to definitive endoderm. in Nature biotechnology 2005 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal KHK Primary Antibody for IHC, IHC (p) - ABIN4328612 : Ishimoto, Lanaspa, Le, Garcia, Diggle, Maclean, Jackman, Asipu, Roncal-Jimenez, Kosugi, Rivard, Maruyama, Rodriguez-Iturbe, Sánchez-Lozada, Bonthron, Sautin, Johnson: Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal KHK Primary Antibody for WB - ABIN391089 : Springer, Lindbloom-Hawley, Schermerhorn: Tissue expression of ketohexokinase in cats. in Research in veterinary science 2009 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal KHK Primary Antibody for ELISA, WB - ABIN561589 : Levi, Cheng, Gheysens, Patel, Chan, Wang, Namavari, Gambhir: Fluorescent fructose derivatives for imaging breast cancer cells. in Bioconjugate chemistry 2007 (PubMed)

  5. Cow (Bovine) Polyclonal KHK Primary Antibody for WB - ABIN2776884 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

More Antibodies against Ketohexokinase Interaction Partners

Mouse (Murine) Ketohexokinase (KHK) interaction partners

  1. This studies provided the first evidence that fructokinase modulates vasopressin (show AVP Antibodies) synthesis in the SON and secretion from the posterior pituitary into circulation.

  2. Fructokinase knockout mice were protected from renal injury both at baseline and after high salt intake (3 wk) compared with wild-type mice. This was associated with higher levels of active (phosphorylated serine 1177) endothelial nitric oxide synthase (show NOS3 Antibodies) in their kidneys.

  3. Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 (show SLC2A5 Antibodies) and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.

  4. Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5 (show SLC2A5 Antibodies), probably by endogenous synthesis of fructose.

  5. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Antibodies)) activation of SF3B1 (show SF3B1 Antibodies) and SF3B1 (show SF3B1 Antibodies)-mediated splice switching of KHK-A to KHK-C

  6. Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway.

  7. This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin (show INS Antibodies) resistance induced by high fructose, a widespread component of Western diets.

  8. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.

  9. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.

  10. Fructose-induced metabolic syndrome is prevented in mice lacking both fructokinase B and A but is exacerbated in mice lacking fructokinase A.

Human Ketohexokinase (KHK) interaction partners

  1. Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C.

  2. compared with normal hepatocytes, hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc (show MYC Antibodies)-dependent and heterogeneous nuclear ribonucleoprotein (show PCBP2 Antibodies) (hnRNP (show HNRNPC Antibodies)) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform.

  3. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Antibodies)) activation of SF3B1 (show SF3B2 Antibodies) and SF3B1 (show SF3B2 Antibodies)-mediated splice switching of KHK-A to KHK-C

  4. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.

  5. This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 (show SLC2A2 Antibodies) and SLC2A5 (show SLC2A5 Antibodies) and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes.

  6. In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose.

  7. ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria.

  8. The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma (show MOK Antibodies)

  9. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.

  10. The structure of the KHK-A ternary complex revealed an active site with fructose & the ATP analogue in positions ready for phosphorylation. The effects of the pathogenic mutations Gly40Arg & Ala43Thr have been modelled in the context of the KHK structure.

Ketohexokinase (KHK) Antigen Profile

Protein Summary

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with anti-Ketohexokinase (KHK) Antibodies

  • ketohexokinase-like (LOC100055449) antibody
  • ketohexokinase (khk) antibody
  • ketohexokinase (KHK) antibody
  • ketohexokinase (Hhal_0921) antibody
  • ketohexokinase (AaeL_AAEL006316) antibody
  • Ketohexokinase (Nwat_0240) antibody
  • Ketohexokinase (khk) antibody
  • ketohexokinase (LOC100351729) antibody
  • ketohexokinase (Khk) antibody
  • ketohexokinase (fructokinase) (KHK) antibody
  • ketohexokinase-like (LOC100523241) antibody
  • KETHPRO antibody
  • khk antibody
  • wu:fj68h03 antibody
  • zgc:92219 antibody
  • zgc:92626 antibody

Protein level used designations for anti-Ketohexokinase (KHK) Antibodies

ketohexokinase , Ketohexokinase , hepatic fructokinase

GENE ID SPECIES
100055449 Equus caballus
436909 Danio rerio
698328 Macaca mulatta
4710193 Halorhodospira halophila SL1
5567860 Aedes aegypti
9391692 Nitrosococcus watsonii C-113
100306748 Salmo salar
100351729 Oryctolagus cuniculus
16548 Mus musculus
25659 Rattus norvegicus
3795 Homo sapiens
100170647 Canis lupus familiaris
614868 Bos taurus
100447147 Pongo abelii
100523241 Sus scrofa
Selected quality suppliers for anti-Ketohexokinase (KHK) Antibodies
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