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The protein encoded by MAL is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. Additionally we are shipping MAL Antibodies (55) and MAL Kits (5) and many more products for this protein.
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This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 (show CADM1 Proteins) and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas
CADM1 (show CADM1 Proteins)/MAL methylation increases with severity of cervical intraepithelial neoplasia
Hypermethylation of the selected markers (MAL, PRIMA1 (show PRIMA1 Proteins), PTGDR (show PTGDR Proteins) and SFRP1 (show SFRP1 Proteins)) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL.
The use of CADM1 (show CADM1 Proteins), MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus.
MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells.
MAL hypermethylation is associated with esophageal carcinoma progression.
Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as triage tool on cervical scrapes of HPV positive women.
Docking and physicochemical studies indicated that BTK (show BTK Proteins) was involved in close contact with Tyr86 and Tyr106 of MAL, whereas PKCdelta (show PKCd Proteins) may phosphorylate Tyr106 only.
DNA methylation (show HELLS Proteins) analysis of CADM1 (show CADM1 Proteins), MAL and miR124-2 in cervical scrapes consistently detects cervical cancer
SYP (show SYP Proteins) is an hexameric MAL-domain channel protein.
Expression of the developmentally regulated proteolipid MAL (show TIRAP Proteins) is required for the cytotoxic effect of Clostridium perfringens Epsilon Toxin.
MAL (show TIRAP Proteins) overexpression leads to reduced expression of Mpz and p75NTR (show NGFR Proteins), despite functional pathways and normal expression of genes important for Schwann cell differentiation.
the exclusion of MAL (show TIRAP Proteins) from the expanding 2D crystals of uroplakins explains the selective association of MAL (show TIRAP Proteins) with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
Phagosomal retention of Francisella tularensis results in TIRAP/Mal (show TIRAP Proteins)-independent TLR2 signaling.
The specific reduction and mistargeting of MAL protein (show Mall Proteins) as a reaction to sulfatide overload may contribute to the pathogenic mechanisms in metachromatic leukodystrophy.
Our results demonstrate a critical role for MAL (show TIRAP Proteins) in the maintenance of central nervous system paranodes, likely by controlling the trafficking and/or sorting of NF155 and other membrane components in oligodendrocytes.
Our results suggest a functional role for MAL (show TIRAP Proteins) in peripheral myelination by influencing the expression of membrane components that mediate axon-glia interaction during ensheathment and myelin wrapping.
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.
myelin and lymphocyte protein
, Myelin and lymphocyte protein
, T-lymphocyte maturation-associated protein
, 17 kDa myelin vesicular protein
, NS 3
, myelin and lymphocyte protein, T-cell differentiation protein
, VIP17 proteolipid
, VIP17/MAL proteolipid