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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteins (17) and Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Kits (4) and many more products for this protein.
Showing 10 out of 197 products:
Mouse (Murine) Monoclonal KLRK1 Primary Antibody for BR, FACS - ABIN2661982
Gilfillan, Ho, Cella, Yokoyama, Colonna: NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. in Nature immunology 2002
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Human Monoclonal KLRK1 Primary Antibody for FACS - ABIN120295
Bauer, Groh, Wu, Steinle, Phillips, Lanier, Spies: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. in Science (New York, N.Y.) 1999
Show all 6 references for ABIN120295
Human Monoclonal KLRK1 Primary Antibody for Func, FACS - ABIN120293
Groh, Bruhl, El-Gabalawy, Nelson, Spies: Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Human Monoclonal KLRK1 Primary Antibody for FACS, IHC (fro) - ABIN120294
Wu, Song, Bakker, Bauer, Spies, Lanier, Phillips: An activating immunoreceptor complex formed by NKG2D and DAP10. in Science (New York, N.Y.) 1999
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Human Monoclonal KLRK1 Primary Antibody for FACS - ABIN320264
Das, Sugita, Brenner: Mechanisms of Vdelta1 gammadelta T cell activation by microbial components. in Journal of immunology (Baltimore, Md. : 1950) 2004
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Human Polyclonal KLRK1 Primary Antibody for IF (p), IHC (p) - ABIN730078
Mozer-Lisewska, Mania, Kowala-Piaskowska, Kluk, Samara, Pauli, ?eromski: Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers. in Archivum immunologiae et therapiae experimentalis 2014
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Human Polyclonal KLRK1 Primary Antibody for ELISA, WB - ABIN250553
Han, Zhang, Li, Chen, Zhang, Wan, Cao: KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. in Blood 2004
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Human Polyclonal KLRK1 Primary Antibody for ELISA, WB - ABIN185435
Hayakawa, Smyth: Innate immune recognition and suppression of tumors. in Advances in cancer research 2006
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data suggest that STAT3 contributes to NK cell recognition by modulating NKG2D ligands in K562/AO2 cells, which may a mechanism by which cells survive and cause relapse of leukemia.
These results suggest that NKG2D-DAP10 (show HCST Antibodies) endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.
The reduced cell surface expression of NKG2D in response to engagement by MICA (show MICA Antibodies)-129Met variants appeared to reduce the severity of acute graft-versus-host disease.
Bispecific protein rG7S-MICA (show MICA Antibodies) recruits natural killer cells and enhances NKG2D-mediated immunosurveillance against hepatocellular carcinoma.
Taken together, these results demonstrate that endogenous levels of IFN-alpha (show IFNA Antibodies) secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4 (show CD4 Antibodies)+ primary T cells via the engagement of NKp46 (show NCR1 Antibodies) and NKG2D.
these findings suggest that TGFbetainduced release of soluble MICA (show MICA Antibodies) leads to downregulation of NKG2D, thereby preventing NK cellmediated cytotoxicity toward renal proximal tubular epithelial cells in renal IRI
In conclusion DNT (show NT5C Antibodies) cell can significantly inhibit the growth of pancreatic carcinoma in vivo, and the mechanism may be involved in abnormal expressions of MICA (show MICA Antibodies) and NKG2D.
study indicates a direct NKG2D-dependent stimulatory effect of human CD34+ cells on allogeneic NK cells. These findings may be relevant to the NK-mediated rejection effect in HLA-mismatched hematopoietic stem cell transplantation
Both mRNA and protein levels of NKG2D, MICA (show MICA Antibodies), MICB (show MICB Antibodies) and ULBP were upregulated in six types of thymomas compared with those in atrophic thymus or proliferating thymus.
GSK-3 (show GSK3b Antibodies) undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D and 2B4 (show CD244 Antibodies), either individually or in combination.
These results support the conclusion that svH1C mimics Neu5Ac-containing sequences and interacts with cell-surface receptor NKG2D, which contains a lectin-like domain
These results indicate that, unlike in the pancreas, NKG2D-NKG2D ligand interaction does not play a critical role in obesity-induced inflammation in the adipose tissue.
The results show that NK cells and the NKG2D receptor play a role in control of lymphomas, and that selection of NKG2D-ligand (MULT1 (show ULBP1 Antibodies)) loss mutants provides a mechanism for tumor escape.
these data support a novel role for NKG2D expression by CD8 (show CD8A Antibodies)(+) T cells during allogeneic HSCT, which could be potentially therapeutically exploited to separate GVHD from GVT effects.
NKG2D and NKG2DL are involved in allergen-induced activation of dendritic epidermal T cells and the NKG2D/NKG2DL pathway might be a potential target for treatment of contact hypersensitivity.
Viral infection of cultured cells increased RAE-1 (show RAE1 Antibodies) expression, resulting in enhanced NK cell-mediated killing through NKG2D recognition.
Activation through the NKG2D receptor leads to the differential activation of the NF-kappaB (show NFKB1 Antibodies) signaling pathway and potentially enhances the anti-tumor and anti-viral functions of effector CD8 (show CD8A Antibodies)(+) T cells.
Desiccating stress-induced chemokine (show CCL1 Antibodies) expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 (show RAE1 Antibodies) and release of IFN-gamma (show IFNG Antibodies) in experimental dry eye.
Highly target-specific liver NKT (show CTSL1 Antibodies) cells selectively remove activated hepatic stellate cells through an NKG2D-Rae1 (show RAE1 Antibodies) interaction to ameliorate liver fibrosis after IL-30 treatment.
a protective role of NKG2D-activated natural killer cells in coxsackievirus B3 myocarditis leading to an effective virus clearance
The effect of Bacillus cereus on the stress response of enterocytes, including the expression of NKG2D, is reported.
Determined expressions of NKG2D in decidual natural killer cells in patients having spontaneous abortions.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
killer cell lectin-like receptor subfamily K, member 1
, NKG2-D type II integral membrane protein-like
, NK cell receptor D
, NKG2-D type II integral membrane protein
, NKG2-D-activating NK receptor
, natural killer cell group 2D
, NK lectin-like receptor
, NKR-P2, ortholog of human NKG2D
, killer cell lectin-like receptor subfamily K member 1
, NKG2-D activating NK receptor