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The protein encoded by MMEL1 is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Additionally we are shipping Membrane Metallo-Endopeptidase-Like 1 Antibodies (55) and Membrane Metallo-Endopeptidase-Like 1 Proteins (7) and many more products for this protein.
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the dynamic behavior of human NEP (show MME ELISA Kits) and NEP2 proteins was monitored by conducting molecular dynamics (MD) simulations.
MMEL1 518 Met/Thr (show TRH ELISA Kits) polymorphism contributes to celiac disease risk among Saudi Arabians, both in single and also in synergistic cooperation with SH2B3 (show SH2B3 ELISA Kits) gene marker.
Te results of this study suggested taht genetic variations in MMEL1, ECE1 (show ECE1 ELISA Kits), ECE2 (show ECE2 ELISA Kits), AGER (show AGER ELISA Kits), PLG (show PLG ELISA Kits), PLAT (show PLAT ELISA Kits), NR1H3 (show NR1H3 ELISA Kits), MMP3 (show MMP3 ELISA Kits), LRP1 (show LRP1 ELISA Kits), TTR (show TTR ELISA Kits), NR1H2 (show NR1H2 ELISA Kits), and MMP9 (show MMP9 ELISA Kits) genes do not play major role among the Finnish AD patient cohort.
The NEP2 expression and activity are altered in MCI is significant as these changes may potentially serve as preclinical markers for AD and reduced NEP2 activity may be associated with the development of Alzheimer's disease.
This study identifies MMEL1 and CTLA4 as RA susceptibility genes, in Han Chinese popilation.
A combined analysis of the nsSNP screen and replication data provides evidence implicating a novel additional locus, rs3748816 in membrane metalloendopeptidase (show THOP1 ELISA Kits)-like 1 in multiple sclerosis susceptibility.
NEP2 substrate specificity and inhibitor binding was distinct from that of human NEP (show MME ELISA Kits), suggesting that NEP (show MME ELISA Kits) and NEP2 play distinct physiological roles in humans.
This study demonstrated that Cortical fast-spiking parvalbumin (show PVALB ELISA Kits) interneurons enwrapped in the perineuronal net express the Neprilysin (show MME ELISA Kits) in mice.
neprilysin (show MME ELISA Kits) x ABCC1 (show ABCC1 ELISA Kits) double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes
Data show that intranasal delivery of drugs can be used to model Alzheimer disease and suggest that other phosphoramidon-sensitive peptidases are degrading amyloid beta in neprilysin (show MME ELISA Kits)/NEP2-deficient mice.
In NEP (show MME ELISA Kits)/NEP2 double-knockout mice, Abeta (show APP ELISA Kits) levels were marginally increased ( approximately 1.5- to 2-fold), compared with NEP (show MME ELISA Kits)(-/-)/NEP2(+/+) controls.
One of the roles of NL1 in mice is related to sperm function. NL1 modulates the processes of fertilization and early embryonic development in vivo.
Modification of the structure of the C-terminal region will either impair substrate hydrolysis or completely abolish the secretion and enzymatic activity of the secreted isoform of rat NEP2.
Intracellular transport and secretion of NEP2 is regulated by processes such as glycosylation, endoplasmic reticulum-Golgi transport, and intracellular calcium levels.
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.
membrane metallo-endopeptidase-like 1
, membrane metallo-endopeptidase-like 1-like
, membrane metallo-endopeptidase-like 2
, neprilysin II
, soluble secreted endopeptidase
, zinc metallopeptidase
, NEPLP alpha
, NEPLP beta
, NEPLP gamma
, mel transforming oncogene-like 1
, neprilysin 2
, neprilysin-like 1
, neprilysin-like peptidase