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LHX4 encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. Additionally we are shipping LHX4 Antibodies (64) and LHX4 Kits (19) and many more products for this protein.
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Lhx3 (show LHX3 Proteins) and Lhx4 have roles in suppressing Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons
The study identified 4 new LHX4 heterozygous allelic variants in patients with congenital hypopituitarism: W204X, delK242, N271S and Q346R.
A novel homozygous mutation in LHX4 associated with a lethal phenotype, implying that recessive mutations in LHX4 may be incompatible with life.
we found that LHX4 upregulated beta-catenin (show CTNNB1 Proteins) levels in human colorectal cancer cell lines
Data indicate that HESX1 (show HESX1 Proteins), LHX4 and SOX3 (show SOX3 Proteins) polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).
This study is the first to describe, a gradual loss of ACTH (show POMC Proteins) in a patient carrying an LHX4 mutation.
Variably penetrant pituitary insufficiency, including this severe and atypical presentation, can be correlated with LHX4 insufficiency and highlights the role of LHX4 for pituitary development.
data indicate that LHX4 may act as a potential tumor suppressor in hepatocarcinogenesis, suggesting that targeting LHX4 to downregulate AFP (show AFP Proteins) might have therapeutic implications
A novel HESX1 (show HESX1 Proteins) causative mutation was found in a consanguineous family, and two LHX4 mutations were present in familial Pituitary stalk interruption syndrome.
"Heterozygous splice site mutations within LHX4 are associated with combined pituitary hormone deficiency and isolated growth hormone deficiency... small sella turcica...persistent craniopharyngeal canal...ectopic posterior pituitary... " P. 207
LHX4 expression is transient, and, at 6 weeks of development, is stronger at the caudal than at the cervical level.
some polymorphisms in LHX4 are associated with growth traits at certain ages, and may be used as candidates for marker-assisted selection and management
We discovered that expression of Cdkn1a (show CDKN1A Proteins) is expanded dorsally in the pituitary primordium of both Lhx3 (show LHX3 Proteins) and Lhx4 mutants. Lhx4 mutants exhibit reduced cyclin D1 (show CCND1 Proteins) expression and have auxiliary pouch-like structures.
X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4.Isl2 (show ISL2 Proteins) complex exhibit many similarities with that of Lhx3 (show LHX3 Proteins).Isl1 (show ISL1 Proteins); structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.
Lhx4 and Prop1 (show PROP1 Proteins) have critical, but mechanistically different roles in specification and expansion of specialized anterior pituitary cells
We conclude Sp1 (show SP1 Proteins) directly regulates Lhx4 gene expression.
Results show that Lhx3 (show LHX3 Proteins) exhibits specific spatial and temporal expression in the mouse placenta, but that absence of both LHX3 (show LHX3 Proteins) and 4 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr (show GNRHR Proteins).
Successful purification and crystallization of an engineered complex comprising the LIM (show PDLIM5 Proteins) domains of motor neuron protein Lhx4 and the Lim (show PDLIM5 Proteins) binding domain of Isl2 (islet 2 (show ISL2 Proteins) protein) are reported.
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4.
LIM homeobox 4
, LIM homeobox protein 4
, LIM/homeobox protein Lhx4
, LIM/homeobox protein Lhx4-like
, LIM homeo box protein 4