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Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Additionally we are shipping MYST Histone Acetyltransferase 2 Antibodies (99) and MYST Histone Acetyltransferase 2 Kits (3) and many more products for this protein.
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This study demonstrates that CRL4(DDB2 (show DDB2 Proteins)) is a novel ubiquitin ligase of HBO1.
Taken together, MYST2 is a repressed growth suppressor in AML (show RUNX1 Proteins) mediating reduced acetylation of histone 4 at residue 5 and is associated with inferior AML patient survival.
Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter
Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 (show PHF17 Proteins) shuttling during organ regeneration.
Hbo1 modulated transcription by estrogen receptor-alpha (show ESR1 Proteins). Hbo1 contributes to degradation of ER-alpha (show ESR1 Proteins) by ubiquitination through lysine 48.
HBO1, but not SRC-2 (show NCOA2 Proteins), expression was reduced in testes of patients with androgen insensitivity syndromes compared to normal testes.
Phosphorylated Hbo1 expression is associated with breast cancer.
alternate choice of subunits associated with HBO1 can switch its specificity between H4 and H3 tails
Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1.
Modulation of Fbxw15 levels was able to differentially regulate histone H3K14 acetylation and cellular proliferation by altering HBO1 levels.
MYST2 gene was cloned; results demonstrated that 2872G > A substitution was significantly associated with the litter size of all parities in Large White sows and Landrace sows
These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival
Taken together, MYST2 is a repressed growth suppressor in AML (show RUNX1 Proteins) mediating reduced acetylation of histone 4 at residue 5
Brd1 (show BRD1 Proteins)-mediated Hbo1 activity is crucial for efficient activation of CD8 (show CD8A Proteins) expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 (show CD8A Proteins) enhancers.
The Hbo1-Brd1 (show BRD1 Proteins) complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator (show GIPC1 Proteins) genes.
the primary role of HBO1 in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development
reveal a direct regulatory connection between p53 (show TP53 Proteins)-responsive stress signaling and Hbo1-dependent chromatin pathways
FAD24 (show NOC3L Proteins) controls DNA replication by recruiting HBO1 to origins of DNA replication and is required for MCE during adipocyte differentiation.
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription (By similarity).
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
, MYST histone acetyltransferase 2
, MYST protein 2
, histone acetyltransferase KAT7
, histone acetyltransferase MYST2
, histone acetyltransferase binding to ORC1
, lysine acetyltransferase 7