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KHK encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. Additionally we are shipping Ketohexokinase Proteins (17) and Ketohexokinase Kits (6) and many more products for this protein.
Showing 10 out of 112 products:
Human Polyclonal KHK Primary Antibody for ELISA, WB - ABIN561590
DAmour, Agulnick, Eliazer, Kelly, Kroon, Baetge: Efficient differentiation of human embryonic stem cells to definitive endoderm. in Nature biotechnology 2005
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Human Polyclonal KHK Primary Antibody for IHC, IHC (p) - ABIN4328612
Ishimoto, Lanaspa, Le, Garcia, Diggle, Maclean, Jackman, Asipu, Roncal-Jimenez, Kosugi, Rivard, Maruyama, Rodriguez-Iturbe, Sánchez-Lozada, Bonthron, Sautin, Johnson: Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. in Proceedings of the National Academy of Sciences of the United States of America 2012
Show all 3 references for ABIN4328612
Human Polyclonal KHK Primary Antibody for EIA, WB - ABIN359149
Hayward, Bonthron: Structure and alternative splicing of the ketohexokinase gene. in European journal of biochemistry / FEBS 1998
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Human Polyclonal KHK Primary Antibody for WB - ABIN391088
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 2 references for ABIN391088
Human Polyclonal KHK Primary Antibody for WB - ABIN391089
Springer, Lindbloom-Hawley, Schermerhorn: Tissue expression of ketohexokinase in cats. in Research in veterinary science 2009
Show all 2 references for ABIN391089
Human Polyclonal KHK Primary Antibody for WB - ABIN2776884
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Cow (Bovine) Polyclonal KHK Primary Antibody for IHC, WB - ABIN2776775
Hwa, Kim, Goo, Park, Kim, Chung, Park, Chang, Kim, Kim, Cho, Choi, Kang: The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma. in Proteomics 2006
Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 (show SLC2A5 Antibodies) and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.
Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5 (show SLC2A5 Antibodies), probably by endogenous synthesis of fructose.
myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Antibodies)) activation of SF3B1 (show SF3B1 Antibodies) and SF3B1 (show SF3B1 Antibodies)-mediated splice switching of KHK-A to KHK-C
Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway.
This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin (show INS Antibodies) resistance induced by high fructose, a widespread component of Western diets.
These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.
Fructose-induced metabolic syndrome is prevented in mice lacking both fructokinase B and A but is exacerbated in mice lacking fructokinase A.
These studies are the first demonstration that neither Khk isoform is required for normal growth and development.
compared with normal hepatocytes, hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc (show MYC Antibodies)-dependent and heterogeneous nuclear ribonucleoprotein (show PCBP2 Antibodies) (hnRNP (show HNRNPC Antibodies)) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform.
myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Antibodies)) activation of SF3B1 (show SF3B2 Antibodies) and SF3B1 (show SF3B2 Antibodies)-mediated splice switching of KHK-A to KHK-C
This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 (show SLC2A2 Antibodies) and SLC2A5 (show SLC2A5 Antibodies) and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes.
In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose.
ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria.
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma (show MOK Antibodies)
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.
The structure of the KHK-A ternary complex revealed an active site with fructose & the ATP analogue in positions ready for phosphorylation. The effects of the pathogenic mutations Gly40Arg & Ala43Thr have been modelled in the context of the KHK structure.
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.
, hepatic fructokinase