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May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. Additionally we are shipping LAG1 Homolog, Ceramide Synthase 5 Antibodies (66) and many more products for this protein.
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Studied the role of ceramide synthase 5 (LASS5 or CERS5) gene in atherosclerosis. Downregulation of LASS5 by siRNA was found to attenuate ceramide production and increase expression of some AMPK (show PRKAA1 Proteins) target genes in HUVEC. Found that LASS5 was involved in negative regulation of atherosclerosis-related genes, such as AMPK (show PRKAA1 Proteins)-alpha.
mRNA level of CerS5 is higher in cancerous cell lines and decreases following the induction of apoptosis.
Overexpression of CerS5 increased apoptosis in HeLa cells.
study identifies LASS5 as a genuine dihydroceramide synthase and demonstrates that mammalian dihydroceramide synthases do not require additional subunits for their activity
accumulation of C(16)-ceramide in mitochondria formed from the protein kinase C-dependent salvage pathway results at least in part from the action of longevity-assurance homologue 5, and the generated ceramide modulates the p38 (show CRK Proteins) cascade via PP1 (show PPA1 Proteins)
Down-regulation of either acid sphingomyelinase (show SMPD1 Proteins) or LASS 5-attenuated ceramide accumulation and H/R-induced Bax (show BAX Proteins) translocation to mitochondria.
Ceramide synthase 5 is essential to maintain C16:0-ceramide pools and contributes to the development of diet-induced obesity.
Transfection of Lass5 cDNA into or pulse of Lass5 peptide onto B7-1 (show CD80 Proteins) positive RMA-S cells overcomes the requirement of the B7-1 (show CD80 Proteins)/CD28 (show CD28 Proteins) signal for T effector response.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (show CERS1 Proteins)-Cers6 (show CERS6 Proteins)) activity in macrophages is responsible for the accumulation of ceramide.
Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes.
Lag1p family members trh1 (show CERS4 Proteins) and trh4 regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids
LASS5 is the major ceramide synthase gene product involved in sphingolipid production that may also regulate phosphatidylcholine (show SGMS2 Proteins) metabolism in pulmonary epithelia
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner (By similarity).
LAG1 homolog, ceramide synthase 5
, LAG1 longevity assurance homolog 5-like
, LAG1 longevity assurance homolog 5
, TRAM homolog 4
, longevity assurance homolog 5
, translocating chain-associating membrane protein homolog 4