You are viewing an incomplete version of our website. Please click to reload the website as full version.

Kinase Suppressor of Ras 1 Proteins (KSR1)

Location-regulated scaffolding protein connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 1 Antibodies (99) and Kinase Suppressor of Ras 1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KSR1 16706 Q61097
Rat KSR1 KSR1 360573  
KSR1 8844 Q8IVT5
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Kinase Suppressor of Ras 1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

KSR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Kinase Suppressor of Ras 1 (KSR1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. the atypical C1 domain, the CC-SAM (show TTN Proteins) domain is required to target KSR-1 to the plasma membrane.

  2. KSR is a scaffold required for activation of the ERK/MAPK (show MAPK1 Proteins) module.

  3. Review discusses the possibility that KSR, a RAF (show ARAF Proteins)-like protein, does not solely act as a scaffold, but directly induces RAF (show RAF1 Proteins) catalytic function by a kinase-independent mechanism apparently shared by RAF (show RAF1 Proteins)-like proteins.

Mouse (Murine) Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.

  2. propose that phosphorylation of Tyr (show TYR Proteins)(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses

  3. Data indicate that phosphorylation of BRAF (show BRAF Proteins) by AMPK (show PRKAA1 Proteins) disrupts its association with KSR1.

  4. Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR (show FRAP1 Proteins)-dependent T cell differentiation.

  5. Ksr1 plays a dispensable role in lipopolysaccharide (LPS (show TLR4 Proteins))-induced ERK (show EPHB2 Proteins) activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS (show TLR4 Proteins) model.

  6. the atypical C1 domain, the CC-SAM (show TTN Proteins) domain is required to target KSR-1 to the plasma membrane.

  7. The loss of Ksr1 inhibits Ras/Mapk (show MAPK1 Proteins) pathway signaling leading to increased Myc (show MYC Proteins)-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.

  8. a model whereby MARK2 (show MARK2 Proteins) negatively regulates insulin (show INS Proteins) sensitivity in peripheral tissue through inhibition of KSR1

  9. Genetic disruption of KSR1 results in striking reductions in kit-ligand (show KITLG Proteins)-mediated proliferation & degranulation and impacts the biochemical activation of p21-activated kinase.

  10. Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability.

Human Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. the relative mRNA copy values of KSR1, ERK1 and ERK2 in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer

  2. KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha (show ESR1 Proteins)+ BC treated with adjuvant TAM (show CCNA1 Proteins).

  3. KSR1 is coordinately regulated with Notch (show NOTCH1 Proteins) signaling and oxidative phosphorylation in papillary thyroid cancer.

  4. KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 (show BARD1 Proteins) abundance and increased BRCA1-BARD1 (show BARD1 Proteins) interaction

  5. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.

  6. Data indicate that phosphorylation of BRAF (show BRAF Proteins) by AMPK (show PRKAA1 Proteins) disrupts its association with KSR1.

  7. Our findings integrate KSR1 into a network involving DBC1 (show DBC1 Proteins) and SIRT1 (show SIRT1 Proteins), which results in the regulation of p53 (show TP53 Proteins) acetylation and its transcriptional activity.

  8. Elevated levels of phosphorylated KSR were detected in the nuclear fractions.

  9. the atypical C1 domain, the CC-SAM (show TTN Proteins) domain is required to target KSR-1 to the plasma membrane.

  10. VRK2A can form a high molecular size complex with both MEK1 (show MAP2K1 Proteins) and KSR1; the KSR1 complex assembled and retained by VRK2A in the endoplasmic reticulum can have a modulatory effect on the signal mediated by MAPK (show MAPK1 Proteins),locally affecting the magnitude of its responses

Kinase Suppressor of Ras 1 (KSR1) Protein Profile

Protein Summary

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Gene names and symbols associated with KSR1

  • kinase suppressor of ras 1 (KSR1)
  • kinase suppressor of ras (ksr)
  • kinase suppressor of ras 1 (Ksr1)
  • AW492498 protein
  • B-KSR1 protein
  • CG2899 protein
  • D11Bhm183e protein
  • D11Bhm184e protein
  • dKsr protein
  • Dmel\\CG2899 protein
  • EK3-1 protein
  • hb protein
  • Ksr protein
  • Ksr-1 protein
  • l(3)j5E2 protein
  • RSU2 protein
  • SR3-1 protein

Protein level used designations for KSR1

CG2899-PA , kinase suppressor of Ras85D , ksr-PA , suppressor of Ras1 3-1 , kinase suppressor of Ras 1 , mKSR1 , protein Hb

GENE ID SPECIES
100071912 Equus caballus
40660 Drosophila melanogaster
16706 Mus musculus
360573 Rattus norvegicus
8844 Homo sapiens
427839 Gallus gallus
610451 Canis lupus familiaris
100511282 Sus scrofa
100138565 Bos taurus
Selected quality suppliers for Kinase Suppressor of Ras 1 Proteins (KSR1)
Did you look for something else?