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MSI2 encodes a protein containing two conserved tandem RNA recognition motifs. Additionally we are shipping MSI2 Antibodies (99) and MSI2 Kits (1) and many more products for this protein.
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This line provides a valuable tool both for live imaging of the endogenous Msi2b at subcellular resolution and manipulation of Msi2b-expressing cells.
High Musashi2 expression is associated with pancreatic cancer.
MSI2 regulates myeloid leukemia (show BCL11A Proteins) stem cells gene expression.
these findings provide evidence that DBC2 (show RHOBTB2 Proteins) suppresses tumorigenesis in breast cancer by ubiquitinating MSI2.
Differential methylation of the MSI2 gene (chr17:55484635) in blood and islet cells is strongly related to hyperglycemia.
our findings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 (show ESR1 Proteins) and revealed the clinical relevance of the RNA-binding protein (show PTBP1 Proteins) MSI2 in breast cancer.
MSI2 might play a crucial role in sustaining stemness and chemoresistance of liver cancer stem cells in LIN28A (show LIN28A Proteins)-dependent manner in hepatocellular carcinoma.
MSI2 and FLT3 (show FLT3 Proteins) are significantly co-regulated in human AML (show RUNX1 Proteins)
MSI2 provides essential support for TGFbetaR1/SMAD3 (show SMAD3 Proteins) signaling and contributes to invasive adenocarcinoma of the lung and may serve as a predictive biomarker of NSCLC aggressiveness
Overexpression of Msi2 significantly increased and silencing of Msi2 reduced the phosphorylation of JAK2 (show JAK2 Proteins) and its downstream effecter STAT3 (show STAT3 Proteins).
MSI2 overexpression induces paclitaxel resistance in ovarian cancer.
Absence of Musashi2 in osteoclast precursors promotes apoptosis and inhibits RANKL (show TNFSF11 Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation, which is essential for osteoclast survival.
Msi2 primarily recognizes mRNA 3'UTRs at sites enriched in multiple copies of UAG motifs in epithelial progenitor cells.
Msi (show EBP Proteins) proteins are dispensable for normal homeostasis and self-renewal of the active intestinal stem cell.
our findings reveal the importance of Msi2 in suppressing hair regeneration and maintaining hair follicle stem cells quiescence
studies highlight Msi (show EBP Proteins) reporters as a unique tool to identify therapy resistance, and define Msi (show EBP Proteins) signalling as a central regulator of pancreatic cancer
MSI1 (show MSI1 Proteins) and MSI2 display distinct expression profiles during mammalian folliculogenesis and that MSI2 is required for pre-antral follicle development
Through expression studies and utilizing a transgenic Msi1 (show MSI1 Proteins) testis-specific (show AIF1 Proteins) overexpression model, we have identified 2 unique RNA-binding targets of MSI1 (show MSI1 Proteins) in spermatogonia, Msi2 and Erh (show ERH Proteins), and have demonstrated a role for MSI1 (show MSI1 Proteins) in translational regulation.
Msi (show EBP Proteins) proteins contribute to an epithelial gene expression program in neural and mammary cell types.
Msi2 is an important regulator of the hematopoietic stem cell (HSC (show FUT1 Proteins)) translatome and balances HSC (show FUT1 Proteins) homeostasis and lineage bias.
Ectopic expression of Musashi 2 isoform 1, but not isoform 2, enhanced the cloning efficiency of embryonic stem cells, but both isoforms were required for the self-renewal of embryonic stem cells.
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene.
musashi homolog 2 (Drosophila)
, musashi homolog 2
, musashi 2
, RNA-binding protein Musashi homolog 2
, Musashi homolog 2