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Matrix Metallopeptidase 17 (Membrane-inserted) Proteins (MMP17)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping Matrix Metallopeptidase 17 (Membrane-inserted) Antibodies (84) and Matrix Metallopeptidase 17 (Membrane-inserted) Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP17 23948 Q9R0S3
Rat MMP17 MMP17 288626  
MMP17 4326 Q9ULZ9
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Top Matrix Metallopeptidase 17 (Membrane-inserted) Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 5 to 6 Days
$440.82
Details
HOST_Escherichia coli (E. coli) Human His tag   200 μg Log in to see 5 to 6 Days
$6,446.82
Details

MMP17 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) Interaction Partners

Mouse (Murine) Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) interaction partners

  1. Mmp17-mediated osteopontin cleavage regulated vascular SMC maturation via c-JNK during aorta wall development. Mmp17 proteolytic activity regulates vascular SMC phenotype in the arterial vessel wall. Its absence predisposes to thoracic aortic aneurysm.

  2. function and expression of MT4-MMP

  3. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation

  4. MT1 (show MT1 Proteins)-MT4-MMP chimaeras do not undergo normal trafficking and are not correctly processed to their fully active forms and, as a consequence, they are unable to activate pro-MMP-2 (show MMP2 Proteins) at the cell surface.

Human Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) interaction partners

  1. The MT4-MMP is internalized by the clathrin-independent carriers/GPI (show GNPDA1 Proteins)-enriched early endosomal compartments pathway, a mechanism that differs from that responsible for the internalization of other membrane-type MMP members.

  2. Screening of patients with inherited thoracic aortic aneurysms and dissections identified a missense mutation (R373H) in the MMP17 gene that prevented the expression of the protease in human transfected cells.

  3. A functional link between MT4-MMP and the growth factor receptor (show RYK Proteins) EGFR (show EGFR Proteins).

  4. CAV1 (show CAV1 Proteins) when found in lipid rafts does not allow the metalloproteinase MT4-MMP to localize into the lipid rafts, affecting its expression in the cell and probably its activity which is translated into the metastasis-associated activities of these cells.

  5. It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination.

  6. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation

  7. The data presented here provide a new insight into the characteristics of MT4-MMP and highlight the common and distinct properties of the glycosylphosphatidylinositol-anchored membrane type-matrix metalloproteinases.

  8. Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha (show HIF1A Proteins), and SLUG (show SNAI2 Proteins) regulation of MT4-MMP transcription.

  9. Data show that eosinophils constitutively express membrane type-4 matrix metalloproteinase (MT4-MMP), which is increased upon stimulation with tumor necrosis factor-alpha (show TNF Proteins).

  10. MT4-MMP and the proteoglycan (show Vcan Proteins) form of syndecan-1 (show SDC1 Proteins) have roles in ADAMTS-4 (show ADAMTS4 Proteins) activation on the cell surface

Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.

Gene names and symbols associated with MMP17

  • matrix metallopeptidase 17 (Mmp17)
  • matrix metallopeptidase 17 (membrane-inserted) (MMP17)
  • matrix metallopeptidase 17a (mmp17a)
  • mmp17 protein
  • MT4-MMP protein
  • MT4MMP protein
  • MTMMP4 protein

Protein level used designations for MMP17

MMP-17 , MT-MMP 4 , matrix metalloproteinase 17 , matrix metalloproteinase-17 , membrane type-4 matrix metalloproteinase , membrane-type matrix metalloproteinase 4 , membrane-type-4 matrix metalloproteinase , MT4MMP , MTMMP4 , matrix metalloproteinase 17 (membrane-inserted) , matrix metallopeptidase 17 (membrane-inserted)

GENE ID SPECIES
23948 Mus musculus
288626 Rattus norvegicus
4326 Homo sapiens
570076 Danio rerio
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