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Plays a role in thermogenesis via beta-adrenergic signaling pathway. Additionally we are shipping MFSD2A Antibodies (29) and and many more products for this protein.
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A homozygous mutation affecting a highly conserved MFSD2A residue (p.Ser339Leu) is associated with a progressive microcephaly syndrome characterized by intellectual disability, spasticity and absent speech.
MFSD2A mutations impair brain lipid transport activity.
Several tagging SNPs and haplotypes in TRIT1 (show TRIT1 Proteins), MYCL1 and MFSD2A region are significantly associated with risk and clinicopathological features of gastric cancer in a Chinese population.
Importance of MFSD2a in trophoblast fusion and placenta development.
SNP rs12072037 modulates MFSD2A promoter activity and thus might affect MFSD2A levels in normal lung and in lung tumors.
MFSD2A is a putative Tunicamycin transporter at the plasma membrane.
MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment.
three additional SNPs in the MFSD2 genes showed ethnic differences in allelic frequencies
Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis.
MFSD2 is a placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2, and plays a role in placenta morphogenesis.
findings identify Mfsd2a as a key regulator of blood brain barrier function that may act by suppressing transcytosis in CNS endothelial cells.
identification of a member of the major facilitator superfamily--Mfsd2a (previously an orphan transporter)--as the major transporter for docosahexaenoic acid uptake into brain
Data suggest that the ligand(s) that are transported by MFSD2A play important roles in these physiological processes and await future identification.
Plays a role in thermogenesis via beta-adrenergic signaling pathway. May be the main plasma membrane tunicamycin transporter.
major facilitator superfamily domain containing 2
, major facilitator superfamily domain containing 2A
, major facilitator superfamily domain-containing protein 2A