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Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Additionally we are shipping MAEL Kits (4) and MAEL Antibodies (4) and many more products for this protein.
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MAEL HMG (show SSRP1 Proteins)-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs.
an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells
This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs (show TES Proteins)) and identifies the initiation of meiosis as an important step in (TE) control in the male germline.
Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 (show PABPC1 Proteins) in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs (show FBN1 Proteins).
Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt (show AKT1 Proteins)/GSK-3beta/Snail (show SNAI1 Proteins) signaling.
These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation (show HELLS Proteins).
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).
protein maelstrom homolog
, cancer/testis antigen 128
, maelstrom homolog
, spermatogenesis associated 35