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L(3)mbt-Like 1 (Drosophila) Proteins (L3MBTL1)

L3MBTL1 represents a polycomb group gene. Additionally we are shipping L3MBTL1 Antibodies (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
L3MBTL1 241764 A2A5N8
L3MBTL1 26013 Q9Y468
Rat L3MBTL1 L3MBTL1 311613 D3ZWK4
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Top L3MBTL1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

L3MBTL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for L(3)mbt-Like 1 (Drosophila) (L3MBTL1) Interaction Partners

Mouse (Murine) L(3)mbt-Like 1 (Drosophila) (L3MBTL1) interaction partners

  1. L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms.

  2. generation and analysis of mice after disruption of L3MBTL1

Human L(3)mbt-Like 1 (Drosophila) (L3MBTL1) interaction partners

  1. The polycomb group protein L3MBTL1 represses a SMAD5 (show SMAD5 Proteins)-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  2. High expression of L3MBTL1 was associated with low grade and hormone receptor (show NR4A1 Proteins)-positive tumors, as well as low risk of disease recurrence and breast cancer death.

  3. depletion of L3MBTL1 does not affect hESC self-renewal, rather it enhances differentiation toward extra-embryonic trophoblast tissues

  4. Data suggest that the loss of L3MBTL1 contributes to the development of 20q(-) hematopoietic malignancies by inducing replicative stress, DNA damage, and genomic instability.

  5. SET8 (show SETD8 Proteins)-mediated methylation of p53 (show TP53 Proteins) at Lys (show LYZ Proteins)-382 promotes the interaction between L3MBTL1 and p53 (show TP53 Proteins) in cells.

  6. haploinsufficiency of L3MBTL1 contributes to some (20q-) myeloproliferative neoplasms, especially polycythemia vera (show IGF2BP3 Proteins), by promoting erythroid differentiation

  7. The ability of TEL (show ETV6 Proteins) to repress TEL (show ETV6 Proteins)-responsive promoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL (show ETV6 Proteins) interacting domains, which are mapped to their respective SPM (show NPC1 Proteins)/SAM (show TTN Proteins) domains.

  8. represents a previously undescribed imprinted locus, a vertebrate Polycomb (show CBX2 Proteins) group gene shown to be regulated by this mechanism, and has implications for the pathogenesis of myeloid malignancies associated with 20q deletions

  9. L3MBTL may have a role in myeloid leukemia (show BCL11A Proteins)

  10. The MBT domain is related to protein domains that directly bind methylated histone residues and study found that L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26.

L3MBTL1 Protein Profile

Protein Summary

This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with L3MBTL1

  • l(3)mbt-like (Drosophila) (L3mbtl1)
  • l(3)mbt-like 1 (Drosophila) (L3MBTL1)
  • l(3)mbt-like 1 (Drosophila) (L3mbtl1)
  • C630004G01 protein
  • dJ138B7.3 protein
  • H-L(3)MBT protein
  • L3MBTL protein
  • mKIAA0681 protein
  • RGD1307316 protein
  • ZC2HC3 protein

Protein level used designations for L3MBTL1

H-l(3)mbt protein , L(3)mbt protein homolog , lethal(3)malignant brain tumor-like protein 1 , l(3)mbt protein homolog , lethal (3) malignant brain tumor l(3) , L(3)malignant brain tumor-like protein

GENE ID SPECIES
241764 Mus musculus
26013 Homo sapiens
529298 Bos taurus
419115 Gallus gallus
311613 Rattus norvegicus
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