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G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Additionally we are shipping LGR4 Antibodies (79) and LGR4 Kits (14) and many more products for this protein.
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miR (show MLXIP Proteins)-218 directly targets LGR4 and modulated the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways in the LNCaP-IL-6 (show IL6 Proteins)+ cells.
LGR4 promotes tumorigenesis of prostate cancer via PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway.
These findings suggest that aberrant RSPO3 (show RSPO3 Proteins)-LGR4 signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (show KEAP1 Proteins)-deficient lung ADs (show AGPS Proteins).
the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors
our results suggest a previously unknown Stat3 (show STAT3 Proteins)-LGR4 molecular network, which may control osteosarcoma development and progression
RSPO (show RSPO1 Proteins)-LGR4 not only induces the clearance of RNF43 (show RNF43 Proteins)/ZNRF3 (show ZNRF3 Proteins) to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt (show WNT2 Proteins) signaling complex.
Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR (show AGRN Proteins) syndrome
GPR48 overexpression promotes cancer cell proliferation via activation of Wnt (show WNT2 Proteins) signaling.
Lgr4 overexpression promoted glioma cell proliferation through activation of Wnt (show WNT2 Proteins) signaling.
Upregulation of GPR48 resulted in increased phosphorylation of glycogen synthase kinase 3beta.
Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 (show RSPO1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)
results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging.
The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP Proteins)-mediated Lgr4-Wnt (show WNT2 Proteins) signaling during gonadal development.
suggests that Lgr4 might serve as an adaptive regulator between glucose and lipid metabolism in skeletal muscle and reveals a potentially new regulator for a well-established adaptive network
An important role for Lgr4 in motor coordination and cerebellar synaptic plasticity.
formation of polycystic lesions and renal fibrosis induced by Gpr48 deficiency involves the activation of Wnt (show WNT2 Proteins) signaling pathway but not the TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) pathway
The members of the R-spondin family are known as activators of Wnt (show WNT2 Proteins) signaling, and Lgr4, Lgr5 (show LGR5 Proteins), and Lgr6 (show LGR6 Proteins) have been identified as receptors for R-spondins.
Lgr4 regulates corpus luteum maturation through modulation of the WNT (show WNT2 Proteins)-mediated EGFR (show EGFR Proteins)-ERK (show EPHB2 Proteins) signaling pathway.
LGR4 plays an important role in the regulation of plasma lipid rhythms, partially through regulating the expression of microsomal triglyceride transfer protein (show MTTP Proteins); these data provide a possible link between the peripheral circadian clock and lipid metabolism
data revealed the roles of Lgr4 in early prostate development and in stem cell differentiation through regulation of the Wnt (show WNT2 Proteins), Notch (show NOTCH1 Proteins), and Sonic Hedgehog (show SHH Proteins) signaling pathways.
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008
G protein-coupled receptor 48
, leucine-rich repeat-containing G-protein coupled receptor 4
, G protein-coupled receptor GPR48
, G-protein coupled receptor 48