Kruppel-Like Factor 2 (Lung) Proteins (KLF2)

Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. Additionally we are shipping KLF2 Antibodies (111) and KLF2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLF2 10365 Q9Y5W3
KLF2 16598 Q60843
KLF2 306330 Q9ET58
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Top KLF2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,955.33
Details

KLF2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Kruppel-Like Factor 2 (Lung) (KLF2) Interaction Partners

Human Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

  1. Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis.

  2. The findings point to KLF2 as a new gene involved in heritable pulmonary arterial hypertension.

  3. we provide evidence that the tumor-suppressive microRNA miR (show MLXIP Proteins)-1825 controls KLF2 expression. Reporter gene analyses revealed that both microRNAs directly targeted the 3'-untranslated region of KLF2 messenger RNA. These data demonstrated that miR (show MLXIP Proteins)-1825 expression in serum of human glioma was associated with tumorigenesis and miR (show MLXIP Proteins)-1825 may be used as a biomarker for identification of the pathological grade of glioma.

  4. Long noncoding RNA XIST acts as an oncogene (show RAB1A Proteins) in non-small cell lung cancer by epigenetically repressing KLF2 expression.

  5. lysine-specific demethylase (show MBD2 Proteins)-1 is an important oncogene (show RAB1A Proteins) in gastric cancer, and lysine-specific demethylase (show MBD2 Proteins)-1-mediated epigenetic repression of KLF2 plays a critical role in gastric cancer development and progression.

  6. KLF2 is shown to be downregulated in pancreatic ductal adenocarcinoma (PDAC) clinical samples and overexpression of KLF2 inhibits the growth, migration, and metastasis of PDAC cancer cells.

  7. KLF2 expression was decreased in gastric cancer and negatively correlated with lymphatic metastasis. KLF2 overexpression inhibited cell proliferation and invasive potential and downregulated the protein expression of PCNA (show PCNA Proteins), Bcl-2 (show BCL2 Proteins) and MMP-9 (show MMP9 Proteins) in GC cells. KLF2 overexpression reduced xenograft tumor growth.

  8. our data highlight an important role for KLF2/c-myc (show MYC Proteins) pathway in HCC (show FAM126A Proteins) development and progression.

  9. Authors show that KLF2 induces the expression of CRABP2 (show CRABP2 Proteins) and RARgamma and inhibits the expression FABP5 (show FABP5 Proteins) and PPARbeta (show PPARD Proteins)/delta thereby shifting RA signaling from the pro-carcinogenic FABP5 (show FABP5 Proteins)/PPARbeta (show PPARD Proteins)/delta to the growth-suppressing CRABP2 (show CRABP2 Proteins)/RAR (show RARA Proteins) path.

  10. MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of Ang2.

Pig (Porcine) Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

  1. miR (show MYLIP Proteins)-92a coregulates KLF4 (show KLF4 Proteins) and KLF2 expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.

Mouse (Murine) Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

  1. Mouse embryos deficient in Orai1 (show TMEM132A Proteins), Klf2, or Klf4 (show KLF4 Proteins) showed a significantly reduced lymphatic density and impaired lymphatic development.

  2. this study shows that KLF2 governs the degree of dendritic cells activation and hence the intensity of proatherogenic T cell responses

  3. Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis.

  4. A deficiency of KLF2 increased the expression of Notch ligand (show JAG2 Proteins) Jagged2 (show JAG2 Proteins) via hypoxia-inducible factor 1alpha (HIF-1alpha (show HIF1A Proteins)), which led to Th2 amplification.

  5. our data demonstrate a protective role of KLF2 against glomerular endothelial cell injury and progression of chronic kidney disease in the model of compensatory renal hypertrophy

  6. Under steady-state conditions, KLF2-deficient NK cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due to IL-15 (show IL15 Proteins) starvation.

  7. KLF2 knockdown markedly reduced expression of miR (show MLXIP Proteins)-155 in macrophages and macrophage activation.

  8. study therefore establishes the pivotal role of Klf2 and Tfcp2l1 (show TFCP2L1 Proteins) in mediating ESC self-renewal promoted by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  9. endothelial-specific loss of Mekk3 (show MAP3K3 Proteins), Klf2 or Klf4 (show KLF4 Proteins) markedly prevents cerebral cavernous malformation lesion formation, reverses the increase in Rho activity, and rescues lethality

  10. knockdown of Klf2 expression in endothelial cells induced more endothelial cell injury in early diabetic nephropathy

Xenopus laevis Kruppel-Like Factor 2 (Lung) (KLF2) interaction partners

  1. KLF2 and ERG (show ERG Proteins) associate in a physical complex and the two proteins synergistically activate transcription of Flk1 (show KDR Proteins).

KLF2 Protein Profile

Protein Summary

Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1\; MIM 601974) and the selectin CD62L (SELL\; MIM 153240) (summary by Weinreich et al., 2009

Gene names and symbols associated with KLF2

  • Kruppel-like factor 2 (lung) (klf2)
  • Krueppel-like factor 2 (klf2)
  • Kruppel-like factor 2 (lung) (KLF2)
  • Kruppel-like factor 2 (lung) (Klf2)
  • klf2 protein
  • Lklf protein
  • MGC52512 protein

Protein level used designations for KLF2

Kruppel-like factor 2 (lung) , Krueppel-like factor 2 , Kruppel-like factor LKLF , lung Kruppel-like zinc finger transcription factor , lung krueppel-like factor , lung Kruppel-like factor

GENE ID SPECIES
549518 Xenopus (Silurana) tropicalis
100286404 Salmo salar
100586551 Nomascus leucogenys
10365 Homo sapiens
100174959 Sus scrofa
16598 Mus musculus
306330 Rattus norvegicus
420148 Gallus gallus
380122 Xenopus laevis
520939 Bos taurus
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