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The protein encoded by MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping Myostatin Kits (79) and Myostatin Proteins (70) and many more products for this protein.
Showing 10 out of 232 products:
Human Polyclonal MSTN Primary Antibody for EIA - ABIN115510
Wolfman, McPherron, Pappano, Davies, Song, Tomkinson, Wright, Zhao, Sebald, Greenspan, Lee: Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases. in Proceedings of the National Academy of Sciences of the United States of America 2003
Show all 4 references for ABIN115510
Human Polyclonal MSTN Primary Antibody for WB - ABIN108525
McPherron AC,Lee SJ: Double muscling in cattle due to mutations in the myostatin gene. in Proc Natl Acad Sci U S A 1997
Show all 3 references for ABIN108525
Human Polyclonal MSTN Primary Antibody for EIA, IHC (p) - ABIN357462
Hamrick, McPherron, Lovejoy: Bone mineral content and density in the humerus of adult myostatin-deficient mice. in Calcified tissue international 2002
Show all 3 references for ABIN357462
Human Monoclonal MSTN Primary Antibody for ELISA, WB - ABIN969306
Awano, Takeshima, Okizuka, Saiki, Yagi, Matsuo: Wide ranges of serum myostatin concentrations in Duchenne muscular dystrophy patients. in Clinica chimica acta; international journal of clinical chemistry 2008
Show all 2 references for ABIN969306
Human Monoclonal MSTN Primary Antibody for WB - ABIN1108369
Wójcik, Nogalska, Engel, Askanas: Myostatin and its precursor protein are increased in the skeletal muscle of patients with Type-II muscle fibre atrophy. in Folia morphologica 2008
improving muscle growth in a fish species by mixing a classical strategy, such as compensatory growth, and a biotechnological approach, such as the use of recombinant proteins for inhibiting the biological actions of MSTN(Myostatin)
the expression of myostatin during development and the effects of its knock-down on various genes such as muscle regulatory transcription factors (MRFs), muscle-specific (show EIF3K Antibodies) proteins (MSP (show MST1 Antibodies)), and insulin (show INS Antibodies)-like growth factors (IGFs).
Epistatic analyses suggest a possible genetic interaction between Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis
TALENs-mediated gene disruption of myostatin produces a larger phenotype of medaka with an apparently compromised immune system
Findings suggest that myostatin (MSTN) function is required for regulating the appropriate growth of skeletal muscle in medaka
our data showed a virtual absence of the variant (K) allele in MSTN rs1805086 in Japanese population, and no differences in allele/genotype frequencies in ACTN3 (show ACTN3 Antibodies) rs1815739 among centenarians and healthy controls of this country.
MSTN, but not GDF11 (show GDF11 Antibodies), declines in healthy men throughout aging.
Multivariate regression analysis revealed that myostatin levels correlated significantly with tricuspid annular plane systolic excursion values and right ventricle myocardial performance index among the study patients
Study measured circulating myostatin levels in seven inherited muscle diseases using an immunoaffinity LC-MS/MS approach, found significantly lower serum myostatin concentrations in numerous muscle disease patient populations and the associations with clinical measurements suggests the potential utility of myostatin as a biomarker of genetic muscle disease progression
data indicated that serum myostatin concentration did not correlate with muscle and bone mass in postmenopausal women
Myostatin mRNA expression in skeletal muscle was significantly reduced compared with pre-exercise values at all time points with no difference between exercise intensity.
Low expression of serum MSTN is associated with Cachexia Prevention in Patients with Medullary Thyroid Cancer.
Myostatin was differentially expressed in the muscle and adipose tissue in relation to physical activity and dysglycaemia
Our results suggest that serum levels of myostatin and irisin (show FNDC5 Antibodies) are related in patients with type 2 diabetes
Matrix metalloproteinase 14 (show MMP14 Antibodies) was highly expressed in uterine leiomyoma and correlated with myostatin and activin A (show INHBA Antibodies) mRNA expression. Moreover, MMP14 (show MMP14 Antibodies) and myostatin mRNA expression correlated significantly and directly with the intensity of dysmenorrhea.
GDF8 plays a significant regulatory role in bone formation and bone resorption
Genetic inactivation of myostatin increases maximal force and power, but in return it reduces muscle quality, particularly in male mice.
findings indicate that myostatin directly influences osteocyte function and thereby inhibits osteoblastic differentiation, at least in part, through the suppression of osteocyte-derived exosomal miR (show MLXIP Antibodies)-218, suggesting a novel mechanism in muscle-bone communication.
The 12-bp Mstn(Cmpt-dl1Abc) deletion decreases adiposity and improves whole body glucose uptake, insulin (show INS Antibodies) sensitivity, and (18)FDG (show SMUG1 Antibodies) uptake of skeletal muscle and white adipose tissue.
In this model, increased LTBP4 (show LTBP4 Antibodies) led to greater muscle mass with proportionally increased strength, and decreased fibrosis. The increase in muscle mass and reduction in fibrosis were similar to what occurs when myostatin, a related TGFbeta (show TGFB1 Antibodies) family member and negative regulator of muscle mass, was deleted in mdx (show DMD Antibodies) mice
myostatin dysfunction impairs adaptation of the soleus muscle to high functional demands.
Evidences indicate that the suppression of MSTN cause to increase the regenerative potential of injured soleus muscle via the increase in the population of muscle satellite cells regardless of unloading conditions.
A role for Nfix (show MLZE Antibodies) in postnatal skeletal muscle development and regeneration and Myostatin gene expression regulation.
Myostatin deletion specifically affects skeletal muscle mitochondrial function and redox status. Decreased mitochondrial function and oxidative markers persisted in aged mstn KO mice. However, muscle hypertrophy and the redox status related to this genotype appeared as beneficial side effects attenuating the age effect, as metabolic changes become less pronounced in comparison with WT mice.
A synthetic peptide corresponding to this decorin (show DCN Antibodies) region dose-dependently inhibited the response to myostatin in cardiomyocytes
These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (show FOXO3 Antibodies) and glucocorticoid receptor (show NR3C1 Antibodies) binding to its promoter.
Loss of MSTN increases muscle mass in pigs, which may help increase pork production for consumption in the future.
Data show that the protein level of The protein level of myostatin (MSTN) was decreased in the mutant cloned pigs compared with the wild-type controls.
Single nucleotide polymorphisms in the MYOD1 (show MYOD1 Antibodies) and GDF8 genes are associated with genetic transcription during myogenesis in pigs.
The level of myostatin inversely correlated with miR (show MYLIP Antibodies)-27a in fat and heart of pigs and also in proliferating porcine myoblasts. Overexpression of miR (show MYLIP Antibodies)-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin.
MSTN g.435G>A and g.447A>G affected carcass traits in pigs
The genotypes of MSTN g.435G > A and g.447A > G SNPs in Duroc pigs were studied. The 435GG/447AA (show COL16A1 Antibodies) individually had significantly higher average daily gain, body weight at 70 d and 150 d , and a lower age at 110 kg than 435AA/447GG individuals.
Porcine MSTN could be upregulated by isobutyl-1-methylxanthine , MyoD (show MYOD1 Antibodies), and PPARgamma (show PPARG Antibodies) but downregulated by C/EBPalpha (show CEBPA Antibodies) and C/EBPbeta (show CEBPB Antibodies).
a vital enhancer region was identified between nucleotides -218 and -137 in promoter region of porcine myostatin
It was concluded that myostatin is a factor broadly expressed in the internal organs and muscle tissues of pigs.
Data indicate that the the promoter trap vector PIII-myostatin could knock out the bovine myostatin gene.
The effects of myostatin and myogenic factor 5 (show MYF5 Antibodies) polymorphisms on growth and muscle traits of Marchigiana breed were assessed.
we demonstrate zygote injection of TALEN mRNA can also produce gene-edited cattle and sheep. In both species we have targeted the myostatin (MSTN) gene.
proof-of-concept study is the first to produce MSTN mutations in cattle, and may allow the development of genetically modified strains of double-muscled cattle.
Mutations in the leader peptide of the bovine myostatin gene effectively promote the proliferation of bovine fibroblast cells.
there were 18 SNPs identified in the Qinchuan cattle promoter region compared with those of other cattle compared to the Red Angus cattle myostatin promoter region.
A 3-way interaction of myostatin genotype (MG), season, and trigonometric function periodicities of 24 h and 12 h indicate that a genotype x environment interaction exists for MG.
These results show for the first time that myostatin regulates the differential expression of chemokines in skeletal muscle cells.
bovine myostatin is a specific target of miR (show MYLIP Antibodies)-27b and that miRNAs contribute to explain additive phenotypic hypertrophy in Piedmontese cattle selected for the MSTN gene mutation
Mutations in the myostatin gene, responsible for the double muscling condition in cattle, were targeted to estimate the time since the most recent common ancestor. Each myostatin allele had a recent common ancestor (<400 years ago).
The reduced expression of myostatin gene was achieved and measured in clonal fibroblast cells by real-time PCR.
This study also suggests the importance of siRNA-mediated knockdown of MSTN as a potential alternative to increase muscle mass and meat production.
A study of the MSTN 5' upstream region and investigation of 5'UTR (show UTS2R Antibodies) TTTTA deletion was carried out in seven different Indian goat breeds. An 1181 bp fragment of 5' upstream region of MSTN gene was PCR amplified, cloned, and sequenced.
myostatin plays a negative role in regulating the expression of adipogenesis related genes in goat fetal fibroblasts.
Polymorphisms of myostatin gene as markers associated with growth in Boer goats.
The effect of an Equine Repetitive Element 1 insertion in the promoter of the myostatin gene, which is involved in muscle development, was also investigated.
Myostatin mRNA but not protein was increased in skeletal muscle of obese compared with lean animals. Myostatin mRNA was increased in crest fat of obese animals and protein was undetectable. Serum myostatin was higher in obese than lean animals.
The tissue-specific presence of myostatin, the moystatin receptor (activin receptor IIB (show ACVR2B Antibodies), ActRIIB (show ACVR2B Antibodies)), follistatin (show FST Antibodies) and perilipin (show PLIN1 Antibodies), genes and proteins across a range of equine tissues, were examined.
The candidate for racing performance genomic region contained eight genes annotated by ENSEMBL, including the myostatin gene (MSTN).
Polymorphisms of the MSTN promoter region in 5 horse breeds in Poland are reported.
significant association observed between genotype and mRNA abundance for untrained horses with the C/C cohort having highest MSTN mRNA levels,T/T group lowest levels and C/T group intermediate levels; following training there was significant decrease in MSTN mRNA which was most apparent for the C/C cohort
Exon 2 of the MSTN gene, which encodes part of the TGF-beta (show TGFB1 Antibodies) pro-peptide, was sequenced in 332 horses of 20 different breeds and compared with the horse MSTN gene sequence deposited in GenBank. The sequences obtained revealed the presence of 11 haplotypes represented by 10 variable nucleotide mutations, eight of them corresponding to amino acid sequence changes.
Variation at the MSTN gene influences speed in Thoroughbred horses.
This study demonstrates that the g.66493737C>T single nucleotide polymorphism in MSTN provides the most powerful genetic marker for prediction of race distance aptitude in Thoroughbreds.
Characterized the horse (Equus caballus) MSTN gene and identified and analysed single nucleotide polymorphisms (SNPs) in breeds of different morphological types.
Alignment of sequence data with the GenBank sequence of the rabbit MSTN gene identified three single nucleotide polymorphisms (SNPs). Significant linkage was found between the novel SNP c.373+234G>A and nine carcass composition traits.
These results suggest that the mutations in the upstream regulatory region of the MSTN gene are beneficial to the rabbit soma development, and the mutations can be used as molecular markers for the selection of the meat quality of rabbits.
Studied and compared mRNA levels of myostatin (MSTN), myogenin (MyoG (show MYOG Antibodies)), and myosin heavy chain (MyHC (show MYH13 Antibodies)) in skeletal muscles of two rabbit breeds with different body sizes and growth rates.
indicated that MSTN is not an important source of variability for performance traits, at least in the rabbit population
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
Growth/differentiation factor 8
, growth/differentiation factor-8
, growth differentiation factor 8
, growth/differentiation factor 8