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LGR6 encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. Additionally we are shipping LGR6 Antibodies (72) and many more products for this protein.
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Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance.
Two of the three monoclonal antibodies recognized the large N-terminal extracellular domain of leucine rich repeat containing G protein-coupled receptor 6 (LGR6), and competitively blocked the binding of R-spondin 1 (show RSPO1 Proteins), which is known to be the ligand for LGR6.
LGR6 expression is significantly downregulated in human masticatory mucosa during wound healing
Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration.
Lgr6 marks nail (show CD244 Proteins) stem cells and is required for digit tip regeneration.
Lgr6 and Bmi1 (show BMI1 Proteins) have roles in stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis, while Lgr5 (show LGR5 Proteins) has a role in rapid cycling and maintance of sweat glands only
Lgr6 is expressed in cells at the basal area of taste buds in fungiform and circumvallate papillae. Lgr6+ cells give rise to taste bud cells in taste papillae in both anterior and posterior tongue.
The members of the R-spondin family are known as activators of Wnt (show WNT2 Proteins) signaling, and Lgr4 (show LGR4 Proteins), Lgr5 (show LGR5 Proteins), and Lgr6 have been identified as receptors for R-spondins.
Lgr5 (show LGR5 Proteins) has been identified as a marker of Wnt (show WNT2 Proteins)-regulated adult stem cell populations in the hair-follicle, intestine and stomach. A closely-related protein, Lgr6 marks adult stem cells responsible for fueling the renewal of the sebaceous gland and skin.[Review]
study concludes that Lgr6 marks the most primitive epidermal stem cell
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.
leucine-rich repeat-containing G protein-coupled receptor 6
, leucine-rich repeat-containing G-protein coupled receptor 6-like
, gonadotropin receptor
, leucine-rich repeat-containing G-protein coupled receptor 6