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The protein encoded by LRP1 is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. Additionally we are shipping LRP1 Kits (33) and LRP1 Proteins (8) and many more products for this protein.
Showing 10 out of 164 products:
Human Monoclonal LRP1 Primary Antibody for FACS, IHC (fro) - ABIN125959
Coukos, Gåfvels, Wisel, Ruelaz, Strickland, Strauss, Coutifaris: Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts. in The American journal of pathology 1994
Show all 7 references for ABIN125959
Human Monoclonal LRP1 Primary Antibody for FACS, IHC (fro) - ABIN125958
Wolf, Lopes, VandenBerg, Gonias: Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. in The American journal of pathology 1992
Show all 7 references for ABIN125958
Hamster Monoclonal LRP1 Primary Antibody for FACS, IHC (fro) - ABIN125957
Strickland, Kounnas, Argraves: LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995
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Human Polyclonal LRP1 Primary Antibody for EIA, IHC (p) - ABIN358150
Yu, Rux, Ma, Bdeir, Sachais: Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner. in Blood 2005
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Human Polyclonal LRP1 Primary Antibody for IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. in Journal of lipid research 2013
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Human Monoclonal LRP1 Primary Antibody for FACS - ABIN119414
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. in Leukemia research 1992
Show all 2 references for ABIN119414
Human Monoclonal LRP1 Primary Antibody for EIA, FACS - ABIN119413
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. in Cell and tissue research 1992
Show all 2 references for ABIN119413
Human Polyclonal LRP1 Primary Antibody for ELISA, WB - ABIN1533132
Van Leuven, Stas, Hilliker, Lorent, Umans, Serneels, Overbergh, Torrekens, Moechars, De Strooper: Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein. in Genomics 1995
Circulating soluble LRP1 concentrations were associated with the occurrence of carotid atherosclerosis in a hypercholesterolemia population.
LRP1 as a pathogenic gene for autosomal recessive Keratosis pilaris atrophicans and keratosis pilaris
Suggest role for LRP1/PARP1 (show PARP1 Antibodies) signaling in endothelial cell proliferation and retinal neovascularization induced by hypoxia.
it was suggested that a cell surface-expressed beta-galactoside binding protein, galectin-8, was involved in factor V endocytosis.
alpha1-antitrypsin internalization is a clathrin-dependent and low-density lipoprotein receptor-related protein 1-mediated endocytosis process.
LRP1, p38 MAPK (show MAPK14 Antibodies) and ERK1/2 (show MAPK1/3 Antibodies) mediate the internalization of beta-amyloid 1-42 in neurons.
conclusion, C667T polymorphism of LRP-1 is moderately but significantly associated with global and regional amyloid deposition in AD.
LRP1 variants may be associated with risk of ischaemic stroke.
Lrp1-antisense directly binds to high-mobility group box 2 (Hmgb2 (show HMGB2 Antibodies)) and inhibits the activity of Hmgb2 (show HMGB2 Antibodies) to enhance Srebp1a-dependent transcription of Lrp1.
Statistically significant associations were also found for the PS1 (show PSEN1 Antibodies) 1/2 polymorphism in both the dominant and recessive genetic models, whereas no association was found for the LRP (show RPSA Antibodies) C/T polymorphism
extracellular (alpha) chain (show FCGRT Antibodies) of LRP1 mediates TGFbeta (show TGFB1 Antibodies)-induced enhancement of Wnt5a (show WNT5A Antibodies), which limits intracellular cholesterol accumulation.
conclude that LRP1, NFkappaB, and miR (show MLXIP Antibodies)-155 function as members of a previously unidentified system that has the potential to inhibit or sustain inflammation
This study demonstrated that bexarotene rescues aging-related declines of synaptic proteins through a neural LRP1-mediated pathway presumably by increasing apoE (show APOE Antibodies) levels and lipidation.
LRP1 interacts with beta1-integrin mediating integrin internalization and thus correlates with downstream signaling of beta1-integrin such as focal adhesion dynamics.
Selective deletion of Lrp1 in the brain endothelium of C57BL/6 mice strongly reduced brain efflux of injected [125I] Abeta (show APP Antibodies)(1-42).
The LRP1/Pyk2 (show PTK2B Antibodies) axis represses SERCA2 (show ATP2A2 Antibodies) mRNA expression via HIF-1a (show HIF1A Antibodies).
Lrp1 mediates the internalization of non-phosphorylated cathepsins. Lrp1 inhibitor increased the secretion of cathepsins.
we detected the thymic expression of receptors responsible for endocytosis of gp96 (show HSP90B1 Antibodies)-chaperoned peptides (CD91) and intracellular activation of ER-stress pathways
PAI-1 (show SERPINE1 Antibodies) can promote cell migration via LRP1-dependent activation of the beta-catenin (show CTNNB1 Antibodies) and ERK1/2 (show MAPK1/3 Antibodies) MAPK (show MAPK1 Antibodies) pathway
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, low-density lipoprotein receptor-related protein 1