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LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. Additionally we are shipping LMO2 Proteins (11) and LMO2 Kits (3) and many more products for this protein.
Showing 10 out of 119 products:
Human Monoclonal LMO2 Primary Antibody for WB - ABIN394413
Younes, Beck, Lossos, Levy, Warnke, Natkunam: Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components. in The American journal of surgical pathology 2010
Show all 5 references for ABIN394413
Human Polyclonal LMO2 Primary Antibody for IHC (p), WB - ABIN658023
Oram, Thoms, Pridans, Janes, Kinston, Anand, Landry, Lock, Jayaraman, Huntly, Pimanda, Göttgens: A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients. in Oncogene 2010
Show all 4 references for ABIN658023
Human Monoclonal LMO2 Primary Antibody for FACS, IHC (p) - ABIN1687893
Xie, Bulbul, Ji, Inouye, Groshen, Tulpule, OMalley, Wang, Siddiqi et al.: p53 expression is a strong marker of inferior survival in de novo diffuse large B-cell lymphoma and may have enhanced negative effect with MYC coexpression: a single institutional clinicopathologic ... in American journal of clinical pathology 2014
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Human Monoclonal LMO2 Primary Antibody for FACS, ELISA - ABIN1098128
Cubedo, Maurin, Jiang, Lossos, Wright: PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL. in The FEBS journal 2011
Show all 2 references for ABIN1098128
Human Monoclonal LMO2 Primary Antibody for IHC (p) - ABIN1688299
Agostinelli, Paterson, Gupta, Righi, Sandri, Piccaluga, Bacci, Sabattini, Pileri, Marafioti: Detection of LIM domain only 2 (LMO2) in normal human tissues and haematopoietic and non-haematopoietic tumours using a newly developed rabbit monoclonal antibody. in Histopathology 2012
Show all 2 references for ABIN1688299
Human Monoclonal LMO2 Primary Antibody for ChIP, ICC - ABIN259552
Natkunam, Zhao, Mason, Chen, Taidi, Jones, Hammer, Hamilton Dutoit, Lossos, Levy: The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas. in Blood 2007
Chicken Polyclonal LMO2 Primary Antibody for WB - ABIN2792668
Yuan, Sun, Yang, Du, Zhai, Wang, Zhang, Zhu: Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors. in Leukemia 2008
Hhex (show HHEX Antibodies) regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
HHEX (show HHEX Antibodies) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.
GATA2 (show GATA2 Antibodies) and Lmo2 cooperatively regulate VEGF (show VEGFA Antibodies)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Antibodies).
a regulatory hierarchy of HOX (show MSH2 Antibodies) control of LMO2 in normal development
Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.
A model in which the distal control region functions through a chromatin looping mechanism to contact and enhance Lmo2 transcription specifically in erythroid cells.
Studied the solution structure of Lmo2(LIM2 (show LHX2 Antibodies)) /Ldb1 (show LDB1 Antibodies)(LID) complex. Results show modular binding of tandem LIM (show PDLIM5 Antibodies) domains in Lmo2 to tandem linear motifs in Ldb1 (show LDB1 Antibodies) is accompanied by several disorder-to-order transitions/ conformational changes in both proteins.
Studies demonstrate that Etv2 (show ETV2 Antibodies) is expressed during and required for yolk sac (show ADCY10 Antibodies) hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2 (show ETV2 Antibodies).
This result raises the possibility that oncogenic Lck (show LCK Antibodies) may activate Lmo2 promoter through direct interaction.
Data show that thymic expression of the Tal1 (show TAL1 Antibodies) and Lmo2 oncogenes results in rapid development of T-ALL, and similar to T-ALL patients, more than half the leukemic mice develop spontaneous mutations in Notch1 (show NOTCH1 Antibodies).
LMO2 was associated with increased levels of cytosolic p27(Kip1 (show CDKN1B Antibodies)) protein.
that suppression of MIR223 expression, as compared with controls, is associated with lack of differentiation and adverse cytogenetic profile, but unrelated with LMO2 protein expression or overall survival.
Alanine scanning mutagenesis of the LIM (show PDLIM5 Antibodies) interaction domain of LDB1 (show LDB1 Antibodies) revealed a discrete motif, R(320)LITR, required for LMO2 binding.
LMO2 expression was elevated in GBM tissues and inversely correlated with prognosis of GBM patients. Taken together, our findings describe novel dual roles of LMO2 to induce tumorigenesis and angiogenesis.
Diagnostic Utility of the Germinal Center-associated Markers GCET1 (show SERPINA9 Antibodies), HGAL (show GCET2 Antibodies), and LMO2 in Hematolymphoid Neoplasms.
Data show that the Lim domain only 2 (LMO2) regulatory element (element-25) region consists of transcription factor GATA2 (show GATA2 Antibodies)-binding myeloid ennhancer and RUNX protein-binding T-cell repressor.
Cryptic chromosomal rearrangements in the LMO2 gene were associated with T-cell acute lymphoblastic leukemia.
results suggest that E47 (show TCF3 Antibodies) has diverse effects in T-ALL but that functional deficiency of E47 (show TCF3 Antibodies) is not a universal feature of Lmo2-induced T-ALL.
LMO2 is expressed in a subset of acute myeloid leukaemia patients and is associated with normal karyotype, which is different from T lymphoblastic lymphoma/leukaemia, where specific translocation (11p13) mediates protein expression.
a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1 (show TAL1 Antibodies)-Lmo2-induced haemangioblasts differentiate into endothelial cells
Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated.
Scl (show TAL1 Antibodies)/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
, LIM domain only 2 (rhombotin-like 1)
, LIM domain only protein 2
, LIM only 2
, T-cell translocation protein 2
, cysteine-rich protein TTG-2
, T-cell translocation gene 2
, rhombotin 2
, rhombotin-like 1
, LIM domain only-2