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May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Additionally we are shipping Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) Antibodies (124) and Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) Kits (16) and many more products for this protein.
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Authors revealed a novel interaction between MAGEA1 and the intracellular segment of NOTCH1 receptor (NICD1). MAGEA1 reduced NICD1's stability by promoting the ubiquitin modification of NICD1.
In patients with Colon cancer, the expression of MAGE (show MAGEB10 Proteins)-A(1-6) gene was associated with a poor prognosis.
MAGEA1 was expression in 15% of synovial sarcomas and was not associated with prognosis.
Data show that overall survival (OS) was significantly lower for patients expressing pan-MAGE (show MAGEB10 Proteins) or MAGE (show MAGEB10 Proteins)-A1/A3/A4 in both independent cohorts.
These data demonstrate that MAGE (show MAGEB10 Proteins)-A1-, MAGE-A3 (show MAGEA3 Proteins)-, and NY-ESO-1 (show CTAG1B Proteins)-specific T cells with antigen-specific cytotoxicity can be cultured from healthy donors and patient-derived cells making adoptive immunotherapy with these cytotoxic T lymphocyte feasible.
up-regulation of MAGE (show MAGEB10 Proteins)-A1 dramatically promoted proliferation, migration, and invasion of human melanoma cell lines in vitro
The overall survival of laryngeal squamous cell carcinoma patients with positive MAGE-A1, MAGE-A9, or MAGE-A11 expression was lower than the patients without MAGE-A1, MAGE-A9, or MAGE-A11 expression.
MAGE (show MAGEB10 Proteins)-A is more highly expressed than NY-ESO-1 (show CTAG1B Proteins) in a majority of human malignancies
TRIM31 directly binds to NSE4, suggesting the existence of a TRIM31-MAGEA1-NSE4 complex reminiscent of the NSE1-NSE3-NSE4 trimer.
Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein.
results indicate that the fusion of Hsp70 (show HSP70 Proteins) to Mage (show MAGEB10 Proteins)-a1 can enhance immune responses and anti-tumor effects against Mage (show MAGEB10 Proteins)-a1-expressing tumors
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
, antigen MZ2-E
, cancer/testis antigen 1.1
, cancer/testis antigen family 1, member 1
, melanoma antigen MAGE-1
, melanoma antigen family A 1
, melanoma-associated antigen 1
, melanoma-associated antigen MZ2-E
, melanoma antigen family A, 1