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MRAS encodes a member of the Ras family of small GTPases. Additionally we are shipping Muscle RAS Oncogene Homolog Antibodies (33) and Muscle RAS Oncogene Homolog Kits (1) and many more products for this protein.
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Mras acts at a late step of neurogenesis and is required for neuronal differentiation.
Expression of the muscarinic M2 and M3 receptors that mediate the cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras-/- males and females, although only males exhibited a urinary phenotype.
Overexpression of MRAS in mouse embryonic stem cells leads to different cellular phenotypes.
succeed in solving two crystal structures corresponding to state 1 and state 2 from a single Ras polypeptide, M-RasD41E, carrying an H-Ras (show HRAS Proteins)-type substitution in residue 41
X-ray crystal structure analyses of a series of mutant H-Ras (show HRAS Proteins) and M-Ras in complex with guanosine 5'-(beta,gamma-imido)triphosphate (GppNHp), representing various intermediate states of the transition, were determined.
These results imply that M-Ras, induced and activated by BMP-2 (show BMP2 Proteins) signaling, participates in the osteoblastic determination, differentiation, and transdifferentiation under p38 MAPK (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) regulation
Expression of activated mutants of M-Ras was sufficient for oncogenic transformation of a murine mammary epithelial cell line
Showed that multiple aspects of the transformed phenotype induced by activated G22V M-Ras in a murine mammary epithelial cell line scp-2 (show CRISP3 Proteins) were dependent on an autocrine mechanism.
Data describe the crystal structure of M-Ras in the GDP-bound and guanosine 5'-(beta,gamma-imido)triphosphate (Gpp(NH)p)-bound forms.
Endogenous M-Ras was activated by several trophic factors in astrocytes, including epidermal growth factor (EGF (show EGF Proteins)), basic fibroblast growth factor (show FGF2 Proteins), and hepatocyte growth factor (show HGF Proteins). M-Ras activation by EGF (show EGF Proteins) was more sustained compared to prototypic Ras.
These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1 (show TERF2IP Proteins), mediated by RA-GEF-2 (show RAPGEF6 Proteins), in adhesion signaling.
The association of the MARS rs6782181 polymorphism and serum lipid levels is different between the Mulao and Han populations, or between males and females in the both ethnic groups.
The MRAS gene loci might have a minor effect in conferring susceptibility to coronary artery disease in the Chinese population.
Both MRAS and SHOC2 (show SHOC2 Proteins) play a key role in polarized migration.
implicated in a novel pathway of neuronal differentiation by coupling specific trophic factors to the MAPK (show MAPK1 Proteins) cascade through the activation of B-Raf (show SNRPE Proteins)
These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1 (show RABGEF1 Proteins), mediated by RA-GEF-2 (show RAPGEF6 Proteins), in adhesion signaling.
Identification of one new CAD risk locus on 3q22.3 in MRAS, and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43.
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ras-related protein M-Ras
, muscle RAS oncogene homolog
, RAB5B, member RAS oncogene family
, ras-related protein R-Ras3
, muscle and microspikes RAS