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Major Histocompatibility Complex, Class II, DO beta Proteins (HLA-DOB)

HLA-DOB belongs to the HLA class II beta chain paralogues. Additionally we are shipping HLA-DOB Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HLA-DOB 3112 P13765
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Top HLA-DOB Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details

HLA-DOB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Major Histocompatibility Complex, Class II, DO beta (HLA-DOB) Interaction Partners

Human Major Histocompatibility Complex, Class II, DO beta (HLA-DOB) interaction partners

  1. TAP2 (show TAP2 Proteins), HLA-DOA (show HLA-DOA Proteins), HLA-DOB, and tapasin (show TAPBP Proteins) loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population

  2. HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias.

  3. In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation.

  4. A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing.

HLA-DOB Protein Profile

Protein Summary

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Gene names and symbols associated with HLA-DOB

  • major histocompatibility complex, class II, DO beta (HLA-DOB)
  • DOB protein

Protein level used designations for HLA-DOB

HLA class II histocompatibility antigen, DO beta chain , MHC class II antigen DOB

GENE ID SPECIES
3112 Homo sapiens
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