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Lysine (K)-Specific Demethylase 6A Proteins (KDM6A)

KDM6A is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. Additionally we are shipping KDM6A Antibodies (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM6A 7403 O15550
KDM6A 22289 O70546
Rat KDM6A KDM6A 100310845  
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Top KDM6A Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus Human DYKDDDDK Tag Recombinant UTX / KDM6A protein gel. UTX / KDM6A protein was run on an SDS-PAGE gel and stained with Coomassie blue. UTX / KDM6A activity assay. Recombinant UTX / KDM6A activity measured using a demethylation assay. MALDI-TOF was used for detection. 20 μg Log in to see 1 to 2 Days
$460.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KDM6A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 6A (KDM6A) Interaction Partners

Human Lysine (K)-Specific Demethylase 6A (KDM6A) interaction partners

  1. UTX positively regulates E-cadherin (show CDH1 Proteins) expression in colon cancer cells.

  2. UTX is a prominent tumour suppressor that functions as a negative regulator of EMT (show ITK Proteins)-induced Cancer Stem Cell-like properties by epigenetically repressing epithelial-mesenchymal transition -TFs.

  3. Kabuki syndrome may be caused by mutations in one of two histone methyltransferase genes: KMT2D and KDM6A.

  4. Our results provide further support for the similar roles of KMT2D and KDM6A in the etiology of KS by using a vertebrate model organism to provide direct evidence of their roles in the development of organs and tissues affected in KS patients.

  5. Turner Syndrome subjects, who are predisposed to chronic ear infections, had reduced UTX expression in immune cells and decreased circulating CD4(+) CXCR5(+) T cell frequency.

  6. A report of novel KDM6A mutations in patients with Kabuki syndrome.

  7. The KDM6A gene is a histone demethylase specific for histone H3 (show HIST3H3 Proteins) Lysin 27 and regulates gene transcription [35]. In approximately 24% of urothelial carcinoma, KDM6A is altered.

  8. This study is the first to identify frequent BAP1 (show RNF2 Proteins) and BRCA pathway alterations in bladder cancer, show TERT (show TERT Proteins) promoter alterations are independent of other bladder cancer gene alterations, and show KDM6A loss is a driver of the bladder cancer phenotype.

  9. One girl had a novel splice-site mutation in KDM6A.

  10. Mutations in KMT2D gene were identified in 10/16 (62%) of the patients, whereas none of the patients had KDM6A mutations.

Mouse (Murine) Lysine (K)-Specific Demethylase 6A (KDM6A) interaction partners

  1. a critical role for the enzymatic activity of UTX in activating muscle-specific (show EIF3K Proteins) gene expression during myofiber regeneration and have revealed a physiological role for active H3K27 demethylation in vivo.

  2. Results propose that Utx plays important roles in osteoblast differentiation by controlling the expressions of Runx2 (show RUNX2 Proteins) and Osterix (show SP7 Proteins).

  3. Utx is required for T-cell development.

  4. Genome-wide association between Six4 (show SIX4 Proteins), MyoD (show MYOD1 Proteins), and the histone demethylase Utx during myogenesis.

  5. Mice with a T-cell-specific UTX deletion had fewer Tfh cells, reduced germinal center responses, no virus-specific IgG, inability to resolve chronic LCMV infections, and decreased expression of IL-6-receptor-alpha (show IL6R Proteins) and other Tfh cell-related genes.

  6. UTX may play a potential role in regulation of brown adipocyte gene expression

  7. Utx and Jmjd3 mutant mouse embryonic fibroblasts (MEFs) demonstrate dramatic loss of H3K27me3 from promoters of several Hox (show MSH2 Proteins) genes and transcription factors.

  8. Inhibition of histone demethylases UTX and JMJD3 inhibits HSV-1 reactivation from sensory neurons.

  9. H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

  10. JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation; by contrast, UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL

KDM6A Protein Profile

Protein Summary

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3.

Gene names and symbols associated with KDM6A

  • lysine (K)-specific demethylase 6A (KDM6A)
  • lysine (K)-specific demethylase 6A (Kdm6a)
  • bA386N14.2 protein
  • KABUK2 protein
  • RGD1565481 protein
  • Utx protein
  • Uty protein

Protein level used designations for KDM6A

lysine (K)-specific demethylase 6A , bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)) , histone demethylase UTX , lysine-specific demethylase 6A , ubiquitously transcribed tetratricopeptide repeat protein X-linked , ubiquitously-transcribed TPR gene on the X chromosome , ubiquitously-transcribed TPR protein on the X chromosome , ubiquitously transcribed tetratricopeptide repeat, X chromosome , 4lysine (K)-specific demethylase 6A , ubiquitously transcribed TPR protein on the X chromosome , ubiquitously transcribed X chromosome tetratricopeptide repeat protein , ubiquitously transcribed tetratricopeptide repeat gene, X chromosome , ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome

GENE ID SPECIES
100081798 Ornithorhynchus anatinus
100539898 Meleagris gallopavo
100592229 Nomascus leucogenys
7403 Homo sapiens
491845 Canis lupus familiaris
22289 Mus musculus
100310845 Rattus norvegicus
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