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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Additionally we are shipping Neurofilament, Heavy Polypeptide Antibodies (449) and Neurofilament, Heavy Polypeptide Proteins (8) and many more products for this protein.
Showing 10 out of 39 products:
Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200, and calbindin (show CALB1 ELISA Kits) in mouse motor neurons.
Data conclude that NF-H and NF-M (show CEBPB ELISA Kits) C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons.
plasma NfH levels closely reflect later stages of disease progression and therapeutic response in the SOD1 (show SOD1 ELISA Kits)(G93A) mouse model of amyotrophic lateral sclerosis
NFH expression reveals an exquisite level of Cb stripe complexity that respects the transverse zone divisions and delineates an intricately patterned target field for Cb afferents.
results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H and NF-M (show CEBPB ELISA Kits)
Overexpression of peripherin (show PRPH ELISA Kits) in mice deficient for neurofilament light (NF-L (show NEFL ELISA Kits)) subunits induced a progressive ALS-like spinal motor neuron degeneration (show CLN8 ELISA Kits) prevented by simultaneous overexpression of NF-H
NF-H regulates the association of NFs with kinesin. Phosphorylation of NF-H dissociates NFs from kinesin and provides a mechanism by which NF-H phosphorylation can contribute to the slowing of NF axonal transport.
Alpha-internexin (show INA ELISA Kits) coassembles with all 3 neurofilament proteins into a single network of filaments in quadruple-transfected cells. Deleting NF-M (show CEBPB ELISA Kits) alone or together with NF-H in mice reduces alpha-internexin (show INA ELISA Kits) transport & content in axons throughout the CNS.
We have validated the serum pNF-H assay as an unbiased measurement of axonal injury in EAE, facilitating rapid screening of potential neuroprotective therapies in this model.
RE1 silencing transcription factor (show REST ELISA Kits) (REST) plays a contributory role in the neuron-specific expression of the alpha-internexin (show INA ELISA Kits), NF-H and NF-M (show CEBPB ELISA Kits) genes
This study confirmed the general applicability of the monocentric obtained cut-off values for neurofilamens in ALS, especially for pNfH
data support the use of Cebrospinal fluid phosphorylated NFH as a prognostic biomarker for amyotrophic lateral sclerosis.
Study found a significant correlation between values of 8-hydroxy-2'-deoxyguanosine and phosphorylated NF-H only in clinically isolated syndrome group. While the plasma values of 8-hydroxy-2'-deoxyguanosine reflect the degree of acute demyelination in clinically isolated syndrome, phosphorylated NF-H values reflect that in relapsing-remitting multiple sclerosis.
Results provide evidence that in particular pNfH can be used as a good diagnostic biomarker of ALS (show IGFALS ELISA Kits) at the diagnostic stage. Moreover, results indicate that NfL (show NEFL ELISA Kits) may be useful in monitoring disease progression in a subset of patients.
Level of neurofilament heavy chain and light chains were significantly elevated in the cerebrospinal fluid of Amyotrophic Lateral Sclerosis (ALS) patients compared to healthy controls/controls without parenchymal central nervous system involvement and ALS mimic disease patients.
Study found a significant increase of pNF-H levels in both plasma and CSF (show CSF2 ELISA Kits) in amyotrophic lateral sclerosis patients
Studied diagnostic Value of Serum Levels of GFAP (show GFAP ELISA Kits), pNF-H, and NSE (show ENO2 ELISA Kits) Compared With Clinical Findings in Severity Assessment of Human Traumatic Spinal Cord Injury.
This study demonstrated that Higher NF-L (show NEFL ELISA Kits) concentrations (beta = -0.26) were associated with functional decline in patients with vascular burden.
Phospho-NFH levels were significantly higher in amyotrophic lateral sclerosis patients in comparison with controls, in particular in fast progressors.
Data identified NEFH methylation as a candidate epigenetic marker for prognosis of RCC patients as well as prediction of anti-vascular endothelial growth factor-based therapy response.
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
neurofilament heavy polypeptide
, 200 kDa neurofilament protein
, neurofilament 200kDa
, neurofilament triplet H protein
, neurofilament, heavy polypeptide 200kDa
, neurofilament, heavy polypeptide
, neurofilament, heavy polypeptide 200kDa-like
, heavy neurofilament protein
, intermediate filament protein