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MNX1 encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Additionally we are shipping MNX1 Antibodies (47) and MNX1 Kits (3) and many more products for this protein.
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The nuclear positioning of the HLXB9 gene was monitored at different stages.
study reports the results of MNX1 mutational screening in a series of 28 cases suspected having Currarino Syndrome and characterization of 10 novel mutations
NKX2-2 (show Nkx2-2 Proteins) and MNX1 are etiological genes for neonatal diabetes.
Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin (show MEN1 Proteins) knockdown, in MEN1 (show MEN1 Proteins)-associated beta cell tumors (insulinomas)
study describes a Norwegian family with typical Currarino syndrome in which a heterozygous deletion removes the entire MNX1 gene but no other known genes; also report MNX1 mutations in 3other Norwegian families and confirm that the GCC12 repeat (c.373_375) is a normal allelic variant
HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells.
a new HLXB9 gene mutation identified in a Chinese family with members suffering from Currarino syndrome
two novel mutations in the MNX1 gene in cases with Currarino syndrome
Hypermethylation of HLXB9 results in loss of expression and is associated with acute lymphoblastic leukemia.
HLXB9 is overexpressed in patients with infantile acute myeloid leukemia (show BCL11A Proteins).
Inactivating Mnx1 in embryonic beta-cells (Mnx1(Deltabeta)) caused beta-to-delta-like (show DLK1 Proteins) cell transdifferentiation, which was delayed until postnatal stages; findings identify Mnx1 as an important factor in beta-cell differentiation and proliferation.
provide mechanistic insights into the role of phospho-HLXB9 as a pro-oncogenic factor by interacting with a survival factor and by promoting the oncogenic c-Met pathway
Hlxb9 expression is increased in mouse islet tumor.
we developed recombinant lentiviral vectors carrying motor neuron specific regulatory sequences derived from the promoter of homeobox gene Hb9
Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of Ptf1a (show PTF1A Proteins) and is regulated by a distant enhancer element.
This study suggested that Hb9 interneurons are part of the sensorimotor circuitry that regulates the pattern of locomotor rhythms in the isolated cord.
the molecular pathways regulating Hb9 expression are evolutionarily conserved, and that MN-specific gene expression may be directed and achieved using a small 125-bp 5 (show HSPD1 Proteins)' enhancer
Hb9+ interneurons exhibit strong postinhibitory rebound and demonstrate pronounced membrane potential oscillations in response to chemical stimuli that induce locomotor activity.
loss of Pax6b (show PAX6 Proteins) or Hb9 independently results in the loss of insulin (show INS Proteins) expression, the data reveal a novel cross-talk between the two essential regulators of early beta-cell differentiation.
These data confirm our previous findings that Mnx1 is important for beta cell fates both in dorsal and ventral bud-derived beta cells.
This study demonistrated that Zebrafish Mnx (show KRT86 Proteins) proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics.
Data suggest that Mnx1 functions to promote beta and suppress alpha cell fates in the developing pancreas.
Essential for differentiation of the insulin (show INS Proteins)-producing beta-cells but not morphogenesis of pancreas.
This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
motor neuron and pancreas homeobox 1
, motor neuron homeobox transcription factor
, homeobox HB9
, homeobox protein HB9
, motor neuron and pancreas homeobox protein 1
, homeobox gene HB9
, uncharacterized protein LOC682076
, homeo box HB9