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Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Additionally we are shipping N-Acetyltransferase 15 Antibodies (33) and N-Acetyltransferase 15 Kits (4) and many more products for this protein.
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analysis of the mode of cytosolic Naa60 anchoring to the Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-translational N-terminal acetylation of many transmembrane proteins
Knockdown of the N-terminal acetyltransferase (show NAA15 Proteins) Naa60 compromises Golgi ribbon integrity.
The first crystal structure of the N-terminal acetyltransferase (show NAA15 Proteins) Naa60 reveals two elongated loops important for substrate-specific binding not found in other NAT (show BRD2 Proteins) structures.
Naa60 is necessary for maintenance of the Golgi ribbon through its Nt-acetylation of substrate protein(s) that is/are involved in Golgi ribbon structural and/or functional organization.
Naa60 is an N-terminal acetyltransferase (show NAA15 Proteins) defined as NatF. Human and Drosophila melanogaster Naa60 acetylate Met-Lys (show LYZ Proteins)- and other Met-starting N-termini. In Drosophila cells, NAA60 knockdown induced chromosomal segregation defects.
HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms [HAT4]
Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase (By similarity).
N-acetyltransferase 15 (GCN5-related, putative)
, N-acetyltransferase UNQ2771/PRO7155 homolog
, N-alpha-acetyltransferase 60
, natF catalytic subunit
, histone acetyltransferase type B protein 4
, GNAT acetyltransferase
, GNAT acetytransferase