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C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily F, Member 2 Antibodies (18) and many more products for this protein.
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NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk (show SYK Proteins), although Syk (show SYK Proteins) appears not to be recruited to NKp65.
Key residues at the membrane-distal surface of KACL (show CLEC2A Proteins), but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin (show MBL2 Proteins)-like receptor KACL (show CLEC2A Proteins) with its high-affinity receptor NKp65
structure explains the exceptionally high affinity of the NKp65-KACL (show CLEC2A Proteins) interaction compared with other cell-cell interaction pairs, which may compensate for the monomeric nature of NKp65 to achieve cell activation
Keratinocytes express KACL (show CLEC2A Proteins) and are capable of stimulating NKp65-expressing cells in a KACL (show CLEC2A Proteins)-dependent manner.
C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.
activating coreceptor NKp65
, killer cell lectin-like receptor subfamily F member 2
, lectin-like receptor F2