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LOX Proteins

(Lysyl Oxidase (LOX))
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
LOX Protein (Myc-DYKDDDDK Tag) LOX Protein (Myc-DYKDDDDK Tag) LOX Protein (Myc-DYKDDDDK Tag) (ABIN2712316)

LOX Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

LOX Protein (AA 174-417) (His tag) LOX Protein (AA 174-417) (His tag) LOX Protein (AA 174-417) (His tag) (ABIN7123817)

LOX Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

LOX Protein (AA 169-417) (His tag) LOX Protein (AA 169-417) (His tag) LOX Protein (AA 169-417) (His tag) (ABIN3083215)

Crystallography grade LOX Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

LOX Proteins by Grade

Find LOX Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

LOX Proteins by Origin

Find LOX Proteins for a variety of species such as anti-Human LOX, anti-Mouse LOX, anti-Chicken LOX. The species listed below are among those available. Click on a link to go to the corresponding products.

LOX Proteins by Source

Here you will find LOX Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

LOX Proteins by Protein Type

Here you can find LOX Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

LOX Proteins by Application

Find LOX Proteins validated for a specific application such as ELISA, WB, SDS, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

LOX Proteins by Biological Activity

Find LOX Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular LOX Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (12)
  • (1)
Cat. No. ABIN2712316
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123817
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3083215
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133564
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413259
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396547
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424992
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396550
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN6239913
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3010561
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2725073
Quantity 20 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
  • (1)
Cat. No. ABIN1476047
Quantity 1 mg
Datasheet Datasheet
Reactivity Chicken
Source Yeast
Validations
Cat. No. ABIN1458763
Quantity 1 mg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1459811
Quantity 1 mg
Datasheet Datasheet
Reactivity Pig
Source Yeast
Validations
Cat. No. ABIN1472498
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our LOX Proteins

Pilecki, Holm, Schlosser, Moeller, Wohl, Zuk, Heumüller, Wallis, Moestrup, Sengle, Holmskov, Sorensen: "Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation." in: The Journal of biological chemistry, Vol. 291, Issue 3, pp. 1103-14, (2016) (PubMed).

Kondala, Puri, Banka, Sachdeva, Sakhuja: "Short-term prognosis of potential celiac disease in Indian patients." in: United European gastroenterology journal, Vol. 4, Issue 2, pp. 275-80, (2016) (PubMed).

Tsukasaki, Hamada, Okamoto, Nagashima, Terashima, Komatsu, Win, Okamura, Nitta, Yasuda, Penninger, Takayanagi: "LOX Fails to Substitute for RANKL in Osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 32, Issue 3, pp. 434-439, (2016) (PubMed).

Cox, Rumney, Schoof, Perryman, Høye, Agrawal, Bird, Latif, Forrest, Evans, Huggins, Lang, Linding, Gartland, Erler: "The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase." in: Nature, Vol. 522, Issue 7554, pp. 106-10, (2015) (PubMed).

Miller, Morton, Pinese, Saturno, Jamieson, McGhee, Timpson, Leach, McGarry, Shanks, Bailey, Chang, Oien, Karim, Au, Steele, Carter, McKay, Anderson, Evans, Marais, Springer, Biankin, Erler, Sansom: "Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy." in: EMBO molecular medicine, Vol. 7, Issue 8, pp. 1063-76, (2015) (PubMed).

Richter, Dayaram, Gilmartin, Ganji, Pemmasani, Van Der Key, Shohet, Donehower, Kumar: "WIP1 phosphatase as a potential therapeutic target in neuroblastoma." in: PLoS ONE, Vol. 10, Issue 2, pp. e0115635, (2015) (PubMed).

Zhao, Sagare, Ma, Halliday, Kong, Kisler, Winkler, Ramanathan, Kanekiyo, Bu, Owens, Rege, Si, Ahuja, Zhu, Miller, Schneider, Maeda, Maeda, Sugawara, Ichida, Zlokovic: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).

Arnold, Kent, Hogarth, Schlatt, Prasad, Haenisch, Walsh, Muller, Griswold, Amory, Isoherranen: "Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations." in: Journal of lipid research, Vol. 56, Issue 2, pp. 342-57, (2015) (PubMed).

Wilson, Bradley, Shaw, Wagenmakers: "Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature." in: Histochemistry and cell biology, Vol. 142, Issue 3, pp. 245-56, (2014) (PubMed).

Nandhu, Hu, Cole, Erdreich-Epstein, Rodriguez-Gil, Viapiano: "Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas." in: Cancer research, Vol. 74, Issue 19, pp. 5435-48, (2014) (PubMed).

Aliases for LOX Proteins

lysyl oxidase (LOX) Proteins
lysyl oxidase (lox) Proteins
lysyl oxidase a (loxa) Proteins
lysyl oxidase L homeolog (lox.L) Proteins
lysyl oxidase (Lox) Proteins
AI893619 Proteins
H-rev142 Proteins
LOX Proteins
lox Proteins
MGC146507 Proteins
Rrg1 Proteins
TSC-160 Proteins
Xlox Proteins
zgc:77447 Proteins
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