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alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b. Additionally we are shipping Meprin A, alpha (PABA Peptide Hydrolase) Antibodies (71) and Meprin A, alpha (PABA Peptide Hydrolase) Proteins (10) and many more products for this protein.
Showing 7 out of 24 products:
no significant dentin malformation was observed in Mep1b (show MEP1B ELISA Kits) (-/-) or Mep1a (-/-) deficient mice.
meprin alpha and meprin beta (show MEP1B ELISA Kits) join the modulators of Reelin (show RELN ELISA Kits) signalling as they cleave Reelin (show RELN ELISA Kits) at a specific site and are upregulated under specific pathological conditions.
While meprin A only cleaved protein kinase A (PKA) catalytic subunit beta1, meprin B (show MEP1B ELISA Kits) cleaved all three PKA catalytic isoforms.
meprin alpha and meprin beta (show MEP1B ELISA Kits) are unique in their ability to process and release both C- and N-propeptides from type I procollagen (show COL1A2 ELISA Kits) in vitro and in vivo
the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock
Absence of meprin A aggravates chronic inflammation and lack of meprin B (show MEP1B ELISA Kits) affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.
meprin-alpha may play a role in the pathogenesis of diabetic nephropathy and the benefits of ACE (show ACE ELISA Kits) inhibitor therapy
meprin A, a multimeric metalloprotease expressed in the brush borders of kidney proximal tubules initially truncates mouse BNP in the N terminus to mBNP7-32
meprin alpha/beta null (alpha(-/-)/beta(-/-)) mice had decreased prevalence of resident monocytes and natural killer (NK) cells in blood, with a concomitant accumulation of inflammatory monocytes and NK cells in bone marrow.
MEP1A is a UC susceptibility gene and indicate that decreased meprin-alpha expression is associated with intestinal inflammation in IBD patients and in a mouse experimental model of IBD.
Results showed that MEP1A expression was elevated in colorectal cancer (CRC (show CALR ELISA Kits)) tissues at both the mRNA and protein levels, and provided evidence for its functionally crucial role in CRC (show CALR ELISA Kits) carcinogenesis as tumor proliferation and invasion.
Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin (show INS ELISA Kits) metabolism in overweight/obese central European women with polycystic ovary syndrome.
Meprin metalloproteases A and B inactivate interleukin 6 (show IL6 ELISA Kits)
Proteolytically active meprinalpha leads to an increase in EGFR (show EGFR ELISA Kits) and ERK1/2 (show MAPK1/3 ELISA Kits) phosphorylation and subsequently enhances cell proliferation and migration
The present results indicate that a TNF-alpha (show TNF ELISA Kits)-mediated down-regulation of CDX2 (show CDX2 ELISA Kits) can be related to suppressed expression of MEP1A during intestinal inflammation.
Meprin-alpha activity is regulated differently in primary tumors and metastases of colorectal cancer. By virtue of its pro-migratory and pro-angiogenic activity, meprin-alpha may promote tumor progression in colorectal cancer.
Cystatin C (show CST3 ELISA Kits) was an inhibitor for human meprin alpha(K(i) = 8.5 x 10(-6) M) but, interestingly, not for meprin beta (show MEP1B ELISA Kits).
activation in colorectal cancer triggered by the plasminogen (show PLG ELISA Kits)-activating system
Mephrin beta induced a dramatic change in cell morphology and reduced the cell number, indicating a function in terminal differentiation, whereas meprin alpha did not affect cell viability, and may play a role in basal keratinocyte proliferation.
alpha subunit of meprin metalloproteases, which form homotetramers and heterodimers with beta subunit Mep1b
, endopeptidase-24.18 subunit alpha
, meprin A alpha
, meprin A subunit alpha
, meprin A alpha-subunit
, meprin alpha
, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha
, PABA peptide hydrolase
, PPH alpha
, bA268F1.1 (meprin A alpha (PABA peptide hydrolase))