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MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Proteins (MAD2L2)

The protein encoded by MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Additionally we are shipping MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAD2L2 71890 Q9D752
MAD2L2 10459 Q9UI95
MAD2L2 313702 D3Z8D9
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Top MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,520.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,520.83
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,520.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,520.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,520.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,520.83
Details

MAD2L2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

Rat (Rattus)

More Proteins for MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Interaction Partners

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) interaction partners

  1. Increased gonadotropins caused by the absence of functional oocytes and accumulation of DNA damage in cells caused by the lack of repair function could be responsible for the development and progression of ovarian tumors in the Rev7 mutant mouse.

  2. the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs (show NR2E3 Proteins)), depending on the growth conditions.

  3. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells

  4. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

  5. These results demonstrated that Rev7 is essential in resolving the replication stalls caused by DNA damage during S phase.

  6. The function of Mad2l2 is essential in PGCs, and thus of high relevance for fertility

  7. Rev7 is essential for PGC (show PGC Proteins) maintenance by prevention of apoptotic cell death in the mouse.

  8. identification of the Rev7 binding surface of the Rev1 C-terminal domain

Xenopus laevis MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) interaction partners

  1. We have successfully isolated Xenopus laevis Mad2B and PRCC (show PRCC Proteins) cDNAs, so the well-established animal model Xenopus laevis can be used as a powerful system to study in detail the role of xPRCC (show PRCC Proteins) and xMad2B in the intricate processes of cell cycle control.

Human MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) interaction partners

  1. hMAD2 also binds to the hREV7-binding sequence in hREV3, whereas hMAD2 does not bind to a similar sequence in ADAM9 (show ADAM9 Proteins) or ELK-1 (show ELK1 Proteins) and hREV7 does not bind to the hMAD2-binding sequence in hMAD1 or hCDC20.

  2. data establish MAD2L2 as a crucial contributor to the control of DNA repair activity by 53BP1 that promotes NHEJ by inhibiting 5' end resection downstream of RIF1

  3. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells

  4. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

  5. Rev7 is essential for mutagenesis and S phase progression in UV-irradiated fibroblasts.

  6. These findings indicate that depletion of REV7 enhances sensitivity to cisplatin treatment in ovarian clear cell carcinoma (CCC), suggesting that REV7 is a candidate molecular target in CCC management.

  7. MAD2L2 helps to ensure a robustly bistable switch between APC (show APC Proteins)/C(CDC20 (show CDC20 Proteins)) and APC (show APC Proteins)/C(CDH1 (show CDH1 Proteins)) during the metaphase-to-anaphase transition, thereby contributing to mitotic fidelity.

  8. REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1.

  9. MAD2B may mediate Sim2 (show SIM2 Proteins) function during development in CNS and thereby play a critical role in pathophysiological mechanisms in Down syndrome

  10. analysis of the crystal structure of the ternary complex composed of the C-terminal domain of human REV1, REV7, and a REV3 fragment

MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) (MAD2L2) Protein Profile

Protein Summary

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.

Gene names and symbols associated with MAD2L2

  • MAD2 mitotic arrest deficient-like 2 (mad2l2)
  • MAD2 mitotic arrest deficient-like 2 (yeast) (MAD2L2)
  • MAD2 mitotic arrest deficient-like 2 (Mad2l2)
  • MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2)
  • si:dkey-23c22.2 (si:dkey-23c22.2)
  • 2310033C13Rik protein
  • mad2B protein
  • mad2l2 protein
  • mad2l2-A protein
  • POLZ2 protein
  • REV7 protein
  • xMAD2L2 protein
  • zgc:110299 protein

Protein level used designations for MAD2L2

MAD2-like protein 2 , Mitotic arrest deficient 2-like protein 2 , mitotic spindle assembly checkpoint protein MAD2B , MAD2 homolog , mitotic arrest deficient 2-like protein 2 , Mitotic arrest defective protein 2B , MAD2 (mitotic arrest deficient, yeast, homolog)-like 2 , REV7 homolog , hREV7 , mitotic arrest deficient homolog-like 2 , polymerase (DNA-directed), zeta 2, accessory subunit

GENE ID SPECIES
448122 Xenopus (Silurana) tropicalis
457953 Pan troglodytes
714527 Macaca mulatta
71890 Mus musculus
394380 Xenopus laevis
10459 Homo sapiens
313702 Rattus norvegicus
506605 Bos taurus
419493 Gallus gallus
487443 Canis lupus familiaris
550258 Danio rerio
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