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anti-Muscleblind-Like 2 (Drosophila) (MBNL2) Antibodies

MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. Additionally we are shipping MBNL2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MBNL2 105559 Q8C181
MBNL2 10150 Q5VZF2
MBNL2 680445 F2Z3T4
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Top anti-MBNL2 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of Hela cells using MBNL2 Antibody (C-term) Cat.-No AP52623PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with MBNL2 Antibody (C-term) followed which was peroxidase conjugated to the secondary antibody and followed by AB staining. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-MBNL2 Antibody Titration: 0.2-1 ug/mlPositive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB MBNL2 Antibody (C-term)  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MBNL2 antibody detected the MBNL2 protein (arrow). MBNL2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBNL2 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Alkaline Phosphatase (AP) FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated IF, ELISA Detection limit for recombinant GST tagged MBNL2 is 0.03 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to MBNL2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB MBNL2 antibody used at 0.2-1 ug/ml to detect target protein. 50 μg Log in to see 7 to 9 Days
$473.93
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

MBNL2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


Human , ,
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Rat (Rattus)


Top referenced anti-MBNL2 Antibodies

  1. Human Polyclonal MBNL2 Primary Antibody for EIA, FACS - ABIN953337 : Adereth, Dammai, Kose, Li, Hsu: RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1. in Nature cell biology 2005 (PubMed)
    Show all 3 references for ABIN953337

More Antibodies against MBNL2 Interaction Partners

Mouse (Murine) Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Depletion of Mbnl1 (show MBNL1 Antibodies) and/or Mbnl2 reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  2. Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 (show MBNL1 Antibodies) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  3. depletion of Mbnl (show MBNL1 Antibodies) proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  4. consistent with a central and negative regulatory role for MBNL (show MBNL1 Antibodies) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  5. This analysis identified several hundred splicing events whose regulation depended on Mbnl (show MBNL1 Antibodies) function in a pattern indicating functional interchangeability between Mbnl1 (show MBNL1 Antibodies) and Mbnl2.

  6. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  7. Conserved developmental stage- and tissue-specific alternative splicing of MBNL (show MBNL1 Antibodies) transcripts is an important mechanism by which MBNL (show MBNL1 Antibodies) activity is regulated during embryonic development.

  8. The authors propose that expanded CTG DNA repeats cause two separate effects: loss of Mbnl1 (show MBNL1 Antibodies) function (disrupting splicing) and loss of another function that disrupts extracellular matrix mRNA regulation, possibly mediated by Mbnl2.

  9. MBNL2 contribute to the pathogenesis of myotonic dystrophy.

Zebrafish Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the myotonic dystrophy phenotype.

Human Muscleblind-Like 2 (Drosophila) (MBNL2) interaction partners

  1. Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 (show MBNL1 Antibodies) and MBNL2 proteins and accumulate in myotonic dystrophy 1 tissues during development.

  2. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both

  3. consistent with a central and negative regulatory role for MBNL (show MBNL1 Antibodies) proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  4. We propose that major pathological features of the myotonic dystrophy brain result from disruption of the MBNL2-mediated developmental splicing program

  5. MBNL (show MBNL1 Antibodies) proteins promote opposite splicing patterns for cardiac troponin T (show TNNT2 Antibodies) and insulin receptor (show INSR Antibodies) alternative exons

  6. MBNL1 (show MBNL1 Antibodies) and MBNL2 always co-distributed. Functional differences between MBNL1 (show MBNL1 Antibodies) and MBNL2 have not yet been found

  7. solution structures of both tandem zinc finger (TZF (show Znf318 Antibodies)) motifs, TZF12 (comprising ZF1 (show PRMT1 Antibodies) and ZF2 (show ZNF274 Antibodies)) and TZF34 (ZF3 and ZF4), in MBNL2

MBNL2 Antigen Profile

Protein Summary

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.

Gene names and symbols associated with MBNL2

  • muscleblind-like 2 (Mbnl2) antibody
  • muscleblind-like 2 (Drosophila) (mbnl2) antibody
  • muscleblind-like 2 (Drosophila) (MBNL2) antibody
  • muscleblind-like splicing regulator 2 (MBNL2) antibody
  • muscleblind-like splicing regulator 2 (Mbnl2) antibody
  • 1110002M11Rik antibody
  • AI047808 antibody
  • AI837313 antibody
  • AI849185 antibody
  • AL118326 antibody
  • MBLL antibody
  • MBLL39 antibody
  • mKIAA4072 antibody
  • PRO2032 antibody
  • R75232 antibody
  • wu:fj89c04 antibody

Protein level used designations for MBNL2

muscleblind-like protein 2 , fj89c04 , muscleblind-like 2 , muscleblind-like protein 1 , muscleblind-like protein-like 39

GENE ID SPECIES
105559 Mus musculus
560384 Danio rerio
418784 Gallus gallus
527679 Bos taurus
10150 Homo sapiens
612815 Canis lupus familiaris
680445 Rattus norvegicus
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