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Lysine (K)-Specific Demethylase 5B Proteins (KDM5B)

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Additionally we are shipping KDM5B Antibodies (71) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM5B 10765 Q9UGL1
KDM5B 75605 Q80Y84
Rat KDM5B KDM5B 304809  
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Top KDM5B Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Sf-9 cells Human DYKDDDDK Tag JARID1B / KDM5B activity assay. Recombinant JARID1B / KDM5B activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JARID1B / KDM5B enzymatic assay. Demethylase activity of JARID1B / KDM5B was measured with an enzymatic assay. MALDI-TOF was used for detection. Catalytic rate: 20 turnovers/enzyme/hour. 20 μg Log in to see 1 to 2 Days
$460.83
Details

KDM5B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 5B (KDM5B) Interaction Partners

Human Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. KDM5B, a histone demethylase known to be involved in breast cancer tumorigenesis, as a target of miR (show MLXIP Proteins)-137.

  2. Data show that KDM5B is frequently up-regulated in hepatocellular carcinoma tissues and cell lines and correlated with poor prognosis. Its depletion leads to highly impaired clonogenesis and cell cycle arrest through up-regulation of p15 (show CDKN2B Proteins) and p27 (show PAK2 Proteins).

  3. the presented data suggest a mechanism through which Ikaros (show IKZF1 Proteins) and HDAC1 (show HDAC1 Proteins) regulate the epigenetic signature in leukemia: via regulation of JARID1B transcription.

  4. Characterization of a Linked Jumonji (show JARID2 Proteins) Domain of the KDM5/JARID1 Family of Histone H3 (show HIST3H3 Proteins) Lysine 4 Demethylases.

  5. The data demonstrated that protein expression of p16 and JARID1B/KDM5B is negatively correlated in invasive ductal carcinoma of the breast.

  6. provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB

  7. Our results, for the first time, portray a pivotal role of JARID1B in stimulating metastatic behaviors of hepatocellular carcinoma cells

  8. Our results collectively suggested that JARID1B expressed in lung cancer played a role in lung cancer cells proliferation and invasion, which may be partly associated with the p53 (show TP53 Proteins) expression

  9. PLU-1/JARID1B represents a candidate proliferation biomarker for HNSCC diagnosis and treatment.

  10. This study revealed hyper JARID1B expression and hypo histone H3 (show HIST3H3 Proteins) lysine 4 tri (show VANGL2 Proteins)-methylation in mantle cell lymphoma

Mouse (Murine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. data suggest Kdm5b negatively regulates neurogenesis and represses reelin (show RELN Proteins) in neural stem cells from the adult subventricular zone.

  2. These results suggest that KDM5B acts to repress type I IFN and other innate cytokines to promote an altered immune response following Respiratory syncytial virus infection that contributes to development of chronic disease.

  3. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR

  4. Deletion of Jarid1b compromises hematopoietic stem cell (HSC (show FUT1 Proteins)) self-renewal capacity; Jarid1b is a positive regulator of HSC (show FUT1 Proteins) potential.

  5. Mechanistically, JARID1B was required for GATA3 (show GATA3 Proteins) recruitment to the Foxa1 (show FOXA1 Proteins) promoter to activate Foxa1 (show FOXA1 Proteins) expression.

  6. KDM5B is a barrier to the reprogramming process as evidenced by the accelerated reprogramming of differentiated cells in the absence of Kdm5b.

  7. these studies identified Jarid1b as a negative regulator of hematopoietic stem cell (HSC (show FUT1 Proteins)) activity and Jhdmlf as a positive regulator of HSC (show FUT1 Proteins) activity.

  8. Results suggest a role for Jarid1b in Rb-mediated repression of cell cycle genes during senescence.

  9. results delineate an essential role for Jarid1b-mediated transcriptional control during embryonic stem cell differentiation

  10. The present study demonstrated a functional contribution of PLU1 overexpression with concomitant epigenetic dysregulation in cancer progression.

Pig (Porcine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. KDM5B is required for porcine embryo development through regulating the balance of bivalent H3K4me3-H3K27me3 modifications.

Cow (Bovine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. Histone demethylases KDM3A (show KDM3A Proteins), KDM4A (show KDM4A Proteins), and KDM4C (show KDM4C Proteins) were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period.

KDM5B Protein Profile

Protein Summary

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor (By similarity).

Gene names and symbols associated with KDM5B

  • lysine (K)-specific demethylase 5Ba (kdm5ba)
  • lysine (K)-specific demethylase 5Bb (kdm5bb)
  • lysine (K)-specific demethylase 5B (KDM5B)
  • lysine (K)-specific demethylase 5B (Kdm5b)
  • 2010009J12Rik protein
  • 2210016I17Rik protein
  • AW556288 protein
  • cb264 protein
  • CT31 protein
  • D1Ertd202e protein
  • id:ibd5050 protein
  • Jarid1b protein
  • jarid1ba protein
  • jarid1bb protein
  • mKIAA4034 protein
  • PLU-1 protein
  • Plu1 protein
  • PUT1 protein
  • Rb-Bp2 protein
  • RBBP2H1A protein
  • RGD1565602 protein
  • wu:fc44h11 protein
  • wu:fd15c05 protein
  • zgc:85741 protein

Protein level used designations for KDM5B

jumonji, AT rich interactive domain 1B (Rbp2 like) , jumonji, AT rich interactive domain 1Ba (Rbp2 like) , histone demethylase JARID1B-B , jumonji/ARID domain-containing protein 1B-B , lysine-specific demethylase 5B-B , putative DNA/chromatin binding motif , lysine (K)-specific demethylase 5B , Jumonji, AT rich interactive domain 1B (RBP2-like) , jumonji, AT rich interactive domain 1B , lysine-specific demethylase 5B-like , RBP2-H1 , cancer/testis antigen 31 , histone demethylase JARID1B , jumonji/ARID domain-containing protein 1B , lysine-specific demethylase 5B , retinoblastoma-binding protein 2 homolog 1 , retinoblastoma-binding protein 2, homolog 1A , putative DNA/chromatin binding motif 1

GENE ID SPECIES
327168 Danio rerio
415256 Danio rerio
457630 Pan troglodytes
100011885 Monodelphis domestica
100064707 Equus caballus
100077577 Ornithorhynchus anatinus
100356218 Oryctolagus cuniculus
100483283 Ailuropoda melanoleuca
10765 Homo sapiens
75605 Mus musculus
421168 Gallus gallus
479999 Canis lupus familiaris
100625438 Sus scrofa
540633 Bos taurus
304809 Rattus norvegicus
100723111 Cavia porcellus
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