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This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. Additionally we are shipping Mitochondrial Fission Factor Antibodies (55) and many more products for this protein.
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We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations
membrane-anchored Mff differentially regulates various Drp1 isoforms.
Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC).
loss of Mff results in failure of Parkin (show PARK2 Proteins) translocation and final clearance of damaged mitochondria
Mitochondrial fission factor (MFF) mRNA is a direct target of miR (show MLXIP Proteins)-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region.
MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria.
TRAP1 (show TRAP1 Proteins) controls mitochondrial fusion/fission balance through Drp1 (show CRMP1 Proteins) and Mff expression.
PEX11 proteins attract both Mff and human Fis1 (hFis1 (show FIS1 Proteins)) to their site of action.
MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS (show ROS1 Proteins) production, and the onset of autophagy and mitophagy.
MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
MiD51 (show SMCR7L Proteins) can suppress Mff-dependent enhancement of Drp1 (show CRMP1 Proteins) GTPase (show RACGAP1 Proteins) activity.
Mff cannot bind to assembly-deficient mutants of Drp1, suggesting that Mff selectively interacts with higher-order complexes of Drp1.
These findings provide a mechanism wherein the multimeric states of both Mff and Drp1 regulate their collaborative interaction.
Ablating Mfn1 (show MFN1 Proteins) eliminates the cardiac-related lethality of Mff knockout mice.
Mitochondrial fission factor has been identified as a new AMPK (show PRKAA1 Proteins) substrate.
This study reveals a novel model of mitochondrial fission regulation, which is composed of miR (show MLXIP Proteins)-761 and mitochondrial fission factor
immunofluorescence analysis of Drp1 suggests that Fis1 and Mff are important for the number and size of Drp1 puncta on mitochondria.
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
mitochondrial fission factor homolog B
, mitochondrial fission factor homolog A
, mitochondrial fission factor
, Uncharacterized protein C2orf33 homolog