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Lysophosphatidic Acid Receptor 1 Proteins (LPAR1)

The integral membrane protein encoded by LPAR1 is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. Additionally we are shipping LPAR1 Antibodies (52) and LPAR1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LPAR1 1902 Q92633
LPAR1 14745 P61793
Rat LPAR1 LPAR1 116744 P61794
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Top LPAR1 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days

LPAR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Lysophosphatidic Acid Receptor 1 (LPAR1) Interaction Partners

Human Lysophosphatidic Acid Receptor 1 (LPAR1) interaction partners

  1. LPA (show APOA Proteins)-type agonist, via Carbonyl-oxygen/Lys39 interaction facilitates the formation of a hypothetical N-terminal cap tightly packed over the LPA1 heptahelical bundle.

  2. Data show high expression levels of LPAR2 (show LPAR2 Proteins) and LPAR1 in endometrial cancer tissue with positive correlations with FIGO stage suggesting them as potential biomarkers for endometrial cancer progression.

  3. Data suggest LPA (lysophosphatidic acid; acting via LPAR1) and endothelin activate Cdc42, concurrent with biphasic decrease in Rac1 activity, differential effects on RhoA; LPA/endothelin stim. leads to remodeling of invadosomes in melanoma cells.

  4. we show that LPAR1 is a novel susceptibility gene for human essential hypertension and that stress, such as shortage of sleep, increases the susceptibility of patients with risk allele to essential hypertension.

  5. Study presents three crystal structures of LPA1 in complex with antagonist tool compounds selected and designed through structural and stability analyses.

  6. Results indicate that lysophosphatidic acid-lysophosphatidic acid receptor 1 (LPA (show APOA Proteins)-LPA1) signaling contributes to the activation of rheumatoid arthritis fibroblast-like synoviocytes (FLSs).

  7. HB-EGF (show HBEGF Proteins) is a biomarker for LPA1 receptor activation in human breast and prostate cancers.

  8. Lysophosphatidylethanolamine utilizes LPA(1) and CD97 (show CD97 Proteins) in a breast cancer cell line.

  9. LPA1 and LPA2 (show LPAR2 Proteins) are major LPA (show APOA Proteins) receptor subtypes compared with low-expressed LPA3 (show LPAR3 Proteins) in PANC-1 tumor cells.

  10. Lysophosphatidic acid (LPA) increased hepatocellular carcinoma cells cell invasion, which was LPA-receptor dependent.

Mouse (Murine) Lysophosphatidic Acid Receptor 1 (LPAR1) interaction partners

  1. Data show that lysophosphatidic acid (LPA) induces phosphorylation of trkA (show NTRK1 Proteins) receptor (TrkA (show NTRK1 Proteins)) through lysophosphatidic acid receptor 1 (LPA1) binding to TrkA (show NTRK1 Proteins)

  2. LPA receptor has a role in bone loss in ovariectomized mice, but the favorable effect of its inhibition on bone remodeling is less general than hypothesized

  3. These findings suggest that tumor and stromal LPA receptors, in particular LPA1 and LPA5 (show LPAR5 Proteins), play different roles in invasion and the seeding of metastasis

  4. LPA1 receptor is involved in emotional behaviors and in the anatomical integrity of the corticolimbic circuit, the deregulation of which may be a susceptibility factor for anxiety disorders.

  5. These results suggest that Ile325, Tyr85, and Leu87 within LPA1 are essential for LPA1 protein properly folding in the ER.

  6. These results suggest that LPA1 receptor-mediated amplification of spinal LPA production is required for the development of paclitaxel-induced neuropathic pain.

  7. these results demonstrate that LPA1 is essential for in vitro and in vivo osteoclast activities.

  8. Ultrastructural analyses of peripheral nerves in mouse null-mutants for LPA1 showed delayed schwann cell-to-axon segregation, polyaxonal myelination by single schwann cells, and thinner myelin sheaths.

  9. This study demonstrate a correlation between gene expression and cell birthdates. Lpar1 cells are preferentially generated on E11.5 and survive preferentially after the first postnatal week compared with other subplate neurons

  10. Lysophosphatidic acid receptor 1 is necessary for development of arthritis.

Cow (Bovine) Lysophosphatidic Acid Receptor 1 (LPAR1) interaction partners

  1. Lysophosphatidic acid stimulates PGE (show LIPF Proteins)(2) production, cell viability, and intracellular calcium ion mobilization in cultured stromal endometrial cells via Ki16425-sensitive LPA1 receptors.

Zebrafish Lysophosphatidic Acid Receptor 1 (LPAR1) interaction partners

  1. the ATX-LPA-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates

  2. LPA(1) is necessary for lymphatic vessel formation during embryonic development in zebrafish.

LPAR1 Protein Profile

Protein Summary

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene

Gene names and symbols associated with LPAR1

  • lysophosphatidic acid receptor 1 (LPAR1)
  • lysophosphatidic acid receptor 1 (LOC100355169)
  • lysophosphatidic acid receptor 1 (Lpar1)
  • lysophosphatidic acid receptor 1 (lpar1)
  • 5031439C20 protein
  • AI326300 protein
  • EDG-2 protein
  • edg2 protein
  • Gpcr26 protein
  • GPR26 protein
  • Kdt2 protein
  • lpA1 protein
  • Mrec1.3 protein
  • rec.1.3 protein
  • si:dz22b13.1 protein
  • si:dz46m7.1 protein
  • vzg-1 protein
  • VZG1 protein
  • zgc:92157 protein

Protein level used designations for LPAR1

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 , lysophosphatidic acid receptor 1 , lysophosphatidic acid receptor 1-like , LPA receptor 1 , LPA-1 , lysophosphatidic acid receptor Edg-2 , ventricular zone gene 1 , G-protein coupled receptor 26 , clone 4.9 , endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2 , rec1.3 , lpa1 , zlpa1 , endothelium differentiation gene 2

427339 Gallus gallus
464655 Pan troglodytes
474800 Canis lupus familiaris
100355169 Oryctolagus cuniculus
100414340 Callithrix jacchus
100016607 Monodelphis domestica
100458931 Pongo abelii
100589911 Nomascus leucogenys
1902 Homo sapiens
14745 Mus musculus
116744 Rattus norvegicus
281136 Bos taurus
368461 Danio rerio
443346 Ovis aries
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