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HLA-DOB belongs to the HLA class II beta chain paralogues. Additionally we are shipping HLA-DOB Antibodies (49) and many more products for this protein.
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TAP2 (show TAP2 Proteins), HLA-DOA (show HLA-DOA Proteins), HLA-DOB, and tapasin (show TAPBP Proteins) loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population
HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias.
In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation.
A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing.
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
HLA class II histocompatibility antigen, DO beta chain
, MHC class II antigen DOB