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Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. Additionally we are shipping Neurogranin Kits (11) and Neurogranin Proteins (9) and many more products for this protein.
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The results of this study indicated that elevated neurogranin function within the PFC (show CFP Antibodies) can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks.
Neurogranin knockout mice are hyperactive and socially withdrawn.
findings suggest that mobilization of CaM (show Calm2 Antibodies) and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2 (show CA2 Antibodies)+ transients and activation of Ca2 (show CA2 Antibodies)+/CaM (show Calm2 Antibodies)-dependent enzymes.
We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 (show CAMK2N1 Antibodies) loci will increase the diversity of posttranscriptional regulation
Results provide a new specific neurochemical marker to identify a subpopulation of olfactory granule cells and suggest possible functional implications for neurogranin in olfactory bulb plasticity mechanisms.
Attenuation of protein kinase C (show PKC Antibodies) and cAMP-dependent protein kinase (show CDK7 Antibodies) signal transduction in the neurogranin knockout mouse
Neurogranin expression in the cerebellum by brush cells, which are excitatory, shows remarkable cell type- and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms.
calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3
NMDA induced a rapid and transient phosphorylation and oxidation of neurogranin in mouse hippocampal slices
NG is expressed by principal cells in different neocortical layers and in the hippocampus by granule cells of the dentate gyrus and pyramidal neurons of CA1 (show CA1 Antibodies)-CA3 (show CA3 Antibodies).
Neurogranin and YKL-40 (show CHI3L1 Antibodies) are promising AD biomarkers, independent of and complementary to the established core Alzheimer's disease (AD) biomarkers, reflecting additional pathological changes in the course of AD
These results confirm an increase in CSF (show CSF2 Antibodies) Ng concentration in patients with AD as previously reported and show that this is specific to AD and not seen in a range of other neurodegenerative diseases.
This report provides evidence to support larger and controlled traumatic brain injury clinical studies for NRGN validation and prediction of outcomes.
Within-person levels of NGRN (show NGRN Antibodies) increased in cognitively normal participants but not in patients with later stage mild cognitive impairment or Alzhiemer's disease; NGRN (show NGRN Antibodies) may reflect presymptomatic synaptic dysfunction or loss.
Cerebrospinal fluid neurogranin was increased in patients with Alzheimer's dementia, progressive mild cognitive impairment (MCI (show MCIN Antibodies)) and stable MCI (show MCIN Antibodies) compared with controls, and in Alzheimer's dementia and progressive MCI (show MCIN Antibodies) compared with stable MCI (show MCIN Antibodies).
neurogranin binds to alpha-synuclein (show SNCA Antibodies) in the human cortex, and this interaction decreases in Parkinson's disease along with the phosphorylation of neurogranin, a molecular process thought to be involved in learning and memory
These findings help to clarify underlying NRGN mediated pathophysiological mechanisms involving cortical-subcortical brain networks in schizophrenia.
Data indicate that neurogranin makes contacts with both the N- and C-domains of calmodulin (show CALM1 Antibodies) that functionally leads to altered calcium binding kinetics.
NRGN risk variants contribute to subtle changes in neural functioning and anatomy.
Our results support an association between the NRGN gene and schizophrenia and a hypothesis that the NRGN gene may mediate the risk associated with schizophrenia via intellectual dysfunction.
interaction of Ca(2 (show CA2 Antibodies)+)-free calmodulin (show KRIT1 Antibodies) (apoCaM) with the IQ motif corresponding to the calmodulin (show KRIT1 Antibodies)-binding domain of neurogranin has been studied by nuclear magnetic resonance (NMR) methods
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
neurogranin (protein kinase C substrate, RC3)
, postsynaptic spine 1
, protein kinase C substrate
, protein kinase C substrate 7.5 kDa protein
, calmodulin-binding protein
, B-50 immunoreactive C-kinase substrate
, protein kinase C substrate, RC3