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MFAP5 encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. Additionally we are shipping MFAP5 Proteins (14) and MFAP5 Kits (7) and many more products for this protein.
Showing 10 out of 45 products:
Human Polyclonal MFAP5 Primary Antibody for EIA, WB - ABIN155193
Gibson, Hatzinikolas, Kumaratilake, Sandberg, Nicholl, Sutherland, Cleary: Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25) in The Journal of biological chemistry 1996
Show all 5 references for ABIN155193
Human Polyclonal MFAP5 Primary Antibody for ELISA, WB - ABIN563536
Luistro, He, Smith, Packman, Vilenchik, Carvajal, Roberts, Cai, Berkofsky-Fessler, Hilton, Linn, Flohr, Jakob-Røtne, Jacobsen, Glenn, Heimbrook, Boylan: Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. in Cancer research 2009
Human Polyclonal MFAP5 Primary Antibody for IHC, IHC (p) - ABIN4332461
Leung, Yeung, Yip, Pradeep, Balasubramanian, Liu, Wong, Mangala, Armaiz-Pena, Lopez-Berestein, Sood, Birrer, Mok: Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. in Nature communications 2014
The results answer the question of how MAGP2 controls cell type dependent Notch (show NOTCH1 Antibodies) signaling, but more importantly uncover a new mechanism to understand how extracellular matrices and cellular environments impact Notch (show NOTCH1 Antibodies) signaling.
Our results demonstrate that factors involving low-grade inflammation modulate MFAP5 expression and that the modified expression of MFAP5 may further regulate adipose tissue inflammation.
FAK (show PTK2 Antibodies)/CREB (show CREB1 Antibodies)/TNNC1 (show TNNC1 Antibodies) has a role in mediating the effect of stromal MFAP5 on ovarian cancer metastatic potential
Alteration of MAGP-2, a component of microfibrils and elastic fibers, appears as an initiating mechanism of inherited Thoracic aortic aneurysm and dissection (TAAD).
EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 and PENK (show PENK Antibodies) that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit
Decreased MFAP5 gene expression in the endometrium of patients with implantation failure after in vitro ertilization treatment
The MAGP2-based assay provided superior performance for the purpose of cell culture identification compared to assays using standard reference genes.
microfibrillar proteins MAGP-1 (show MFAP2 Antibodies) and MAGP-2 can function outside of their role in elastic fibers to activate a cellular signaling pathway
MAGP-2 promotes angiogenic cell spouting in vitro by antagonizing Notch (show NOTCH1 Antibodies) signaling pathways in endothelial cells.
Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis in advanced ovarian cancer
Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
Loss of MAGP2 expression in vivo has pleiotropic effects.
interaction with fibrillin-1 (show FBN1 Antibodies) and fibrillin-2 (show FBN2 Antibodies) suggesting role in elastic fiber assembly
Tight skin fibrillin 1 (show FBN1 Antibodies) altered extracellular matrix organization and caused fibrosis by affecting deposition of MAGP-2 or other fibrillin-1 (show FBN1 Antibodies)-associated proteins.
microfibril-associated MAGP-2 may stimulate elastic fiber macroassembly by targeting the release of elastin (show ELN Antibodies) globules from the cell membrane onto developing elastic fibers
MAGP-2 is identified as a novel regulator of angiogenesis.
results show MAGP-2 is covalently and periodically located along the fibrillin-containing microfibrils of the developing nuchal ligament, suggesting that it is an integral component of most if not all of the microfibrils in this elastic fiber-rich tissue
This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.
microfibrillar associated protein 5
, microfibril-associated glycoprotein 2
, microfibril-associated glycoprotein-2
, microfibrillar-associated protein 5