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Matrix Metallopeptidase 12 (Macrophage Elastase) Proteins (MMP12)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP12 Antibodies (169) and MMP12 Kits (50) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP12 17381 P34960
MMP12 117033 Q63341
MMP12 4321 P39900
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Top MMP12 Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rabbit His tag 100 μg Log in to see 11 to 13 Days
$932.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$915.20
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,995.67
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,995.67
Details

MMP12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus) ,

Human , ,
,

More Proteins for Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) Interaction Partners

Mouse (Murine) Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.

  2. These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.

  3. study found significant increases of MMP-3 (show MMP3 Proteins) and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection

  4. The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 (show F2RL1 Proteins) might be related to MMP-12 production.

  5. MMP-12 up-regulation mediated by SARM (show SARM1 Proteins)-TRIF (show RNF138 Proteins) signaling pathway contributes to IFN-gamma (show IFNG Proteins)-independent airway inflammation and AHR (show AHR Proteins) post RSV infection in nude mice.

  6. MMP-12 and MMP-13 (show MMP13 Proteins) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

  7. Post-MI, MMP-12i impaired CD44 (show CD44 Proteins)-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.

  8. MMP12 upregulated in regenerating motor neurons of the mouse and rat facial nucleus; findings point to a role of MMP12 in the neuronal initiation of the synaptic stripping process

  9. abnormal neuronal expression of matrix metalloproteinase-12 may contribute to axonal degeneration in Niemann-Pick type C disease

  10. the results of this study show a close correlation between vascular injury markers, Arg 1 (show ARG1 Proteins)+ macrophage accumulation and fibrosis and suggest an important role of MMP-12 in regulating these processes.

Human Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.

  2. Productive complex between MMP-12 and synthetic triple-helical collagen V, are revealed through paramagnetic NMR.

  3. These results proved that MMP-12 expression was increased in cutaneous melanoma and associated with tumor progression. It also provided the first evidence that MMP-12 level could be an independent prognostic marker for patients with cutaneous melanoma

  4. Patients with Primary Open-Angle Glaucoma are characterized by an increased mRNA expression of MMP1 (show MMP1 Proteins), MMP9 (show MMP9 Proteins), MMP12, TIMP1 (show TIMP1 Proteins) and IL-1b (show IL1B Proteins) genes as compared to the control group .

  5. fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12.

  6. AG and GG genotypes of the MMP12 rs2276109 variant were significantly under-represented among patients with non-contact anterior cruciate ligament rupture compared to controls.

  7. findings showed that there was an important joint effect of the MMP-12 polymorphisms and Type 2 Diabetes Mellitus on the risk of Ischemic Stroke and therefore it can be considered as a potential marker of cerebrovascular disorders in diabetic patients.

  8. HnRNP K (show HNRNPK Proteins) can induce MMP12 expression and enzyme activity through activating MMP12 promoter, which promotes cell migration and invasion in nasopharyngeal carcinoma cells.

  9. We identified a novel association with an MMP12 locus in large artery atherosclerosis (rs660599; p = 2.5x10), with independent replication in a second population

  10. Thrombin (show F2 Proteins)-activated microglia expression of tumor necrosis factor (show TNF Proteins)-a (show GTF3A Proteins), interleukin-1b and MMP-12 was significantly reduced through contact-dependent and paracrine mechanisms when the HAESCs were co-cultured with microglia cells

Rabbit Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) interaction partners

  1. Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.

MMP12 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP12

  • matrix metallopeptidase 12 (macrophage elastase) (MMP12)
  • matrix metallopeptidase 12 (Mmp12)
  • AV378681 protein
  • HME protein
  • ME protein
  • MME protein
  • Mmel protein
  • MMP-12 protein
  • MMP12 protein

Protein level used designations for MMP12

matrix metallopeptidase 12 (macrophage elastase) , matrix metalloproteinase 12 , MME , MMP-12 , macrophage elastase , macrophage metalloelastase , macrophage-metalloelastase , matrix metalloproteinase-12 , matrix metalloproteinase 12 (macrophage elastase) , macrophage metalloelastase MMP-12

GENE ID SPECIES
451512 Pan troglodytes
17381 Mus musculus
117033 Rattus norvegicus
4321 Homo sapiens
100009559 Oryctolagus cuniculus
611789 Canis lupus familiaris
526981 Bos taurus
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