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The protein encoded by NEK6 is a kinase required for progression through the metaphase portion of mitosis. Additionally we are shipping NEK6 Proteins (13) and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal NEK6 Primary Antibody for WB - ABIN1882104
Belham, Roig, Caldwell, Aoyama, Kemp, Comb, Avruch: A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. in The Journal of biological chemistry 2003
Show all 4 references for ABIN1882104
Chicken Polyclonal NEK6 Primary Antibody for WB - ABIN2773927
Lee, Hyun, Chun, Kang: Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. in Biochemical and biophysical research communications 2007
NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
NEK6 (show NEK5 Antibodies) forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
overexpression of PAK1 (show PAK1 Antibodies), NEK6, AURKA (show AURKA Antibodies), and AURKB (show AURKB Antibodies) genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population.
We found that NEK6-mediated phosphorylation of TPP1 (show TPP1 Antibodies) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (show TPP1 Antibodies). Furthermore, we found evidence that POT1 (show POT1 Antibodies) negatively regulates TPP1 (show TPP1 Antibodies) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 (show POT1 Antibodies) mutant lacking its OB-fold domains
Overexpression of AURKA (show AURKA Antibodies) and NEK6 genes was significantly more pronounced in Ulcerative colitis patients with more extensive colon involvement
NEK6 suppresses the cell growth arrest induced by TGFbeta (show TGFB1 Antibodies). Mechanically, NEK6 blocks nuclear translocation of Smad4 (show SMAD4 Antibodies), which is essential for TGFbeta (show TGFB1 Antibodies) function.
Nek6 is also a critical signaling molecule that helps prevent cardiac hypertrophy and inhibits the Akt (show AKT1 Antibodies) signaling pathway.
Nek6 facilitates association of Hsp72 (show HSPA1A Antibodies) with the mitotic spindle, where it promotes stable K-fiber assembly through recruitment of the ch-TOG (show CKAP5 Antibodies)-TACC3 (show TACC3 Antibodies) complex.
Nek6 plays an important role in the premature senescence of cancer cells.
High Nek6 is associated with hepatic cell cancer.
Nek9 (show NEK9 Antibodies) is a Plk1 (show PLK1 Antibodies)-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 (show KIF11 Antibodies).
These results suggest that the increased expression of Nek6 renders cancer cells resistant to premature senescence, and targeting Nek6 could be an efficient strategy for cancer treatment.
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene.
NIMA-related expressed kinase 6
, never in mitosis A-related kinase 6
, nimA-related protein kinase 6
, serine/threonine-protein kinase Nek6
, putative serine-threonine protein kinase
, NIMA (never in mitosis gene a)-related kinase 6
, protein kinase SID6-1512
, NIMA (never in mitosis gene a)-related expressed kinase 6