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Myosin Heavy Chain 6, Cardiac Muscle, alpha Proteins (MYH6)

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. Additionally we are shipping Myosin Heavy Chain 6, Cardiac Muscle, alpha Antibodies (27) and Myosin Heavy Chain 6, Cardiac Muscle, alpha Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYH6 4624 P13533
MYH6 29556  
Mouse MYH6 MYH6 17888 Q02566
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Top Myosin Heavy Chain 6, Cardiac Muscle, alpha Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,309.17
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MYH6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Rat (Rattus)

More Proteins for Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) Interaction Partners

Human Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. Data show that compound heterozygosity for recessive myosin heavy chain 6 (MYH6) mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejection fraction.

  2. human alpha- and beta-cardiac myosin, as well as the mutants, show opposite mechanical and enzymatic phenotypes with respect to each other.

  3. The novel MYH6 mutation delE933 causes both structural damage of the sarcomere and functional impairments on atrial action propagation.

  4. Data from molecular dynamic/docking simulations suggest that actin-myosin binding free energy accepts contributions from both electrostatic and nonpolar forces; studies compare cardiac alpha-myosin, beta-myosin, and fast skeletal muscle myosin.

  5. R1165C mutation in MYH9 (show MYH9 Proteins) gene is associated with macroscopic hematuria and presenile cataract.

  6. Perturbations in the MYH6 head domain seem to play a major role in the genetic origin of familial Secundum-type atrial septal defects.

  7. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4 (show CD4 Proteins)+ T cells in myocarditis

  8. data indicate that functional variants of MYH6 are associated with cardiac malformations in addition to atrial septal defect and provide a novel potential mechanism

  9. The mutations in MYH6 cause when a genetic cause can be identified, which has estimated to occur in 65% of hypertrophic cardiomyopathy.

  10. Our data provide evidence for a novel form of calcium-independent positive inotropy in failing cardiac myocytes by fast alpha-myosin motor protein gene transfer.

Mouse (Murine) Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. The stress-induced Brg1 (show SMARCA4 Proteins)-G9a (show EHMT2 Proteins)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  2. Data indicate that the cardiac myosin heavy chain alpha isoform (alphaMHC(403)) transgenic model closely recapitulates human disease.

  3. Transfecting human beta-MHC (show MYH7 Proteins) V606M into the mouse cardiac alpha-MHC gene caused hypertrophic cardiomyopathy without left ventricular hypertrophy, disarray of myofibers, and interstitial fibrosis. Cyclosporine or Arg453Cys or Arg719Trp worsened the phenotype.

  4. Mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein (show TNNT2 Proteins) expression.

  5. Results indicate the downstream targets of insulin (show INS Proteins), cyclin D1 (show CCND1 Proteins), BAD, alpha-MHC, and GATA-4 (show GATA4 Proteins), elucidate a molecular mechanism of insulin (show INS Proteins) in promoting cell proliferation and differentiation.

  6. Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2 (show MYL2 Proteins), was 100 times stronger than that of daunorubicin (DNR) and CM.

  7. hypertrophied myocytes after TAC have alpha-MyHC only. These data challenge the current paradigm of the fetal hypertrophic gene program and identify a new subpopulation of smaller working ventricular myocytes with more myosin.

  8. the alpha-isoform of myosin heavy chain is the pathogenic autoantigen for CD4 (show CD4 Proteins)+ T cells in myocarditis

  9. Silencing of aMHC is associated at its promoter with decreased H3K4me3, but not decreased H3ac.

  10. TCDD represses the expression of the cardiac development-specific Nkx2.5 homeobox transcription factor, of cardiac troponin-T and of alpha- and beta-myosin heavy chains.

Zebrafish Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) interaction partners

  1. Data show that an atrium-specific contractility defect due to mutation of the atrial myosin heavy chain has a profound impact on ventricular development.

Myosin Heavy Chain 6, Cardiac Muscle, alpha (MYH6) Protein Profile

Protein Summary

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.

Gene names and symbols associated with MYH6

  • myosin, heavy chain 1E, skeletal muscle (similar to human myosin, heavy chain 1, skeletal muscle, adult) (MYH1E)
  • myosin, heavy chain 6, cardiac muscle, alpha (MYH6)
  • myosin, heavy chain 6, cardiac muscle, alpha (Myh6)
  • myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6)
  • myosin, heavy polypeptide 6, cardiac muscle, alpha (myh6)
  • A830009F23Rik protein
  • AA517445 protein
  • adult protein
  • alpha-MHC protein
  • amhc protein
  • ASD3 protein
  • CMD1EE protein
  • CMH14 protein
  • MYH1 protein
  • MYH6 protein
  • MYHC protein
  • Myhc-a protein
  • MyHC-alpha protein
  • Myhca protein
  • myosin protein
  • Myosin-6 protein
  • SSS3 protein

Protein level used designations for MYH6

alpha (cardiomyopathy , cardiac muscle , heavy chain 1 , heavy chain 6 , heavy polypeptide 1 , hypertrophic 1) , myosin heavy chain, skeletal muscle, adult , myosin, heavy chain 1, skeletal muscle, adult , myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) , myosin, heavy polypeptide 1, skeletal muscle, adult , skeletal muscle , myHC-alpha , myosin heavy chain 6 , myosin heavy chain, cardiac muscle alpha isoform , myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) , myosin-6 , myosin heavy chain polypeptide 6 cardiac muscle adult , myosin heavy chain, polypeptide 6, cardiac muscle, alpha , myosin, heavy polypeptide 6, cardiac muscle, alpha , Myosin heavy chain 6 , alpha-cardiac myosin heavy chain , Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha) , alpha cardiac MHC , alpha myosin , cardiac myosin heavy chain alpha isoform , cardiomyopathy, hypertrophic 1 , myosin heavy chain, cardiac muscle, adult , atrial myosin heavy chain , myosin-7 , wea , weak atrium

GENE ID SPECIES
427788 Gallus gallus
100296004 Bos taurus
4624 Homo sapiens
100685644 Canis lupus familiaris
100125987 Oryctolagus cuniculus
29556 Rattus norvegicus
100727418 Cavia porcellus
101120580 Ovis aries
101825281 Mesocricetus auratus
17888 Mus musculus
386711 Danio rerio
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