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Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004].. Additionally we are shipping Mahogunin RING Finger Protein 1 Proteins (6) and many more products for this protein.
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Human Monoclonal Mahogunin RING Finger Protein 1 Primary Antibody for WB - ABIN393376
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 5 references for ABIN393376
Chicken Polyclonal Mahogunin RING Finger Protein 1 Primary Antibody for WB - ABIN2774728
Kim, Olzmann, Barsh, Chin, Li: Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. in Molecular biology of the cell 2007
Mahogunin-mediated alpha-tubulin (show TUBA4A Antibodies) ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
data suggest that MGRN1 selectively targets misfolded proteins for degradation and may exhibit viable therapeutic potential for the treatment of spongiform neurodegeneration
It therefore seems probable that the role of MGRN1 in the adrenal relates to the trafficking and/or degradation of the melanocortin 2 receptor (show MC2R Antibodies).
a role for Mahogunin in a proteasome-independent ubiquitylation pathway: TSG101 (show TSG101 Antibodies) is a specific Mahogunin substrate
Study shows that both (Ctm)PrP and cyPrP can interact with and disrupt the function of Mahogunin (Mgrn), a cytosolic ubiquitin ligase whose loss causes spongiform neurodegeneration.
Findings suggest that mahogunin ring finger-1 contributes to the clearance of toxic mutant copper-zinc superoxide dismutase (show SOD1 Antibodies) inclusions likely through autophagic pathway.
ATRN (show ATRN Antibodies) also has no effect on prion (show PRNP Antibodies) disease onset or progression and discuss possible mechanisms that could cause vacuolation of the central nervous system in Mgrn1 and Atrn (show ATRN Antibodies) null mutant mice
pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4.
Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase (show MUL1 Antibodies) do not influence prion (show PRNP Antibodies) disease.
the md and mg mutations rescue the A(y) phenotypes by a primarily cAMP-independent mechanism promoting trafficking of MC4R and likely MC1R away from the lysosome toward the cell surface.
positional cloning of mahoganoid, encoding a novel 494-amino acid protein containing a C3HC4 RING (really interesting new gene) domain that may function as an E3 ubiquitin ligase (show MUL1 Antibodies)
a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion (show PRNP Antibodies) diseases but without accumulation of protease-resistant prion protein (show PRNP Antibodies)
Mahoganoid mutation (Mgrn1md) on insulin (show INS Antibodies) sensitivity suggests that Mgrn1md may be increasing insulin (show INS Antibodies) sensitivity via the hypothalamic melanocortin-3 receptor (show MC3R Antibodies) pathway.
Mgrn1 mutant embryos show abnormal expression of asymmetrically expressed genes involved in LR patterning.
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.
mahogunin, ring finger 1
, probable E3 ubiquitin-protein ligase MGRN1
, E3 ubiquitin-protein ligase MGRN1
, RING finger protein 156
, mahogunin RING finger protein 1
, mahogunin ring finger protein 1