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Kv Channel Interacting Protein 2 Proteins (KCNIP2)

KCNIP2 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Additionally we are shipping KCNIP2 Antibodies (105) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNIP2 619380  
KCNIP2 30819 Q9NS61
KCNIP2 80906 Q9JJ69
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Top KCNIP2 Proteins at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,704.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KCNIP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,
Mouse (Murine)

More Proteins for Kv Channel Interacting Protein 2 (KCNIP2) Interaction Partners

Human Kv Channel Interacting Protein 2 (KCNIP2) interaction partners

  1. A novel KCNQ1 (show KCNQ1 Proteins)-G229D mutation identified in a juvenile-onset AF patient altered the IKs activity and kinetics, thereby increasing the arrhythmogenicity to AF.

  2. mutations cause a gainoffunction of KV4.3 (show KCND3 Proteins)/KChIP2encoded channels by increasing membrane protein expression and slowing channel inactivation.

  3. The "structurally minimal" isoform KChIP2d modulates recovery of K(v)4.3 (show KCND3 Proteins) N-terminal deletion mutant Delta2-39.

  4. KChIP2 differentially regulates total and cell surface Kv4.2 (show KCND2 Proteins) protein expression and Kv4 (show KCNC1 Proteins) current densities.

  5. The I(to) activator NS5806 modified Kv4.3 (show KCND3 Proteins)/KChIP2 gating in several ways that inhibit current.

  6. The cytoplasmic accessory subunit KChIP2 also assembles with Kv4.2 (show KCND2 Proteins) to increase peak current, shift V1/2 ~5mV, slow time to peak ~10%, slow inactivation ~100%, and speed recovery from inactivation ~250% without overshoot.

  7. N-linked glycosylation of DPP10 plays an important role in modulating Kv4.3 (show KCND3 Proteins) channel/KCHIP2 complex activities.

  8. Down-regulated atrial KChIP2 and Kv4.3 (show KCND3 Proteins) mRNA expressions in rheumatic heart disease patients with chronic atrial fibrillation might be one of the molecular bases responsible for the down-regulation of the I(to) current density of AF.

  9. Regulation of Kv4.3 (show KCND3 Proteins) current by KChIP2 splice variants

  10. Analysis with chimeric proteins between KChIP2 and NCS-1 (show NCS1 Proteins) reveals that the three regions of KChIP2 are necessary and sufficient for its effective binding to Kv4.3 (show KCND3 Proteins) protein

Mouse (Murine) Kv Channel Interacting Protein 2 (KCNIP2) interaction partners

  1. The downregulation of repolarizing currents in heart failure is accentuated in KChIP2(-/-) mice.

  2. Real-time RT-PCR and Western blotting revealed that Kv4.2 (show KCND2 Proteins) expression was downregulated in both BSO-treated groups, whereas KChIP2 expression was downregulated only in the H/M-Sod2 (show SOD2 Proteins)(+/-)+BSO group (P<0.05).

  3. Development of heart failure is independent of K+ channel (show KCNC4 Proteins)-interacting protein 2 expression.

  4. KChIP2 is essential for physiologic somatodendritic potassium current modulation and homeostatic stability.

  5. The combined down-regulation of Kv4.2 (show KCND2 Proteins), Kv1.5 (show KCNA5 Proteins) and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model.

  6. KChIP2 differentially regulates total and cell surface Kv4.2 (show KCND2 Proteins) protein expression and Kv4 (show KCNC1 Proteins) current densities.

  7. KChIP2 has a role in mediating regulation of CaV1.2 (show CACNA1C Proteins)

  8. KChIP2 transcripts were highly expressed in layer IV of the cerebral cortex and in striatum and hippocampus, but expressed at low levels in cerebellum.

  9. KChIP2 contributes to the formation of functional mouse ventricular Kv1.5 (show KCNA5 Proteins) channels

  10. KChIP2 modulates multiple K(V) and Na(V) currents, these results suggest that KChIP2 is a multimodal regulator of cardiac ionic currents.

KCNIP2 Protein Profile

Protein Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.

Gene names and symbols associated with KCNIP2

  • Kv channel interacting protein 2 (KCNIP2)
  • A-type potassium channel modulatory protein 2 (Kchip2)
  • Kv channel interacting protein 2 (kcnip2)
  • Kv channel-interacting protein 2 (Kcnip2)
  • KChIP2 protein
  • KCNIP2 protein

Protein level used designations for KCNIP2

Kv channel interacting protein 2 , A-type potassium channel modulatory protein 2 , Kv channel-interacting protein 2 , cardiac voltage-gated potassium channel modulatory subunit , potassium channel-interacting protein 2 , Kv channel-interacting protein , potassium channel auxiliary subunit KCHIP2

GENE ID SPECIES
745263 Pan troglodytes
100060206 Equus caballus
619380 Rattus norvegicus
100009019 Oryctolagus cuniculus
779161 Xenopus laevis
374098 Gallus gallus
30819 Homo sapiens
403598 Canis lupus familiaris
540895 Bos taurus
56817 Rattus norvegicus
80906 Mus musculus
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