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Lysine (K)-Specific Demethylase 1B Proteins (KDM1B)

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009].. Additionally we are shipping KDM1B Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM1B 221656 Q8NB78
KDM1B 218214 Q8CIG3
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Top KDM1B Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Baculovirus Human GST tag KDM1B / LSD2 activity assay. Recombinant KDM1B / LSD2 activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant KDM1B / LSD2 protein gel. Recombinant KDM1B / LSD2 run on an SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$460.83
Details

KDM1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 1B (KDM1B) Interaction Partners

Human Lysine (K)-Specific Demethylase 1B (KDM1B) interaction partners

  1. These results demonstrate an important role for LSD2 in regulation of DNA methylation (show HELLS Proteins) and gene silencing in breast cancer.

  2. Histone demethylase LSD2 acts as an E3 ubiquitin ligase (show MUL1 Proteins) and inhibits cancer cell growth through promoting proteasomal degradation of OGT (show OGT Proteins).

  3. Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4.

  4. regulation of tissue factor pathway inhibitor-2 (TFPI-2 (show TFPI2 Proteins)) expression by lysine-specific demethylase 1 and 2

  5. The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase activity and the binding of FAD (show BRCA2 Proteins).

  6. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

Mouse (Murine) Lysine (K)-Specific Demethylase 1B (KDM1B) interaction partners

  1. reveal a direct role of hypoxia-inducible factor in regulating miRNA biogenesis and consequently activating the miR (show MLXIP Proteins)-215-KDM1B-mediated signaling required for glioma-initiating cells adaptation to hypoxia

  2. Data indicate that Myst4 (show KAT6B Proteins), Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.

  3. AOF1 is the second histone demethylase in the family of flavin-dependent amine oxidases and reveals a demethylase-independent repression function.

  4. oocytes from KDM1B-deficient females showed a substantial increase in H3K4 methylation and failed to set up the DNA methylation (show HELLS Proteins) marks at four out of seven imprinted genes examined

KDM1B Protein Profile

Protein Summary

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009

Gene names and symbols associated with KDM1B

  • lysine (K)-specific demethylase 1B (KDM1B)
  • lysine (K)-specific demethylase 1B (kdm1b)
  • lysine (K)-specific demethylase 1B (Kdm1b)
  • 4632428N09Rik protein
  • AI482520 protein
  • Aof1 protein
  • bA204B7.3 protein
  • C6orf193 protein
  • dJ298J15.2 protein
  • LSD2 protein

Protein level used designations for KDM1B

amine oxidase (flavin containing) domain 1 , lysine (K)-specific demethylase 1B , lysine-specific histone demethylase 1B-like , amine oxidase, flavin containing 1 , flavin-containing amine oxidase domain-containing protein 1 , lysine-specific histone demethylase 1B , lysine-specific histone demethylase 2

GENE ID SPECIES
513667 Bos taurus
577549 Strongylocentrotus purpuratus
100066240 Equus caballus
100401095 Callithrix jacchus
100443986 Pongo abelii
100481180 Ailuropoda melanoleuca
100489838 Xenopus (Silurana) tropicalis
100547778 Meleagris gallopavo
100552653 Anolis carolinensis
221656 Homo sapiens
218214 Mus musculus
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