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LIM Homeobox 3 Proteins (LHX3)

LHX3 encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. Additionally we are shipping LHX3 Antibodies (25) and LHX3 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LHX3 8022 Q9UBR4
Rat LHX3 LHX3 170671  
LHX3 16871 P50481
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Top LHX3 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,091.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,091.00
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,102.00
Details

LHX3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for LIM Homeobox 3 (LHX3) Interaction Partners

Human LIM Homeobox 3 (LHX3) interaction partners

  1. investigated the specific mutations in PROP1 (show PROP1 Proteins), POU1F1 (show POU1F1 Proteins), LHX3, and HESX1 (show HESX1 Proteins) genes in patients with combined pituitary hormone (show CGA Proteins) deficiency (CPHD) in Turkey

  2. LHX3 is upregulated in high-grade oligodendroglioma.

  3. The downstream enhancer region of LHX3 in regulating gene expression at the cellular level during development, is reported.

  4. Data suggest that low serum FSH (show BRD2 Proteins) (follicle stimulating hormone) levels in men with SNP in promoter region of FSHB (FSH beta (show FSHB Proteins) subunit (show POLG Proteins); -211G/T) result from reduced LHX3 binding to FSHB (show FSHB Proteins) promoter and down-regulation of FSHB (show FSHB Proteins) transcription in gonadotrophs.

  5. The present study was unable to confirm a significant association of all of the three SNPs, rs12338076 in LHX3-QSOX2, and rs1457595 and rs17032362 in IGF1 (show IGF1 Proteins), with adult height in our study population.

  6. descriprion of pediatric patients with combined pituitary hormone (show CGA Proteins) deficiency with a novel mutation in LHX3; the T194R mutation affects a critical residue in the LHX3 protein; study extends understanding of phenotypic features, molecular mechanism and developmental course associated with mutations in the LHX3 gene

  7. This study of the first nonconsanguineous patient with LHX3 mutations demonstrates the pleiotropic roles of LHX3 during development and its full involvement in the complex disease phenotype of syndromic combined pituitary hormone (show CGA Proteins) deficiency.

  8. This study establishes ISL1 (show ISL1 Proteins) as a novel transcriptional regulator of LHX3 and describes a potential mechanism for regulation by PITX1 (show PITX1 Proteins).

  9. LHX3 mutations are a rare cause of hypopituitarism. We report on a patient with a novel LHX3 mutation in exon 2 with the phenotype of combined pituitary hormone (show CGA Proteins) deficiency with short neck and sensorineural hearing impairment. [review]

  10. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 (show IGF1 Proteins) as adult height loci.

Zebrafish LIM Homeobox 3 (LHX3) interaction partners

  1. Lhx3 and Lhx4 (show LHX4 Proteins) have roles in suppressing Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons

Pig (Porcine) LIM Homeobox 3 (LHX3) interaction partners

  1. LHX3 LIM homeodomain (show LHX2 Proteins) transcription factor is involved in activation of the FSH beta (show FSHB Proteins)-subunit (show POLG Proteins) gene in the pituitary gonadotrope cell.

Cow (Bovine) LIM Homeobox 3 (LHX3) interaction partners

  1. Association analysis indicated that the some SNPs studied are associated with the body weight at 6, 12 and 18months of age in Nanyang cattle (P<0.01 or P<0.05), providing evidence that some SNPs in LHX3 gene may be associated with body weight at certain ages.

  2. The isolation and characterization of three polymorphisms of LHX3 are reported.

Mouse (Murine) LIM Homeobox 3 (LHX3) interaction partners

  1. All E1 sequences from lamprey to mouse responded equally well to Phox2a (show PHOX2A Proteins) and the Isl1 (show ISL1 Proteins)-Lhx3 complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals

  2. We discovered that expression of Cdkn1a (show CDKN1A Proteins) is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 (show LHX4 Proteins) mutants.

  3. Lhx3-LIM (show PDLIM5 Proteins) domains play critical roles in transactivation of the Isl1 (show ISL1 Proteins)-Lhx3 complex by not only directing the assembly of the Isl1 (show ISL1 Proteins)-Lhx3 complex but also recruiting coactivators to the complex.

  4. This treatment leads to activation of Lhx3 gene expression.

  5. LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP (show ANP32A Proteins) and TAF (show TAF8 Proteins)-1beta to modulate pituitary gene regulation.

  6. The results of this study suggested that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.

  7. Data characterized an intramolecular interaction between the LIM (show PDLIM5 Proteins) domains and LIM homeobox 3 (Lhx3)-binding domain in Isl1 (show ISL1 Proteins).

  8. Solution structure of the LIM-homeodomain (show LHX2 Proteins) transcription factor complex Lhx3/Ldb1 (show LDB1 Proteins) and the effects of a pituitary mutation on key Lhx3 interactions.

  9. Isl1 (show ISL1 Proteins)-Lhx3, a LIM (show PDLIM5 Proteins)-complex mimicking fusion, induces a signature of motor neuron transcriptome & suppresses interneuron differentiation programs. An equimolar ratio of Isl1 (show ISL1 Proteins) & Lhx3 & the LIM (show PDLIM5 Proteins) domain of Lhx3 are crucial for this.

  10. X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4 (show LHX4 Proteins).Isl2 (show ISL2 Proteins) complex exhibit many similarities with that of Lhx3.Isl1 (show ISL1 Proteins); structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.

LHX3 Protein Profile

Protein Summary

This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with LIM Homeobox 3 Proteins (LHX3)

  • lim homeobox 3 (lim3)
  • LIM homeobox 3 (LOC100224079)
  • LIM homeobox 3 (LHX3)
  • LIM homeobox 3 (Lhx3)
  • LIM homeobox 3 (lhx3)
  • LIM homeobox protein 3 (Lhx3)
  • CPHD3 protein
  • lim-3 protein
  • Lim3 protein
  • M2-LHX3 protein
  • mLim-3 protein
  • mLIM3 protein
  • P-LIM protein
  • xlim-3 protein

Protein level used designations for LIM Homeobox 3 Proteins (LHX3)

lim homeobox 3 , LIM homeobox 3 , LIM homeobox protein 3 , LIM/homeobox protein Lhx3 , LIM/homeodomain protein LHX3 , homeobox protein LIM-3 , LIM homeodomain protein 3 , LIM homeodomain 3 protein b isoform , LIM homeo box protein 3 , homeobox protein P-LIM

GENE ID SPECIES
662120 Tribolium castaneum
100224079 Taeniopygia guttata
8022 Homo sapiens
170671 Rattus norvegicus
30455 Danio rerio
397959 Xenopus laevis
373940 Gallus gallus
607584 Canis lupus familiaris
396712 Sus scrofa
539213 Bos taurus
101111265 Ovis aries
16871 Mus musculus
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