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NEUROG2 encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. Additionally we are shipping Neurogenin 2 Antibodies (73) and many more products for this protein.
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histone H3K9 demethylation has a critical role during Neurog2-mediated neuronal transcription
Phosphorylation of Ngn2 occurs in both the N- and C-terminal regions, either side of the conserved basic Helix-Loop-Helix domain.
NeuroD (show NEUROD1 Proteins) promoter is substantially more sensitive to the phosphorylation status of Ngn2 than the Delta promoter, and that this can be attributed to differences in the ease of promoter activation.
multi-site cdk (show CDK4 Proteins)-dependent phosphorylation of Ngn2 interprets cdk (show CDK4 Proteins) levels to control neuronal differentiation in response to cell cycle lengthening during development
XNgnr1 positively regulates early neural cell death
Data demonstrate that Neurogenin and NeuroD preferentially recognize neurogenesis-related targets through an enhancer signature of clustered consensus-binding sites and regulate neurogenesis by activating a core set of transcription factors.
Study shows neurogenin 2 enhances the generation of patient-specific induced neuronal cells.
Results show that neurogenin-1 (show NEUROG1 Proteins) and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media.
human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury
Novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.
expression of Ngn2 during the differentiation of neuronl human embryo stem cells.
Rat and mouse species-dependent differences of Nurr1 (show NR4A2 Proteins) and Ngn2 actions in dopamine neuron differentiation.
data suggest that common reprogramming mechanisms exist driving the conversion of lineage-distant somatic cell types to neurons and reveal a critical role for CEND1 (show CEND1 Proteins) in NEUROG2-driven astrocytic reprogramming.
Findings suggest the strict spatio-temporal expression of Notch (show NOTCH1 Proteins) effector genes plays an important role during hippocampal neurogenesis and suggests that Notch1 (show NOTCH1 Proteins), Hes1 and Ngn2 were regulated by changing some specific CpG sites of their promoters.
IFN-gamma (show IFNG Proteins) inhibits neuronal differentiation of neural progenitor cells by negatively regulating the expression of Neurog2 via the JAK (show JAK3 Proteins)/STAT1 (show STAT1 Proteins) pathway.
In mid-embryonic neocortical walls, expression of Neurog2-d4Venus mostly overlapped with that of Neurog2 protein, with a slightly (1 h) delayed onset.
APP (show APP Proteins)-stimulated neuronal differentiation of NSPCs is mediated by Ngn2
Notch (show NOTCH1 Proteins) signaling controls the overall tempo of retinogenesis through Atoh7 (show ATOH7 Proteins) and Neurog2, by integrating cell fate specification, the wave of neurogenesis and the developmental status of cells ahead of this wave
Neurog1 (show NEUROG1 Proteins) and Neurog2 have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of neurons
Neurog2 functions as a transcriptional activator to initiate the expression of several genetic off-switches, each of which repress distinct gene expression programs during neocortical development.
Sustained vs. oscillating expressions of Ngn2, Dll1 and Hes1: a model of neural differentiation of embryonic telencephalon.
Neurog1 (show NEUROG1 Proteins)/2 together coordinate development of the olfactory system, which depends on tissue interactions between the olfactory bulb and epithelium.
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons.
class A basic helix-loop-helix protein 8
, protein atonal homolog 4
, atonal homolog 4
, helix-loop-helix protein mATH-4A
, atonal-like protein 4a
, neurogenin 2
, neurogenin-related 1a
, neurogenin-related 1b