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anti-LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) Antibodies

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. Additionally we are shipping LMO2 Proteins (11) and LMO2 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LMO2 16909 P25801
LMO2 362176  
LMO2 4005 P25791
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Top anti-LMO2 Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB LMO2 Antibody (N-term) (ABIN658023) western blot analysis in NCI-H460 ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p) Flow cytometric analysis of rabbit anti-LMO2 (SP51) antibody in RAMOS ... 7 mL Log in to see 2 to 3 Days
$377.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-LMO2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1... WB Suggested Anti-LMO2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Flow cytometric analysis of rabbit anti-LMO2 (SP51) antibody in RAMOS ... 1 mL Log in to see 2 to 3 Days
$659.00
Details
Human Mouse Un-conjugated FACS, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green... Figure 2: 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated WB LMO2 monoclonal antibody (M02), clone 2B3. Western Blot analysis of LM... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 21 to 31 Days
$237.00
Details
Human Mouse Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
$280.00
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details

LMO2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , ,

Rat (Rattus) , ,

Human , , , ,
, ,

Top referenced anti-LMO2 Antibodies

  1. Human Monoclonal LMO2 Primary Antibody for WB - ABIN394113 : Younes, Beck, Lossos, Levy, Warnke, Natkunam: Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components. in The American journal of surgical pathology 2010 (PubMed)
    Show all 5 references for ABIN394113

  2. Human Polyclonal LMO2 Primary Antibody for IHC (p), WB - ABIN658023 : Oram, Thoms, Pridans, Janes, Kinston, Anand, Landry, Lock, Jayaraman, Huntly, Pimanda, Göttgens: A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients. in Oncogene 2010 (PubMed)
    Show all 4 references for ABIN658023

  3. Human Monoclonal LMO2 Primary Antibody for FACS, IHC (p) - ABIN1687893 : Xie, Bulbul, Ji, Inouye, Groshen, Tulpule, OMalley, Wang, Siddiqi et al.: p53 expression is a strong marker of inferior survival in de novo diffuse large B-cell lymphoma and may have enhanced negative effect with MYC coexpression: a single institutional clinicopathologic ... in American journal of clinical pathology 2014 (PubMed)
    Show all 2 references for ABIN1687893

  4. Human Monoclonal LMO2 Primary Antibody for FACS, ELISA - ABIN1098128 : Cubedo, Maurin, Jiang, Lossos, Wright: PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL. in The FEBS journal 2011 (PubMed)
    Show all 2 references for ABIN1098128

  5. Human Monoclonal LMO2 Primary Antibody for IHC (p) - ABIN1688299 : Agostinelli, Paterson, Gupta, Righi, Sandri, Piccaluga, Bacci, Sabattini, Pileri, Marafioti: Detection of LIM domain only 2 (LMO2) in normal human tissues and haematopoietic and non-haematopoietic tumours using a newly developed rabbit monoclonal antibody. in Histopathology 2012 (PubMed)
    Show all 2 references for ABIN1688299

  6. Chicken Polyclonal LMO2 Primary Antibody for WB - ABIN2792668 : Yuan, Sun, Yang, Du, Zhai, Wang, Zhang, Zhu: Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors. in Leukemia 2008 (PubMed)

More Antibodies against LMO2 Interaction Partners

Mouse (Murine) LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) interaction partners

  1. Hhex (show HHEX Antibodies) regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.

  2. HHEX (show HHEX Antibodies) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.

  3. GATA2 (show GATA2 Antibodies) and Lmo2 cooperatively regulate VEGF (show VEGFA Antibodies)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Antibodies).

  4. a regulatory hierarchy of HOX (show MSH2 Antibodies) control of LMO2 in normal development

  5. Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.

  6. A model in which the distal control region functions through a chromatin looping mechanism to contact and enhance Lmo2 transcription specifically in erythroid cells.

  7. Studied the solution structure of Lmo2(LIM2 (show LHX2 Antibodies)) /Ldb1 (show LDB1 Antibodies)(LID) complex. Results show modular binding of tandem LIM (show PDLIM5 Antibodies) domains in Lmo2 to tandem linear motifs in Ldb1 (show LDB1 Antibodies) is accompanied by several disorder-to-order transitions/ conformational changes in both proteins.

  8. Studies demonstrate that Etv2 (show ETV2 Antibodies) is expressed during and required for yolk sac (show ADCY10 Antibodies) hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2 (show ETV2 Antibodies).

  9. This result raises the possibility that oncogenic Lck (show LCK Antibodies) may activate Lmo2 promoter through direct interaction.

  10. Data show that thymic expression of the Tal1 (show TAL1 Antibodies) and Lmo2 oncogenes results in rapid development of T-ALL, and similar to T-ALL patients, more than half the leukemic mice develop spontaneous mutations in Notch1 (show NOTCH1 Antibodies).

Human LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) interaction partners

  1. Alanine scanning mutagenesis of the LIM (show PDLIM5 Antibodies) interaction domain of LDB1 (show LDB1 Antibodies) revealed a discrete motif, R(320)LITR, required for LMO2 binding.

  2. LMO2 expression was elevated in GBM tissues and inversely correlated with prognosis of GBM patients. Taken together, our findings describe novel dual roles of LMO2 to induce tumorigenesis and angiogenesis.

  3. Diagnostic Utility of the Germinal Center-associated Markers GCET1 (show SERPINA9 Antibodies), HGAL (show GCET2 Antibodies), and LMO2 in Hematolymphoid Neoplasms.

  4. Data show that the Lim domain only 2 (LMO2) regulatory element (element-25) region consists of transcription factor GATA2 (show GATA2 Antibodies)-binding myeloid ennhancer and RUNX protein-binding T-cell repressor.

  5. Cryptic chromosomal rearrangements in the LMO2 gene were associated with T-cell acute lymphoblastic leukemia.

  6. results suggest that E47 (show TCF3 Antibodies) has diverse effects in T-ALL but that functional deficiency of E47 (show TCF3 Antibodies) is not a universal feature of Lmo2-induced T-ALL.

  7. HHEX (show HHEX Antibodies) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.

  8. LMO2 is expressed in a subset of acute myeloid leukaemia patients and is associated with normal karyotype, which is different from T lymphoblastic lymphoma/leukaemia, where specific translocation (11p13) mediates protein expression.

  9. GATA2 (show GATA2 Antibodies) and Lmo2 cooperatively regulate VEGF (show VEGFA Antibodies)-induced angiogenesis and lymphangiogenesis via NRP2 (show NELL2 Antibodies).

  10. In t(8;21) leukemia cells, LMO2 functions as a component of the stable AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.

Zebrafish LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) interaction partners

  1. a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure

  2. in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1 (show TAL1 Antibodies)-Lmo2-induced haemangioblasts differentiate into endothelial cells

  3. Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated.

  4. Scl (show TAL1 Antibodies)/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other

LMO2 Antigen Profile

Protein Summary

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with LMO2

  • Rhombotin-2 (rbtn2) antibody
  • LIM domain only 2 (rhombotin-like 1) (LOC100232598) antibody
  • LIM domain only 2 (Lmo2) antibody
  • LIM domain only 2 (rhombotin-like 1) (LMO2) antibody
  • LIM domain only 2 (rhombotin-like 1) (lmo2) antibody
  • LMO-2 antibody
  • lmo2-A antibody
  • Rbtn-2 antibody
  • RBTN2 antibody
  • RBTNL1 antibody
  • Rhom-2 antibody
  • RHOM2 antibody
  • rhombotin-2 antibody
  • TTG2 antibody
  • wu:fc83a08 antibody
  • xlmo2 antibody
  • zgc:111930 antibody

Protein level used designations for LMO2

Rhombotin-2 , LIM domain only 2 (rhombotin-like 1) , LIM domain only protein 2 , LIM only 2 , LMO-2 , T-cell translocation protein 2 , cysteine-rich protein TTG-2 , rhombotin-2 , T-cell translocation gene 2 , rhombotin 2 , rhombotin-like 1 , LIM domain only-2 , ttg2 , zlmo2 , xLMO-2

GENE ID SPECIES
100194984 Salmo salar
100232598 Taeniopygia guttata
100301679 Oncorhynchus mykiss
16909 Mus musculus
362176 Rattus norvegicus
4005 Homo sapiens
30332 Danio rerio
614876 Bos taurus
394388 Xenopus laevis
374129 Gallus gallus
609006 Canis lupus familiaris
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